Abstract
In total 284 clinical nosocomial S. aureus strains isolated in 2011–2012 from patients hospitalized in 25 hospitals in 18 Russian cities were included in the study. Susceptibility to 19 antimicrobials was assessed by serial dilution method in accordance with EUCAST recommendations (ver. 4.0 2014). Methicillin-resistance rate was 66.9%. Antimicrobials with the highest activity with no resistance detected were vancomycin and linezolid. Other highly in-vitro active antimicrobials were daptomycin (99.6%), fusidic acid (99.6%), mupirocin (99.6%), co-tromoxazole (97.2%), and tigecycline (95%). MRSA were substantially less susceptible compare with MSSA to gentamicin (24.7% vs 94.7%), clindamycin (53.7 vs 96.8%), rifampicin (78.9% vs 97.9%), tetracycline (46.8% vs 91.5%), chloramphenicol (16.8% vs 85.1%), ceftaroline (57.9% vs 100%), ciprofloxacin (1.6% vs 89.4%), and erythromycin (42.6% vs 89.4%).
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