Новые лекарственные формы позаконазола: краткий клинико-фармакологический обзор | КМАХ

Новые лекарственные формы позаконазола: краткий клинико-фармакологический обзор

Клиническая Микробиология и Антимикробная Химиотерапия. 2016; 18(4):249-269

​ Веселов А.В.
азолы антимикотики инвазивные микозы позаконазол фармакокинетика фармакодинамика
Раздел
Антимикробные препараты
Тип
Журнальная статья
Публикация
Клиническая Микробиология и Антимикробная Химиотерапия. 2016; 18(4):249-269

Аннотация

Позаконазол является триазолом второго поколения с широким спектром активности, который впервые появился на рынке в 2005 г. в виде суспензии для перорального приёма. Несмотря на ряд успехов, достигнутых в рамках проведенных клинических исследований, проблемы, связанные как с особенностями фармакокинетики пероральной суспензии, так и с невозможностью приёма внутрь препарата у отдельных пациентов, привели к понятным ограничениям использования позаконазола в клинической практике. В период с 2013 по 2014 гг. в странах Европы и в США были одобрены для применения новая таблетированная форма позаконазола и его раствор для внутривенного введения. Появление таблетки с улучшенными фармакокинетическими параметрами, а также внутривенной формы препарата для применения как в рамках ступенчатой терапии, так и у пациентов, в силу тех или иных причин не имеющих возможности принимать позаконазол внутрь, в значимой степени оказало положительное влияние на проблему выбора антимикотиков для терапии и профилактики инвазивных грибковых инфекций. На настоящий момент новые лекарственные формы позаконазола не зарегистрированы на территории РФ, однако представляется целесообразным ознакомить практикующих врачей с их клинико-фармакологическими характеристиками.

Веселов Александр Валерьевич

НИИ антимикробной химиотерапии ФГБОУ ВО СГМУ Минздрава России, Смоленск, Россия

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