Транслокация кишечной микрофлоры при циррозе печени: механизм, клиническое значение, маркеры

Иванович Гавриленко Дмитрий; Н.Н.  Силивончик

doi:10.36488/cmac.2021.2.147-160

Транслокация кишечной микрофлоры при циррозе печени: механизм, клиническое значение, маркеры

Клиническая микробиология и антимикробная химиотерапия. 2021; 23(2):147-160

Гавриленко Д.И., Силивончик Н.Н.

10.36488/cmac.2021.2.147-160

цирроз печени кишечная микрофлора бактериальная транслокация маркеры липополисахарид инфекция летальность

Раздел

Болезни и возбудители

Тип

Обзор

Публикация

Клиническая микробиология и антимикробная химиотерапия. 2021; 23(2):147-160

Аннотация Авторы Литература PDF Статистика Репринты

Аннотация

Бактериальная транслокация считается основным механизмом развития бактериальных инфекций и формирования провоспалительного статуса у пациентов с циррозом печени, в то же время четких критериев для оценки этого явления не существует. Данная статья представляет собой обзор современных публикаций, посвященных проблеме транслокации кишечной микрофлоры. В обзоре рассматриваются изменения кишечного микробиома, местного физиологического барьера, а также особенности врожденного и адаптивного иммунитета, которые обусловливают формирование и прогрессирование цирроза печени. Приведены результаты исследований потенциальных маркеров бактериальной транслокации (С-реактивный белок, прокальцитонин, липополисахарид, пресепсин и др.) у пациентов с циррозом печени и их использования для прогнозирования развития инфекции и летальности. Описаны современные методы, используемые для изучения кишечного микробиома, а также направления будущих исследований.

Дмитрий Иванович Гавриленко

dm.gavrilenko891@gmail.com

ГУ «Республиканский научно-практический центр радиационной медицины и экологии человека», Гомель, Республика Беларусь

Силивончик Н.Н.

ГУО «Белорусская медицинская академия последипломного образования», Минск, Республика Беларусь

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Транслокация кишечной микрофлоры при циррозе печени: механизм, клиническое значение, маркеры

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