Мёд в лечении инфицированных ран | КМАХ

Мёд в лечении инфицированных ран

Клиническая Микробиология и Антимикробная Химиотерапия. 2014; 16(3):219-228

​ Привольнев В.В., Даниленков Н.В.
мёд антимикробная активность раневая инфекция
Раздел
Антимикробные препараты
Тип
Журнальная статья
Публикация
Клиническая Микробиология и Антимикробная Химиотерапия. 2014; 16(3):219-228

Аннотация

В последнее десятилетие исследователи «заново открыли» ряд антисептиков и методов лечения инфицированных ран, известных с глубокой древности. Одним из таких антимикробных веществ является пчелиный мёд. В публикации представлен взгляд на настоящее и потенциальное будущее применения мёда в лечении инфицированных ран с позиций доказательной медицины.

  • 1. Gunther R.T. The Greek Herbal of Dioscorides. New York: Hafner; 1934 (reprinted 1959).
  • 2. Molan P.C. The antibacterial activity of honey. The nature of the antibacterial activity. Bee World 1992; 73(1):5-28.
  • 3. Molan P.C. The evidence and the rationale for the use of honey as a wound dressing. Wound Practice and Research 2011; 19(4):204–20.
  • 4. Molan P.C. The role of honey in the management of wounds. J Wound Care 1999; 8:415–8.
  • 5. Dustmann J.H. Antibacterial effect of honey. Apiacta 1979; 14:7-11.
  • 6. Bose B. Honey or sugar in treatment of infected wounds? Lancet 1982; 1:963.
  • 7. Condon R.E. Curious interaction of bugs and bees. Surgery 1993; 113(2):234-5.
  • 8. Green A.E. Wound healing properties of honey. Br J Surg 1988; 75(12):1278.
  • 9. Keast-Butler J. Honey for necrotic malignant breast ulcers. Lancet 1980; 2(8198):809.
  • 10. Mossel D.A. Honey for necrotic breast ulcers. Lancet 1980; 2(8203):1091.
  • 11. Seymour F.I, West K.S. Honey – its role in medicine. Med Times 1951; 79:104-7.
  • 12. Somerfield S.D. Honey and healing. J R Soc Med 1991; 84(3):179.
  • 13. Tovey F.I. Honey and healing. J R Soc Med 1991; 84(7):447.
  • 14. Chirife J., Herszage L., Joseph A., Kohn E.S. In vitro study of bacterial growth inhibition in concentrated sugar solutions: microbiological basis for the use of sugar in treating infected wounds. Antimicrob Agents Chemother 1983; 23(5):766-73.
  • 15. Efem S.E. Clinical observations on the wound healing properties of honey. Br J Surg 1988; 75(7):679-81.
  • 16. Cavanagh D., Beazley J., Ostapowicz F. Radical operation for carcinoma of the vulva. A new approach to wound healing. J Obstet Gynaecol Br Commonw 1970; 77(11):1037-40.
  • 17. Armon P.J. The use of honey in the treatment of infected wounds. Trop Doct 1980; 10(2):91.
  • 18. Braniki F.J. Surgery in Western Kenya. Ann R Coll Surg Engl 1981; 63:348-52.
  • 19. Cooper R.A., Molan P.C., Harding K.G. Antibacterial activity of honey against strains of Staphylococcus aureus from infected wounds. J R Soc Med 1999; 92(6):283-5.
  • 20. Привольнев В.В., Каракулина Е.В. Основные принципы местного лечения ран и раневой инфекции. Клиническая Микробиология и Антимикробная Химиотерапия 2011; 13(3):214-22.
  • 21. Sackett W.G. Honey as a carrier of intestinal diseases. Bull Colorado State Univ Agric Exp Stn 1919; 252:1-18.
  • 22. White J.W, Subers M.H, Schepartz A.I. The identification of inhibine, the antibacterial factor in honey, as hydrogen peroxide and its origin in a honey glucoseoxidase system. Biochim Biophys Acta 1963; 73:57-70.
  • 23. Dold H., Witzenhausen R. Ein Verfahren zur Beurteilung der еrtlichen inhibitorischen (keimvermehrungshemmenden) Wirkung von Honigsorten verschiedener Herkunft [Method of evaluation of the local inhibitory (antibacterial) substances of honeys from various origins]. Z Hyg Infektionskr 1955; 141:333-7.
  • 24. Postmes T.J, Bosch M.M.C, Dutrieux R., van Baare J., Hoekstra M.J. Speeding up the healing of burns with honey. An experimental study with histological assessment of wound biopsies. In: Mizrahi A., Lensky Y., editors. Bee Products: Properties, Applications and Apitherapy. New York: Plenum Press, 1997; 27-37.
  • 25. Turner F.J. Hydrogen Peroxide and Other Oxidant Disinfectants (3rd ed). Philadelphia: Lea and Febiger, 1983.
  • 26. Salahudeen A.K., Clark E.C., Nath K.A. Hydrogen peroxide-induced renal injury. A protective role for pyruvate in vitro and in vivo. J Clin Invest 1991; 88(6):1886-93.
  • 27. Блатун Л.А. Местное медикаментозное лечение ран. Хирургия. Журнал им. Н.И. Пирогова 2011; 4:51-59
  • 28. Светухин А.М., Блатун Л.А., Адамян А.А. Раны, инфекции, лечебные повязки. Аптечное дело 2002; 10:16
  • 29. Bunting C.M. The production of hydrogen peroxide by honey and its relevance to wound healing. MSc thesis. University of Waikato. 2001.
  • 30. Frankel S., Robinson G.E, Berenbaum M.R. Antioxidant capacity and correlated characteristics of 14 unifloral honeys. J Apic Res 1998; 37(1):27-31.
  • 31. Henriques A. Free radical production and quenching in honeys with wound healing potential. J Antimicrob Chemother 2006; 58(4):773–7
  • 32. van den Berg A.J. An in vitro examination of the antioxidant and anti-inflammatory properties of buckwheat honey. J Wound Care 2008; 17(4):172–8
  • 33. Hyslop P.A., Hinshaw D.B., Scraufstatter I.U., Cochrane C.G., Kunz S., Vosbeck K. Hydrogen peroxide as a potent bacteriostatic antibiotic: implications for host defense. Free Radic Biol Med 1995; 19(1):31-7.
  • 34. Kumar A., Sharma V.K., Singh H.P., Prakash P., Singh S.P. Efficacy of some indigenous drugs in tissue repair in buffaloes. Indian Vet J 1993; 70(1):42-4.
  • 35. Kandil A., El-Banby M., Abdel-Wahed K., AbouSehly G., Ezzat N. Healing effect of true floral and false non-floral honey on medical wounds. J Drug Res (Cairo) 1987; 17(1-2):71-5.
  • 36. Abuharfeil N., Al-Oran R., Abo-Shehada M. The effect of bee honey on the proliferative activity of human B- and T-lymphocytes and the activity of phagocytes. Food Agric Immunol 1999; 11:169-77.
  • 37. Tonks A., Cooper R.A., Price A.J., Molan P.C., Jones K.P. Stimulation of tnf-alpha release in monocytes by honey. Cytokine 2001; 14(4):240-2.
  • 38. Ryan G.B., Majno G. Inflammation. Michigan: Upjohn, 1977.
  • 39. Gethin G.T., Cowman S. Manuka honey vs. hydrogel – a prospective, open label, multicentre, randomised controlled trial to compare desloughing efficacy and healing outcomes in venous ulcers. J Clin Nurs 2009; 18(3):466-74.
  • 40. Tarnuzzer R.W., Schultz G.S. Biochemical analysis of acute and chronic wound environments. Wound Repair Regen 1996; 4(3):321-5.
  • 41. Floris I., Prota R. Sul miele amaro di Sardegna [Bitter honey from Sardegna]. Apic Mod 1989; 80(2):55-67.
  • 42. Fotidar M.R., Fotidar S.N. ‘Lotus’ honey. Indian Bee J 1945; 7:102.
  • 43. Abbas T. Royal treat. Living in the Gulf 1997; 50-1.
  • 44. Mavric E., Wittmann S., Barth G. Identification and quantification of methylglyoxal as the dominant antibacterial constituent of Manuka (Leptospermum scoparium) honeys from New Zealand Molecular Nutrition & Food Research 2008; 52:483-89.
  • 45. Willix D.J., Molan P.C., Harfoot C.G. A comparison of the sensitivity of wound-infecting species of bacteria to the antibacterial activity of manuka honey and other honey. J Appl Bacteriol 1992; 73(5):388-94.
  • 46. Cooper R.A., Molan P.C. The use of honey as an antiseptic in managing Pseudomonas infection. J Wound Care 1999; 8(4):161-4.
  • 47. Allen K.L., Hutchinson G., Molan P.C. The potential for using honey to treat wounds infected with MRSA and VRE. First World Wound Healing Congress, 2000; Melbourne, Australia.
  • 48. Cooper R.A., Halas E., Davies R., Molan P.C., Harding K.G. The inhibition of Gram-positive cocci of clinical importance by honey. First World Wound Healing Congress, 2000; Melbourne, Australia.
  • 49. Cooper R.A. The efficacy of honey in inhibiting strains of Pseudomonas aeruginosa from infected burns. J Burns Care Rehabil 2002; 23:366-70.
  • 50. Blair S.E. The unusual antibacterial activity of medicalgrade Leptospermum honey: antibacterial spectrum, resistance and transcriptome analysis. Eur J Clin Microbiol Infect Dis 2009; 28(10):1199-208.
  • 51. Henriques A.F. The intracellular effects of manuka honey on Staphylococcus aureus. Eur J Clin Microbiol Infect Dis 2010; 29(1):45-50.
  • 52. George N.M., Cutting K.F. Antibacterial honey (MedihoneyTM): in vitro activity against clinical isolates of MRSA, VRE, and other multiresistant gram-negative organisms including Pseudomonas aeruginosa. Wounds 2007; 19(9): 231-6
  • 53. Sherlock O. Comparison of the antibacterial activity of Ulmo honery from Chile and manuka honey against methicillin-resistant Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. BMC Complement Altern Med 2010; 2(10):47.
  • 54. Jenkins R. Manuka honey inhibits cell division in methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother 2011; 66(11):2536-4.
  • 55. French V.M. The antibacterial activity of honey against coagulase-negative staphylococci. J Antimicrob Chemother 2005; 56:228-31.
  • 56. Cooper R.A. Testing the susceptibility to manuka honey of streptococci isolated from wound swab. J ApiProduct & ApiMedical Science 2011; 3(3):117–22.
  • 57. Привольнев В.В., Родин А.В., Каракулина Е.В. Местное применение антибиотиков в лечении инфекций костной ткани. Клин микробиол и антимикроб химиотер 2012; 14(2):118-32.
  • 58. Merckoll P. Bacteria, biofilm and honey: a study of the effects of honey on ‘planktonic’ and biofilm-embedded chronic wound bacteria. Scand J Infect Dis 2009; 41(5):341-7.
  • 59. Alandejani T. Effectiveness of honey on Staphylococcus aureus and Pseudomonas aeruginosa biofilms. Otolaryngol Head Neck Surg 2009; 141(1):114-8.
  • 60. Okhiria O.A. Honey modulates biofilms of Pseudomonas aeruginosa in a time and dose dependent manner. J ApiProduct & ApiMedical Science 2009; 1(1):6-10.
  • 61. Cooper R. Inhibition of biofilms through the use of manuka honey. Wounds UK 2011; 7(1):24-32.
  • 62. Maddocks S.E. Manuka honey inhibits the development of Streptococcus pyogenes biofilms and causes reduced expression of two fibronectin binding proteins. Microbiology 2012; 158:781-90.
  • 63. Jervis-Bardy J. Methylglyoxal-infused honey mimics the anti-Staphylococcus aureus biofilm activity of manuka honey: potential implication in chronic rhinosinusitis. Laryngoscope 2011; 121(5):1104-7.
  • 64. Hutton D.J. Treatment of pressure sores. Nurs Times 1966; 62(46):1533-4.
  • 65. Efem S.E. Recent advances in the management of Fournier’s gangrene: preliminary observations. Surgery 1993; 113(2):200-4.
  • 66. Harris S. Honey for the treatment of superficial wounds: a case report and review. Primary Intention 1994; 2(4):18- 23.
  • 67. Dunford C., Cooper R., Molan P. Using honey as a dressing for infected skin lesions. Nurs Times 2000; 96(14 Suppl):7-9.
  • 68. Dunford C., Cooper R., White R.J., Molan P. The use of honey in wound management. Nurs Standard 2000; 15(11):63-8.
  • 69. Natarajan S., Williamson D., Grey J.A., Harding K.G., Cooper R.A. Healing of an MRAS-colonised, hydroxyurea-induced leg ulcer with honey. J Dermat Treat 2001; 12:33-6.
  • 70. Al-Waili N.S., Saloom K.Y. Effects of topical honey on post-operative wound infections due to gram positive and gram negative bacteria following caesarean sections and hysterectomies. Eur J Med Res 1999; 4(3):126-30.
  • 71. Subrahmanyam M. A prospective randomised clinical and histological study of superficial burn wound healing with honey and silver sulfadiazine. Burns 1998; 24(2):157-61.
  • 72. Ефименко Н.А., Привольнев В.В. Гангрена Фурнье. Клиническая Микробиология и Антимикробная Химиотерапия 2008; 10(1):25-34.
  • 73. Привольнев В.В., Савкин В.А.. Клиническая значимость и опыт лечения больных с гангреной Фурнье. Клиническая медицина 2008; 3(15):120-5.
  • 74. Oryan A., Zaker S.R. Effects of topical application of honey on cutaneous wound healing in rabbits. Zentralbl Veterinarmed A 1998; 45:181-8.
  • 75. Rashad U.M., Al-Gezawy S.M., El-Gezawy E., Azzaz A.N. Honey as topical prophylaxis against radiochemotherapyinduced mucositis in head and neck cancer. J Laryngol Otol 2009; 123:223-8.
  • 76. Ingle R., Levin J., Polinder K. Wound healing with honey-a randomised controlled trial. S Afr Med J 2006; 96:831-5.
  • 77. Marshall C., Queen J., Manjooran J. Honey vs povidine iodine following toenail surgery. Wounds 2005; 1(1):10-8.
  • 78. Jull A.B., Rodgers A., Walker N. Honey as a topical treatment for wounds. Cochrane Database Syst Rev 2008(4): CD005083.
  • 79. Mashhood A.A., Khan T.A., Sami A.N. Honey compared with 1% silver sulfadiazine cream in the treatment of superficial and partial thickness burns. J Pak Assoc Dermatol 2006; 16:14-9.
  • 80. Subrahmanyam M. Honey impregnated gauze versus polyurethane film (OpSite) in the treatment of burns-a prospective randomised study. Br J Plast Surg 1993; 46:322-3.
  • 81. Bangroo A.K., Katri R., Chauhan S. Honey dressing in pediatric burns. J Indian Assoc Pediatr Surg 2005; 10:172-5.
  • 82. Subrahmanyam M., Sahapure A.G., Nagane N.S., Bhagwat V.R., Ganu J.V. Effects of topical application of honey on burn wound healing. Ann Burns Fire Disasters 2001; 14(3):22-4.
  • 83. Привольнев В.В., Решедько Г.К., Земляной А.Б., Бублик Е.В. Лечение пациентов с синдромом диабетической стопы в г. Смоленске по результатам анкетирования. Доктор.Ру 2012; 1(69):65-70.
  • 84. Shukrimi A., Sulaiman A.R., Halim A.Y., Azril A. A comparative study between honey and povidone iodine as dressing solution for Wagner type II diabetic foot ulcers. Med J Malaysia 2008; 63(1):44-6.
  • 85. Bauer L., Kohlich A., Hirschwehr R., et al. Food allergy to honey: pollen or bee products? Characterization of allergenic proteins in honey by means of immunoblotting. J Allergy Clin Immunol 1996; 97(1 Pt 1):65-73.
  • 86. Betts J.A., Molan P.C. A pilot trial of honey as a wound dressing has shown the importance of the way honey is applied to wounds. 11th Conference of the European Wound Management Association, 2001; Dublin, Ireland.
  • 87. Molan P.C., Allen K.L. The effect of gamma-irradiation on the antibacterial activity of honey. J Pharm Pharmacol 1996; 48(11):1206-9.
Просмотров
0 Аннотация
0 PDF
0 Цитирования
Поделились