Pseudomonas aeruginosa

Susceptibility to antibiotic combinations among nosocomial carbapenemase-producing Gram-negative bacteria isolated in Belarus

Objective. To assess a susceptibility to antibiotic combinations in nosocomial carbapenemase-producing Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii isolates using a modified method of multiple combination bactericidal testing (MCBT). Materials and Methods. A total of 178 isolates (63 K. pneumoniae isolates, 31 P. aeruginosa isolates, 84 A. baumannii isolates) obtained in the 2013-2017 from hospitalized patients in 28 public health organizations in 4 Belarus regions were included in the study.

Pseudomonas aeruginosa: the history of one of the most successful nosocomial pathogens in Russian hospitals

Pseudomonas aeruginosa is recognized as one of the six most important pathogens in terms of antimicrobial resistance («ESKAPE» pathogens), and included by WHO in the group of microorganisms for which the need for development of new antimicrobial …

Mechanisms and regulation of antimicrobial resistance in Pseudomonas aeruginosa

Pseudomonas aeruginosa is a dangerous opportunistic pathogen. One of the most negative clinically significant features of P. aeruginosa is associated with the rapid acquisition of antimicrobial resistance. This review provides an analysis of current …

Antimicrobial resistance of nosocomial Pseudomonas aeruginosa isolates in Russia: results of multicenter epidemiological study «MARATHON» 2013-2014

Pseudomonas aeruginosa is the most abundant bacterial species causing nosocomial infections in Russia. In this paper, we report the data on antimicrobial susceptibility of 743 isolates of P. aeruginosa collected in 63 hospitals of 22 cities of Russia …

The role of type III secretion system in the development of nosocomial infections, caused by multiresistant Pseudomonas aeruginosa strains

Type III Secretion System (TTSS) is a key pathogenicity factor of Pseudomonas aeruginosa. The suppression of the activity of TTSS would potentially allow block the infection independently on the presence of antimicrobial resistance. To study the role …

Bacteriophage Preparations and Antibiotic Combinations: In vitro Activity Against Extensively Drug-Resistant Isolates of Pseudomonas aeruginosa ST235

The activity of 11 antibiotics combinations and 4 commercially available preparations for phagotherapy in regard to metallo-beta-lactamase (MBL) producing Pseudomonas aeruginosa clinical isolates of sequence type 235 (ST 235) belonging to the clonal …

Pseudomonas aeruginosa: Pathogenicity, Pathogenesis and Diseases

Pseudomonas aeruginosa is one of the most important pathogens causing opportunistic infections. This literature review contains analysis of articles on molecular characteristics of P. aeruginosa virulence factors, as well as the pathogenesis of …

Antimicrobial Resistance of Nosocomial Pseudomonas aeruginosa Isolates in Russia: Results of National Multicenter Surveillance Study «MARATHON» 2011–2012

Pseudomonas aeruginosa is the most abundant bacterial species causing nosocomial infections in Russia. In this paper, we report the data on antimicrobial susceptibility of 343 isolates of P. aeruginosa collected in 25 hospitals of 18 cities of Russia …

Administration of Antimicrobials into Respiratory Tract: Methods to Improve Efficacy in the Treatment of Hospital-Acquired Pneumonia

Despite the availability of substantial theoretical benefits, the method of antibacterial administration via the respiratory tract to treat acute pneumonia has yet to be widely implemented in clinical practice. The introduction of the method is …

Properties of Pseudomonas aeruginosa Strains Causing Nosocomial Infections in Surgical Wards in Federal Scientific Center of Transplantology and Bioartificial Organs

Pseudomonas aeruginosa is the opportunistic microorganism dominating in intensive care units. The present research has been devoted to studying of the causes of long-lasting circulation of certain genotype of P. aeruginosa strains in Federal …