Региональные особенности распространения Candida auris | КМАХ

Региональные особенности распространения Candida auris

Клиническая микробиология и антимикробная химиотерапия. 2021; 23(2):117-125

​ Баранцевич Н.Е., Леванова В.В., Баранцевич Е.П.
10.36488/cmac.2021.2.117-125
Candida auris клады страны COVID-19 частота летальность
Раздел
Болезни и возбудители
Тип
Обзор
Публикация
Клиническая микробиология и антимикробная химиотерапия. 2021; 23(2):117-125

Аннотация

В статье представлены географические и временные параметры распространения Candida auris – микромицета, идентифицированного как новый вид дрожжевых грибов в 2009 г. Приведены данные, свидетельствующие о растущей частоте обусловленных им инфекций и быстром распространении из регионов происхождения – Южно-Азиатского, Восточно-Азиатского, Южно-Африканского и Южно-Американского – по всем континентам, исключая Антарктиду, особенно активном после 2016 г. Так, в Великобритании выявлены изоляты, принадлежащие 3 различным кладам, в США присутствуют все 4 клада. В России распространение получил южноазиатский клад, его появление было ассоциировано с трудовой миграцией из Средней Азии. Подчеркнута необходимость проведения эпидемиологического надзора за С. auris для выявления источников и путей передачи инфекции, а также особенностей распространения отдельных кладов. Крайне важно использовать существующее окно возможностей для предотвращения дальнейшего распространения возбудителя, способного вызывать вспышки внутрибольничных инфекций, в том числе в отделениях реанимации и интенсивной терапии. Необходима срочная имплементация профилактических мер, что особенно актуально в период пандемии COVID-19, учитывая появление данного гриба в новых странах и клиниках, а также повышение частоты инфекций, обусловленных С. auris, в ряде стационаров, оказывающих помощь инфицированным SARS-CoV-2 пациентам.

Баранцевич Н.Е.

ФГБУ «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России, Санкт-Петербург, Россия

Леванова В.В.

ФГБУ «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России, Санкт-Петербург, Россия

Баранцевич Елена Петровна

ФГБУ «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России, Санкт-Петербург, Россия

  • 1. Satoh K., Makimura K., Hasumi Y., Nishiyama Y., Uchida K., Yamaguchi H. Candida auris sp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital. Microbiol Immunol. 2009;53(1):4144. DOI: 10.1111/j.1348-0421.2008.00083.x
  • 2. Sabino R., Veríssimo C., Pereira Á.A., Antunes F. Candida auris, an agent of hospital-associated outbreaks: which challenging issues do we need to have in mind? Microorganisms. 2020;8(2):181. DOI: 10.3390/microorganisms8020181
  • 3. Lockhart S.R., Etienne K.A., Vallabhaneni S., Farooqi J., Chowdhary A., Govender N.P., et al. Simultaneous emergence of multidrug-resistant Candida auris on 3 continents confirmed by whole-genome sequencing and epidemiological analyses. Clin Infect Dis. 2017;64(2):134140. DOI: 10.1093/cid/ciw691
  • 4. Chakrabarti A., Sood P. On the emergence, spread and resistance of Candida auris: host, pathogen and environmental tipping points. J Med Microbiol. 2021;70(3):001318. DOI: 10.1099/jmm.0.001318
  • 5. Barantsevich N.E., Vetokhina A.V., Ayushinova N.I., Orlova O.E., Barantsevich E.P. Candida auris bloodstream infections in Russia. Antibiotics (Basel). 2020;9(9):557. DOI: 10.3390/antibiotics9090557
  • 6. Pchelin I.M., Azarov D.V., Churina M.A., Ryabinin I.A., Vibornova I.V., Apalko S.V., et al. Whole genome sequence of first Candida auris strain, isolated in Russia. Med Mycol. 2020;58(3):414-416. DOI: 10.1093/mmy/myz078
  • 7. Barantsevich N.E., Orlova O.E., Shlyakhto E.V., Johnson E.M., Woodford N., Lass-Floerl C., et al. Emergence of Candida auris in Russia. J Hosp Infect. 2019;102(4):445448. DOI: 10.1016/j.jhin.2019.02.021
  • 8. Tsay S., Welsh R.M., Adams E.H., Chow N.A., Gade L., Berkow E.L., et al. Notes from the field: ongoing transmission of Candida auris in health care facilities – United States, June 2016 – May 2017. MMWR Morb Mortal Wkly Rep. 2017;66:514-515. DOI: 10.15585/mmwr.mm6619a7
  • 9. Moreno M.V., Simian M.E., Villarroel J., Fuenzalida L.M., Yarad M.F., Soto A., et al. Primer aislamiento de Candida auris en Chile [First isolation de Candida auris in Chile]. Rev Chilena Infectol. 2019;36(6):767-773. Spanish. DOI: 10.4067/S0716-10182019000600767
  • 10. Lane C.R., Seemann T., Worth L.J., Easton M., Pitchers W., Wong J. et al. Incursions of Candida auris into Australia, 2018. Emerg Infect Dis. 2020;26(6):1326-1328. DOI: 10.3201/eid2606.190936
  • 11. Chow N.A., de Groot T., Badali H., Abastabar M., Chiller T.M., Meis J.F. Potential fifth clade of Candida auris, Iran, 2018. Emerg Infect Dis. 2019;25(9):1780-1781. DOI: 10.3201/eid2509.190686
  • 12. Centers for Disease Control and Prevention. Tracking Candida auris. Available at: www.cdc.gov/fungal/candidaauris/tracking-c-auris.html. Accessed July 11, 2021.
  • 13. Adam R.D., Revathi G., Okinda N., Fontaine M., Shah J., Kagotho E., et al. Analysis of Candida auris fungemia at a single facility in Kenya. Int J Infect Dis. 2019;85:182-187. DOI: 10.1016/j.ijid.2019.06.001
  • 14. Al-Rashdi A., Al-Maani A., Al-Wahaibi A., Alqayoudhi A., Al-Jardani A., Al-Abri S. Characteristics, risk factors, and survival analysis of Candida auris cases: results of oneyear national surveillance data from Oman. J Fungi (Basel). 2021;7(1):31. DOI: 10.3390/jof7010031
  • 15. Kordalewska M., Zhao Y., Lockhart S.R., Chowdhary A., Berrio I., Perlin D.S. Rapid and accurate molecular identification of the emerging multidrug-resistant pathogen Candida auris. J Clin Microbiol. 2017;55(8):2445-2452. DOI: 10.1128/JCM.00630-17
  • 16. Lee W.G., Shin J.H., Uh Y., Kang M.G., Kim S.H., Park K.H., et al. First three reported cases of nosocomial fungemia caused by Candida auris. J Clin Microbiol. 2011;49(9):3139-3142. DOI: 10.1128/JCM.00319-11
  • 17. Kim M.N., Shin J.H., Sung H., Lee K., Kim E.C., Ryoo N., et al. Candida haemulonii and closely related species at 5 university hospitals in Korea: identification, antifungal susceptibility, and clinical features. Clin Infect Dis. 2009;48(6):57-61. DOI: 10.1086/597108
  • 18. Pfaller M.A., Diekema D.J., Turnidge J.D., Castanheira M., Jones R.N. Twenty years of the SENTRY Antifungal Surveillance Program: results for Candida species from 1997-2016. Open Forum Infect Dis. 2019;6(1):79-94. DOI: 10.1093/ofid/ofy358
  • 19. Iguchi S., Mizushima R., Kamada K., Itakura Y., Yoshida A., Uzawa Y., et al. The second Candida auris isolate from aural discharge in Japan. Jpn J Infect Dis. 2018;71(2):174175. DOI: 10.7883/yoken.JJID.2017.466
  • 20. Iguchi S., Mizushima R., Kamada K., Itakura Y., Yoshida A., Uzawa Y., et al. Detection of Candida auris among previously unidentified yeasts isolated from ear discharge specimens in Japan. Open Forum Infect Dis. 2018;5(1):598-599. DOI: 10.1093/ofid/ofy210.1707
  • 21. Kwon Y.J., Shin J.H., Byun S.A., Choi M.J., Won E.J., Lee D., et al. Candida auris clinical isolates from South Korea: identification, antifungal susceptibility, and genotyping. J Clin Microbiol. 2018;57(4):01624-18. DOI: 10.1128/JCM.01624-18
  • 22. Welsh R.M., Sexton D.J., Forsberg K., Vallabhaneni S., Litvintseva A. Insights into the unique nature of the East Asian clade of the emerging pathogenic yeast Candida auris. J Clin Microbiol. 2019;57(4):00007-19. DOI: 10.1128/JCM.00007-19
  • 23. Chowdhary A., Sharma C., Duggal S., Agarwal K., Prakash A., Singh P.K., et al. New clonal strain of Candida auris, Delhi, India. Emerg Infect Dis. 2013;19(10):16701673. DOI: 10.3201/eid1910.130393
  • 24. Lone S.A., Ahmad A. Candida auris – the growing menace to global health. Mycoses. 2019;62(8):620-637. DOI: 10.1111/myc.12904
  • 25. Chowdhary A., Anil Kumar V., Sharma C., Prakash A., Agarwal K., Babu R., et al. Multidrug-resistant endemic clonal strain of Candida auris in India. Eur J Clin Microbiol Infect Dis. 2014;33(6):919-926. DOI: 10.1007/s10096013-2027-1
  • 26. Sarma S., Upadhyay S. Current perspective on emergence, diagnosis and drug resistance in Candida auris. Infect Drug Resist. 2017;10:155-165. DOI: 10.2147/IDR.S116229
  • 27. Khillan V., Rathore N., Kathuria S., Chowdhary A. A rare case of breakthrough fungal pericarditis due to fluconazoleresistant Candida auris in a patient with chronic liver disease. JMM Case Reports. 2014;1(3):1-5. DOI: 10.1099/jmmcr.0.T00018
  • 28. Mathur P., Hasan F., Singh P.K., Malhotra R., Walia K., Chowdhary A. Five-year profile of candidaemia at an Indian trauma centre: high rates of Candida auris blood stream infections. Mycoses. 2018;61(9):674-680. DOI: 10.1111/myc.12790
  • 29. Rudramurthy S.M., Chakrabarti A., Paul R.A., Sood P., Kaur H., Capoor M.R., et al. Candida auris candidaemia in Indian ICUs: analysis of risk factors. J Antimicrob Chemother. 2017;72:1794-1801. DOI: 10.1093/jac/dkx034
  • 30. Chowdhary A., Tarai B., Singh A., Sharma A. Multidrugresistant Candida auris infections in critically ill coronavirus disease patients, India, April-July 2020. Emerg Infect Dis. 2020;26(11):2694-2696. DOI: 10.3201/eid2611.203504
  • 31. Tian S., Rong C., Nian H., Li F., Chu Y., Cheng S., et al. First cases and risk factors of super yeast Candida auris infection or colonization from Shenyang, China. Emerg Microbes Infect. 2018;7(1):128. DOI: 10.1038/s41426018-0131-0
  • 32. Chen Y., Zhao J., Han L., Qi L., Fan W., Liu J., et al. Emergency of fungemia cases caused by fluconazole-resistant Candida auris in Beijing, China. J Infect. 2018;77(6):561-571. DOI: 10.1016/j.jinf.2018.09.002
  • 33. Wang X., Bing J., Zheng Q., Zhang F., Liu J., Yue H., et al. The first isolate of Candida auris in China: clinical and biological aspects. Emerg Microbes Infect. 2018;7(1):93. DOI: 10.1038/s41426-018-0095-0
  • 34. Tan Y.E., Tan A.L. Arrival of Candida auris fungus in Singapore: report of the first 3 cases. Ann Med Singap. 2018;47(7):260-262. PMID: 30120434.
  • 35. Tan Y.E., Teo J.Q., Rahman N.B.A., Ng O.T., Kalisvar M., Tan A.L., et al. Candida auris in Singapore: genomic epidemiology, antifungal drug resistance, and identification using the updated 8.01 VITEK2 system. Int J Antimicrob Agents. 2019;54(6):709-715. DOI: 10.1016/j.ijantimicag.2019.09.016
  • 36. Tang H.J., Lai C.C., Lai F.J., Li S.Y., Liang H.Y., Hsueh P.R. Emergence of multidrug-resistant Candida auris in Taiwan. Int J Antimicrob Agents. 2019;53(5):705-706. DOI: 10.1016/j.ijantimicag.2019.02.011
  • 37. Mohd Tap R., Lim T.C., Kamarudin N.A., Ginsapu S.J., Abd Razak M.F., Ahmad N., et al. A fatal case of Candida auris and Candida tropicalis candidemia in neutropenic patient. Mycopathologia. 2018;183(3):559-564. DOI: 10.1007/s11046-018-0244-y
  • 38. Tantimavanich S., Kitphiboonpun W., Prachayasittikul V. Candida auris: the first resistant Candida. J Med Tech Assoc Thailand. 2018;46(2):6472-6491.
  • 39. Dutta S., Rahman H., Shakhawath Hossain K., Ashraful Haq J. Detection of Candida auris and its antifungal susceptibility: first report from Bangladesh. IMC J Med Sci 2019;13(2):003. DOI: 10.3329/imcjms.v13i2.45276
  • 40. Ben-Ami R., Berman J., Novikov A., Bash E., ShachorMeyouhas Y., Zakin S., et al. Multidrug-resistant Candida haemulonii and C. auris, Tel Aviv, Israel. Emerg Infect Dis. 2017;23(1):195-203. DOI: 10.3201/eid2302.161486
  • 41. Emara M., Ahmad S., Khan Z., Joseph L., Al-Obaid I., Purohit P., et al. Candida auris candidemia in Kuwait, 2014. Emerg Infect Dis. 2015;21(6):1091-1092. DOI: 10.3201/eid2106.150270
  • 42. Khan Z., Ahmad S., Al-Sweih N., Joseph L., Alfouzan W., Asadzadeh M. Increasing prevalence, molecular characterization and antifungal drug susceptibility of serial Candida auris isolates in Kuwait. PLoS One. 2018;13(4):e0195743. DOI: 10.1371/journal.pone.0195743
  • 43. Khan Z., Ahmad S., Benwan K., Purohit P., Al-Obaid I., Bafna R., et al. Invasive Candida auris infections in Kuwait hospitals: epidemiology, antifungal treatment and outcome. Infection. 2018;46(5):641-650. DOI: 10.1007/s15010018-1164-y
  • 44. Mohsin J., Hagen F., Al-Balushi Z.A.M., de Hoog G.S., Chowdhary A., Meis J.F., et al. The first cases of Candida auris candidaemia in Oman. Mycoses. 2017;60(9):569575. DOI: 10.1111/myc.12647
  • 45. Al-Siyabi T., Al Busaidi I., Balkhair A., Al-Muharrmi Z., Al-Salti M., Al'Adawi B. First report of Candida auris in Oman: clinical and microbiological description of five candidemia cases. J Infect. 2017;75(4):373-376. DOI: 10.1016/j.jinf.2017.05.016
  • 46. Osei Sekyere J. Candida auris: a systematic review and meta-analysis of current updates on an emerging multidrugresistant pathogen. Microbiologyopen. 2018;7(4):e00578. DOI: 10.1002/mbo3.578
  • 47. Abdalhamid B., Almaghrabi R., Althawadi S., Omrani A. First report of Candida auris infections from Saudi Arabia. J Infect Public Health. 2018;11(4):598-599. DOI: 10.1016/j.jiph.2018.05.010
  • 48. Alatoom A., Sartawi M., Lawlor K., Abdel W.L., Thomsen J., Nusair A., et al. Persistent candidemia despite appropriate fungal therapy: first case of Candida auris from the United Arab Emirates. Int J Infect Dis. 2018;70:36-37. DOI: 10.1016/j.ijid.2018.02.005
  • 49. Abastabar M., Haghani I., Ahangarkani F., Rezai M.S., Taghizadeh Armaki M., Roodgari S., et al. Candida auris otomycosis in Iran and review of recent literature. Mycoses. 2019;62:101-105. DOI: 10.1111/myc.12886
  • 50. Shaukat A., Al Ansari N., Al Wali W., Karic E., El Madhoun I., Mitwally H., et al. Experience of treating Candida auris cases at a general hospital in the state of Qatar. IDCases. 2020;23:e01007. DOI: 10.1016/j.idcr.2020.e01007
  • 51. Salah H., Sundararaju S., Dalil L., Salameh S., Al-Wali W., Tang P., et al. Genomic epidemiology of Candida auris in Qatar reveals hospital transmission dynamics and a South Asian origin. J Fungi (Basel). 2021;7(3):240. DOI: 10.3390/jof7030240
  • 52. Allaw F., Kara Zahreddine N., Ibrahim A., Tannous J., Taleb H., Bizri A.R., et al. First Candida auris outbreak during a COVID-19 pandemic in a tertiary-care center in Lebanon. Pathogens. 2021;3;10(2):157. DOI: 10.3390/pathogens10020157
  • 53. Kohlenberg A., Struelens M.J., Monnet D.L., Plachouras D., The Candida auris survey collaborative group. Candida auris: epidemiological situation, laboratory capacity and preparedness in European Union and European Economic Area countries, 2013 to 2017. Euro Surveill. 2018; 23(13):18-00136. DOI: 10.2807/1560-7917.ES.2018.23.13.18-00136
  • 54. Plachouras D., Lötsch F., Kohlenberg A., Monnet D.L., the Candida auris survey collaborative group. Candida auris: epidemiological situation, laboratory capacity and preparedness in the European Union and European Economic Area, January 2018 to May 2019. Euro Surveill. 2020;25(12):2000240. DOI: 10.2807/1560-7917.ES.2020.25.12.2000240
  • 55. Schelenz S., Hagen F., Rhodes J.L., Abdolrasouli A., Chowdhary A., Hall A., et al. First hospital outbreak of the globally emerging Candida auris in a European hospital. Antimicrob Resist Infect Control. 2016;5:35. DOI: 10.1186/s13756-016-0132-5
  • 56. Borman A.M., Johnson E.M. Candida auris in the UK: Introduction, dissemination, and control. PLoS Pathog. 2020;16(7):e1008563. DOI: 10.1371/journal.ppat.1008563
  • 57. Ruiz-Gaitán A., Moret A.M., Tasias-Pitarch M., AleixandreLópez A.I., Martínez-Morel H. Calabuig E., et al. An outbreak due to Candida auris with prolonged colonization and candidaemia in a tertiary care European hospital. Mycoses. 2018;61(7):498-505. DOI: 10.1111/myc.12781
  • 58. Hernando-Ortiz A., Mateo E., Perez-Rodriguez A., de Groot P.W.J. , Quindós G., Eraso E. Virulence of Candida auris from different clinical origins in Caenorhabditis elegans and Galleria mellonella host models. Virulence. 2021;12(1):1063-1075. DOI: 10.1080/21505594.2021.1908765
  • 59. Riat A., Neofytos D., Coste A., Harbarth S., Bizzini A., Grandbastien B., et al. First case of Candida auris in Switzerland: discussion about preventive strategies. Swiss Med Wkly. 2018;148:w14622. DOI: 10.4414/smw.2018.14622
  • 60. Govender N.P., Magobo R.E., Mpembe R., Mhlanga M., Matlapeng P., Corcoran C., et al. Candida auris in South Africa, 2012-2016. Emerg Infect Dis. 2018;24(11):20362040. DOI: 10.3201/eid2411.180368
  • 61. van Schalkwyk E., Mpembe R.S., Thomas J., Shuping L., Ismail H., Lowman W., et al. Epidemiologic shift in candidemia driven by Candida auris, South Africa, 20162017. Emerg Infect Dis. 2019;25(9):1698-1707. DOI: 10.3201/eid2509.190040
  • 62. Okinda N., Kagotho E., Castanheira M., Njuguna A., Omuse G., Makau P., et al. Candidemia at a referral hospital in sub-Saharan Africa: emergence of Candida auris as a major pathogen. Proceedings of 24th ECCMID, Barcelona, Spain, 2014. Poster. P0065.
  • 63. Meis J., El-Kholy M., Shawky S., Fayed A. Candida auris bloodstream infection in Egypt. J Fungi (Basel). 2019;5(4):310-311. DOI: 10.3390/jof5040095
  • 64. Ali M Badri. First detection of emergent fungal pathogen Candida auris in Khartoum State, Sudan. Am J Biomed Sci & Res. 2019;6(1). DOI: 10.34297/AJBSR.2019.06.000982
  • 65. Calvo B., Melo A.S., Perozo-Mena A., Hernandez M., Francisco E.C., Hagen F., et al. First report of Candida auris in America: clinical and microbiological aspects of 18 episodes of candidemia. J Infect. 2016;73:369-374. DOI: 10.1016/j.jinf.2016.07.008
  • 66. Morales-López S.E., Parra-Giraldo C.M., Ceballos-Garzón A., Martínez H.P., Rodríguez G.J., Álvarez-Moreno C.A., et al. Invasive infections with multidrug-resistant yeast Candida auris, Colombia. Emerg Infect Dis. 2017;23:162164. DOI: 10.3201/eid2301.161497
  • 67. Parra-Giraldo C.M., Valderrama S.L., Cortes-Fraile G., Garzón J.R., Ariza B.E., Morio F., et al. First report of sporadic cases of Candida auris in Colombia. Int J Infect Dis. 2018;69:63-67. DOI: 10.1016/j.ijid.2018.01.034
  • 68. Escandón P., Cáceres D.H., Espinosa-Bode A., Rivera S., Armstrong P., Vallabhaneni S., et al. Notes from the field: surveillance for Candida auris – Colombia, September 2016 – May 2017. MMWR Morb Mortal Wkly Rep. 2018;67(15):459-460. DOI: 10.15585/mmwr.mm6715a6
  • 69. Armstrong P.A., Rivera S.M., Escandon P., Caceres D.H., Chow N., Stuckey M.J., et al. Hospital-associated multicenter outbreak of emerging fungus Candida auris, Colombia, 2016. Emerg Infect Dis. 2019;(7):1339-1346. DOI: 10.3201/eid2507.180491
  • 70. Pan American Health Organization / World Health Organization. Epidemiological Alert: Candida auris outbreaks in health care services in the context of the COVID-19 pandemic. 6 February 2021, Washington, D.C. PAHO/WHO. Available at: www.paho.org/en/documents/epidemiological-alert-candida-auris-outbreakshealth-care-services-context-covid-19.
  • 71. de Almeida J.N. Jr., Francisco E.C., Hagen F., Brandão I.B., Pereira F.M., Presta Dias P.H., et al. Emergence of Candida auris in Brazil in a COVID-19 intensive care unit. J Fungi (Basel). 2021;7(3):220. DOI: 10.3390/jof7030220
  • 72. Chow N.A., Gade L., Tsay S.V., ForsbergK., Greenko J.A., Southwick K.L., et al. Multiple introductions and subsequent transmission of multidrug-resistant Candida auris in the USA: a molecular epidemiological survey. Lancet Infect Dis. 2018;18:1377-1384. DOI: 10.1016/S14733099(18)30597-8
  • 73. Schwartz I.S., Hammond G.W. First reported case of multidrug-resistant Candida auris in Canada. Can Commun Dis Rep. 2017;43:150-153. DOI: 10.14745/ccdr.v43i78a02
  • 74. Garcia-Jeldes H.F., Mitchell R., McGeer A., Rudnick W., Amaratunga K., Vallabhaneni S., et al. Prevalence of Candida auris in Canadian acute care hospitals among at-risk patients, 2018. Antimicrob Resist Infect Control. 2020;9(1):82. DOI: 10.1186/s13756-020-00752-3
  • 75. Araúz A.B., Caceres D.H., Santiago E., Armstrong P., Arosemena S., Ramos C., et al. Isolation of Candida auris from 9 patients in Central America: importance of accurate diagnosis and susceptibility testing. Mycoses. 2018;61:4447. DOI: 10.1111/myc.12709
  • 76. Ayala-Gaytán J.J., Montoya A.M., Martínez-Resendez M.F., Guajardo-Lara C.E., de J Treviño-Rangel R., SalazarCavazos L., et al. First case of Candida auris isolated from the bloodstream of a Mexican patient with serious gastrointestinal complications from severe endometriosis. Infection. 2020;49(3):523-525. DOI: 10.1007/s15010020-01525-1
  • 77. Villanueva-Lozano H., Treviño-Rangel R.J., González G.M., Ramírez-Elizondo M.T., Lara-Medrano R., AlemanBocanegra M.C., et al. Outbreak of Candida auris infection in a COVID-19 hospital in Mexico. Clin Microbiol Infect. 2021;27(5):813-816. DOI: 10.1016/j.cmi.2020.12.030
  • 78. Heath C.H., Dyer J.R., Pang S., Coombs G.W., Gardam D.J. Candida auris sternal osteomyelitis in a man from Kenya visiting Australia, 2015. Emerg Infect Dis. 2019;25:192194. DOI: 10.3201/eid2501.181321
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