Эпидемиология возбудителей кандидозов и их чувствительность к азолам: результаты исследования ARTEMIS Disk в России

Клиническая Микробиология и Антимикробная Химиотерапия. 2005; 7(1):68-76

​ Веселов А.В., Мултых И.Г., Клясова Г.А., Агапова Е.Д., Кречикова О.И., Климко Н.Н., Дмитриева Н.В., Ильина В.Н., Розанова С.М., Козлов С.Н.
Candida spp эпидемиология флуконазол вориконазол
Раздел
Антибиотикорезистентность
Тип
Журнальная статья
Публикация
Клиническая Микробиология и Антимикробная Химиотерапия. 2005; 7(1):68-76

Аннотация

В 2003 г. восемь российских лечебных центров в Екатеринбурге, Иркутске, Краснодаре, Новосибирске, Москве, Санкт-Петербурге и Смоленске приняли участие в исследовании ARTEMIS Disk 2003, целью которого был мониторинг резистентности клинических штаммов грибов рода Candida к флуконазолу и вориконазолу с использованием диско-диффузионного метода. Всего было протестировано 1223 штамма Candida spp., выделенных из половых путей (29%), верхних отделов дыхательных путей (20%), нижних отделов желудочно-кишечного тракта (16%), нижних отделов дыхательных путей (13%) и из мочевыводящих путей (9%). Доминирующими видами были: C.albicans (73,7%), C.glabrata (5,2%), C.parapsilosis (3%) и C.krusei (2,8%). C.albicans, являясь ведущим возбудителем кандидозов, сохраняет высокую чувствительность к флуконазолу (98,9% чувствительных штаммов). Наименьшая чувствительность к флуконазолу отмечена у C.krusei (6% чувствительных штаммов) и C.glabrata (61% чувствительных штаммов). Вориконазол был высокоактивен в отношении всех видов грибов рода Candida, включая резистентные к флуконазолу штаммы (его МПК50 и МПК90 для большинства штаммов были менее 0,1 и 0,5 мкг/мл соответственно).

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