Значение ферментативной модификации аминогликозидов в развитии резистентности у бактерий | КМАХ

Значение ферментативной модификации аминогликозидов в развитии резистентности у бактерий

Клиническая Микробиология и Антимикробная Химиотерапия. 1999; 1(1):40-50

​ Решедько Г.К.
антибиотики аминогликозиды антибиотикорезистентность
Раздел
Антибиотикорезистентность
Тип
Журнальная статья
Публикация
Клиническая Микробиология и Антимикробная Химиотерапия. 1999; 1(1):40-50

Аннотация

Аминогликозиды являются группой антибактериальных препаратов, широко используемых в клинической практике для лечения инфекционных болезней. Однако их применение сопряжено с рядом проблем: токсичностью, фармакокинетическими особенностями и резистентностью микроорганизмов. В настоящей работе рассматриваются механизмы устойчивости возбудителей инфекций к аминогликозидам, клиническое значение основного механизма резистентности – ферментативной модификации молекулы аминогликозидных антибиотиков.

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