Аннотация
Моксифлоксацин – новый 8-метоксихинолон широкого спектра действия с высокой активностью в отношении как грам(+) и грам(–) аэробов, так и внутриклеточных возбудителей и анаэробов. Обладает активностью в отношении микроорганизмов, резистентных к другим классам антибактериальных препаратов, включая пенициллино- и макролидорезистентные пневмококки и β-лактамазопродуцирующие штаммы Haemophilus influenzae. Высокая активность против перечисленных возбудителей и хороший фармакокинетический профиль позволяют применять моксифлоксацин для терапии респираторных инфекций. Одним из подходов является ступенчатая терапия, при которой моксифлоксацин, по данным многочисленных контролируемых клинических исследований, продемонстрировал высокую клиническую эффективность и безопасность у пациентов с внебольничной пневмонией. В статье представлен обзор результатов клинических исследований ступенчатой терапии моксифлоксацином при лечении внебольничной пневмонии и сделана попытка оценить возможные перспективы его дальнейшего применения.
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