Antimicrobial Resistance

Objective. Objectives. To study incidence and changes of fluoroquinolone resistance among Mycobacterium tuberculosis in Novosibirsk region, and to determine fluoroquinolone contribution to drug resistance selection in M. tuberculosis population. Materials and Methods. A total of 344 clinical isolates of M. tuberculosis obtained from patients with newly diagnosed tuberculosis during the periods of 2000–2002 and 2006–2010 were tested for susceptibility to fluoroquinolones. This study included 141 isolates susceptible to first-line drugs and 83 isolates resistant to isoniazid and rifampicin (multi-drug resistance [MDR]), and 120 isolates resistant to one or more anti-TB drugs, but without MDR.

Objective. Objectives. To evaluate the level, structure and phenotypes of antimicrobial resistance in clinical respiratory strains of Streptococcus pyogenes in different regions of Russia during 1999–2009. Materials and Methods. In total 804 respiratory strains of S. pyogenes from different regions of Russia were included in the study. Susceptibility to 18 antimicrobials was evaluated by the standard broth microdilution method according to EUCAST 2012 recommendations. Results. β-Lactams remaine highly active against all tested strains.

At the present article we evaluate a relatively new method of the evaluation of activity of antimicrobials against bacterial biofilms. This method combines the possibilities of simultaneous evaluation of bacterial survival in biofilm in the presence …

Objective. Objectives. To investigate etiology and susceptibility of pathogens causing community-acquired urinary tract infections (UTIs) in different regions of Russia in various patients’ subsets to the most clinically used antimicrobials. Materials and Methods. A total of 903 uropathogens isolated from urine samples of children and adults of all age groups with acute (and recurrence of chronic) community-acquired UTIs, including pregnant women with asymptomatic bacteriuria were collected in 26 centers of 18 cities in Russia during 2010–2011 and included in the «DARMIS» study.

Currently, there is an ever-increasing consumption of probiotics contained in foods, food supplements, and medicinal products. A number of studies to determine efficacy of those products in different medical conditions is also increasing. Meanwhile, …

Here we report on a high incidence of quinolone resistance (43,1%) among nosocomial CTX-M-5 ESBLproducing S. Typhimurium isolates belonging to a single clonal group isolated in Russia, Belarus, and Kazakhstan. The resistance mechanism in all cases …

The prevalence and molecular epidemiology of MBLproducing Gram-negative bacteria have been studied in Russia (1998–2010), Belarus and Kazakhstan (2005– 2010). Analysis of nosocomial strains isolated as part of several multicentre surveillance studies …

Different mechanisms of antimicrobial resistance development in biofilm bacteria are reviewed in the article. Practical approaches to the susceptibility testing of bacteria in biofilms are analyzed.

In this paper, the evidence of broad geographic dissemination of Salmonella enterica serovar Typhimurium strains belonging to a single genetic lineage is presented. The isolates described possess resistance to oxiiminocephalosporines due to …

Methicillin-resistant Staphylococcus aureus (MRSA) ST239 is one of the most common nosocomial genotypes worldwide. Typical MRSA ST239 strains do not produce toxic shock syndrome toxin-1 (TSST-1), which is encoded by tst gene at staphylococcal …