Аннотация
Инфекционные осложнения, вызванные грам(+) возбудителями, представляют серьёзную проблему для пациентов в отделениях гемодиализа, нуждающихся в постоянном сосудистом доступе. Одной из основных проблем при этом является терапия инфекций, вызванных штаммами Staphylococcus aureus, резистентными к бета-лактамам (MRSA). Ключевое значение для лечения таких инфекций имеет ванкомицин. Однако традиционный подход к дозированию ванкомицина у пациентов на гемодиализе недостаточно эффективен в настоящее время. В большинстве случаев он не позволяет получать адекватные остаточные концентрации в крови ванкомицина и обеспечивать условия для успешной эрадикации штаммов MRSA с МПК ванкомицина ≥1 мг/л. Разработан и валидирован в клинических условиях новый протокол дозирования ванкомицина у пациентов, нуждающихся в гемодиализе.
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