Pseudomonas aeruginosa

Objective. To characterize the population structure and determine the genetic mechanisms of carbapenem resistance in nosocomial isolates of P. aeruginosa collected in Moscow in 2012-2016. Materials and methods. Carbapenem-resistant isolates were collected in two pediatric hospitals in Moscow. Antibiotics susceptibility of P. aeruginosa isolates was assessed using the E-tests and disk-diffusion method. Multilocus sequence typing (MLST) was used for genotyping of the isolates. The presence of metallo-betalactamase (MBL) genes was determined using real-time PCR.

Ceftolozane/tazobactam is a new combined antibacterial agent for the treatment of infections caused by gram-negative microorganisms, P. aeruginosa in particular, including strains resistant to other clinically available antimicrobials. In this paper …

P. aeruginosa is not only intrinsically resistant to many groups of antimicrobials, but is also extremely capable in acquiring resistance to almost all antibacterial agents that are used for the therapy of infections caused by this pathogen, making …

Objective. To assess a susceptibility to antibiotic combinations in nosocomial carbapenemase-producing Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii isolates using a modified method of multiple combination bactericidal testing (MCBT). Materials and Methods. A total of 178 isolates (63 K. pneumoniae isolates, 31 P. aeruginosa isolates, 84 A. baumannii isolates) obtained in the 2013-2017 from hospitalized patients in 28 public health organizations in 4 Belarus regions were included in the study.

Pseudomonas aeruginosa is recognized as one of the six most important pathogens in terms of antimicrobial resistance («ESKAPE» pathogens), and included by WHO in the group of microorganisms for which the need for development of new antimicrobial …

Pseudomonas aeruginosa is a dangerous opportunistic pathogen. One of the most negative clinically significant features of P. aeruginosa is associated with the rapid acquisition of antimicrobial resistance. This review provides an analysis of current …

Pseudomonas aeruginosa is the most abundant bacterial species causing nosocomial infections in Russia. In this paper, we report the data on antimicrobial susceptibility of 743 isolates of P. aeruginosa collected in 63 hospitals of 22 cities of Russia …

Type III Secretion System (TTSS) is a key pathogenicity factor of Pseudomonas aeruginosa. The suppression of the activity of TTSS would potentially allow block the infection independently on the presence of antimicrobial resistance. To study the role …

The activity of 11 antibiotics combinations and 4 commercially available preparations for phagotherapy in regard to metallo-beta-lactamase (MBL) producing Pseudomonas aeruginosa clinical isolates of sequence type 235 (ST 235) belonging to the clonal …

Pseudomonas aeruginosa is one of the most important pathogens causing opportunistic infections. This literature review contains analysis of articles on molecular characteristics of P. aeruginosa virulence factors, as well as the pathogenesis of …