Antimicrobial Resistance

Objective. To determine the structure of antimicrobial resistance of clinical isolates of pneumococci in different regions of Russia. Materials and Methods. A total of 210 Streptococcus pneumoniae strains isolated in 15 centres of Central (Moscow – 5 centers, Kazan, Nizniy Novgorod, Ryzan), North-Western (Smolensk, Saint-Petersburg), Southern (Krasnodar) regions, Urals (Ekaterinburg) and Siberia (Novosibirsk, Tomsk) were included in this study. Susceptibility to 19 antimicrobials – penicillin G, amoxicillin, amoxicillin/clavulanate, cefotaxime, cefepime, erythromycin, azithromycin, clarithromycin, midecamycin, midecamycin acetate, spiramycin, clindamycin, tetracycline, ciprofloxacin, levolfloxacin, chloramphenicol, co-trimoxazole, rifampicin and vancomycin – was determined by broth microdilution in accordance with NCCLS recommendations.

Objective. To determine in vitro activity of fusidic acid and other antimicrobials available for topical use against S. aureus isolated from hospitalised patients. Materials and Methods. A total of 879 clinical strains of S. aureus isolated in 2000-2001 from patients hospitalised in 17 medical institutions in different parts of Russia - 4 in Central region, 2 in North-West region, 3 in South region, 2 in Volga region, 3 in Ural region, 3 in Siberian region, were included in the study.

The rates of nasopharyngeal carriage of Haemophilus influenzae and epidemiology of its antimicrobial resistance in healthy children from day-care centers have been investigated. The overall rate of nasopharyngeal H.influenzae carriage was 44%. The …

β-Lactamases are represented by extensive range of genetically and functionally different enzymes that are able to destroy β-lactams that leads to development of resistance to these antibiotics in β-lactamases producing bacteria. Intrinsic production …

Translated and reprinted with permission from «Emerging Infectious Diseases» 2000; 6:552-6.

Resistance of Streptococcus pneumoniae to antimicrobial drug is increasing. To investigate the relationship between antimicrobial use and …

The mechanisms of resistance to aminoglycoside antibiotics in Gram-negative nosocomial pathogens isolated in four Russian hospitals were studied. The most common and almost exclusive mechanism of aminoglycoside resistance was production of …

The treatment options for the therapy of anaerobic infections, the most typical anaerobic pathogens and their mechanisms of resistance to antimicrobials are given in the article. The data on the susceptibility testing of Bacteroides spp., Clostridium …

Sensitivity of 100 enterococcal strains isolated from faeces in premature born unit to 15 antimicrobial agents has been studied. 33 strains of Enterococcus faecalis, 61 strains of Enterococcus faecium, 4 strains of Enterococcus casseliflavus and 2 …

The purpose of the study – to determine antimicrobial susceptibility of Shigella spp. and Salmonella spp. isolated in Ekaterinburg during June–September 1999. Susceptibility to ampicillin, ampicillin/sulbactam, ciprofloxacin, norfloxacin, …

The purpose of the study – to determine the antimicrobial resistance of Shigella sonnei and Shigella flexneri isolated in Smolensk Region and to develop recommendations for empiric therapy of shigellosis. A total of 88 strains of S.flexneri and 69 …