Ceftolozane/tazobactam – the «new player» in a battle against multiresistant pathogens

Ceftolozane/tazobactam is a new combined antibacterial agent for the treatment of infections caused by gram-negative microorganisms, P. aeruginosa in particular, including strains resistant to other clinically available antimicrobials. In this paper …

Antimicrobial Resistance of Gram-negative Microorganisms Causing Complicated Intra-abdominal Infections in Russia

Objective. To assess antimicrobial resistance of gram-negative microorganisms causing complicated intra-abdominal infections (IAI) in Russia. Materials and Methods. This was a multicenter (a total of 21 cities), prospective, microbiological study to collect Gram-negative pathogens from patients with complicated IAI. Identification was performed using MALDITOF mass spectrometry. Minimal inhibitory concentrations (MICs) of antibiotics were determined by dilution method according to the current CLSI and EUCAST guidelines. Results. A total of 1908 isolates of gram-negative pathogens was obtained (357 isolates in community-acquired IAI, and 1551 isolates in nosocomial IAI).

Antimicrobial Therapy of Complicated Intra-abdominal Infections: What are the Success Determinants?

Successful outcome of complicated intra-abdominal infections (peritonitis) is determined by two key factors – surgical control of infection site and appropriate and timely antimicrobial therapy. Over the years choice of high antimicrobials for the …

Etiology and Antimicrobial Resistance of Hospital-acquired and Community-acquired Intra-Abdominal Infections in ICUs of Two Teaching Hospitals

Objective. To investigate the etiology and antimicrobial resistance patterns of aerobic bacterial pathogens in community- and hospital-acquired intra-abdominal infections (IAI) in the ICUs of two teaching hospitals in one particular city. Materials and Methods. A total of 168 patients with peritonitis (122 community-acquired, 46 nosocomial) were included in the study. Susceptibility testing was performed by agar dilution method according to CLSI recommendations. Results. Clinically significant aerobic pathogens were isolated in 61.