Аннотация
Проблема резистентности микроорганизмов ко многим классам антимикробных препаратов (АМП) приобретает все более угрожающий характер, особенно среди возбудителей тяжелых нозокомиальных инфекций в стационаре. Среди новых АМП, появившихся в клинической практике, особое место занимает тигециклин — первый и единственный глицилциклин, активный в отношении многих грамположительных и грамотрицательных микроорганизмов, включая штаммы, обладающие механизмами резистентности к другим классам антибиотиков. В данном обзоре представлены основные сведения, касающиеся антибактериальной активности, фармакокинетики и фармакодинамики, терапевтической эффективности, безопасности и переносимости тигециклина, а также рассмотрено его место в современной клинической практике.
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