Психобиотики: новое направление в психофармакологии, или как бактерии влияют на наш мозг? | КМАХ

Психобиотики: новое направление в психофармакологии, или как бактерии влияют на наш мозг?

Клиническая микробиология и антимикробная химиотерапия. 2022; 24(2):108-133

​ Андреева И.В., Толпыго А.В., Андреев В.А., Азизов И.С., Гольман И.А., Осипова Н.Н., Привольнев В.В., Стецюк О.У., Соколовская В.В.
10.36488/cmac.2022.2.108-133
психобиотики пробиотики Lactobacillus Bifidobacterium психическое здоровье когнитивная функция депрессия тревожное расстройство стресс расстройства аутистического спектра COVID-19
Раздел
Болезни и возбудители
Тип
Обзор
Публикация
Клиническая микробиология и антимикробная химиотерапия. 2022; 24(2):108-133

Аннотация

Психобиотики – это особый класс пробиотиков, которые оказывают благоприятное влияние на психическое здоровье человека. В последнее десятилетие появились убедительные доказательства, свидетельствующие о том, что микробиом кишечника влияет на психическое здоровье, когнитивные способности (обучение и память) и поведенческие процессы через неврологические, метаболические, гормональные и иммунологические сигнальные пути. В данном обзоре приводятся имеющиеся сведения о механизмах регуляции микробиотой нейроиммунных осей, описываются схемы взаимодействия микробиоты с кишечной нервной системой и осью «мозг-кишечник», влияние на поведение, когнитивные функции и эмоции, а также обсуждаются доказательная база и современные взгляды на использование психобиотиков в качестве безопасной и эффективной терапевтической альтернативы классическим психотропным препаратам при депрессивных и тревожных расстройствах, стрессе, расстройствах аутистического спектра, болезни Альцгеймера и других состояниях.

Андреева Ирина Вениаминовна

НИИ антимикробной химиотерапии ФГБОУ ВО СГМУ Минздрава России, Смоленск, Россия

Толпыго А.В.

ФГБОУ ВО «Смоленский государственный медицинский университет» Минздрава России, Смоленск, Россия

Андреев В.А.

ФГБОУ ВО «Смоленский государственный медицинский университет» Минздрава России, Смоленск, Россия

Азизов Илья Сулейманович

НИИ антимикробной химиотерапии ФГБОУ ВО СГМУ Минздрава России, Смоленск, Россия

Гольман И.А.

АНО ВО «Московский гуманитарный университет», Москва, Россия

Осипова Н.Н.

ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России, Москва, Россия

Привольнев Владислав Владимирович

АО «Р-Фарм», Москва, Россия

Стецюк Ольга Ульяновна

НИИ антимикробной химиотерапии ФГБОУ ВО СГМУ Минздрава России, Смоленск, Россия

Соколовская В.В.

ФГБОУ ВО «Смоленский государственный медицинский университет» Минздрава России, Смоленск, Россия

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