macrolides

This paper reviews general issues of the use of antimicrobial agents in pregnant women. Currently available data on safety of macrolides during pregnancy and lactation are considered with the focus on several indications for their therapeutic and …

Spiramycin, natural 16-membered macrolide antibiotic, was discovered in 1954. This antimicrobial agent is at least non-inferior to and has some advantages over the currently available macrolides in spectrum of activity, pharmacological properties, …

The present open-label, randomized, comparative study of efficacy of 8-week Azithromycin therapy in mildto-moderate stable asthma included 71 patients. After evaluation for C. pneumoniae infection by serologic tests, patients where randomized into 4 …

Multicenter prospective non-comparative open-label clinical study to assess clinical and microbiological efficacy and safety of josamycin (16-memebered macrolide) in adults with non-severe community-acquired pneumonia (CAP) was performed. Patients …

Clarithromycin – 14-membered macrolide antibiotic that has been used in clinical practice since 1991. This review presents up-to-date data on pharmacokinetics, pharmacodynamics, drug interactions, safety profile of clarithromycin, including its novel …

Spiramycin is classic representative of the 16-membered macrolides, which was synthesized in 1954. Nevertheless he keeps his clinical significance due to the high activity against typical causative agents of respiratory tract, skin and soft tissues …

The macrolide class of antibiotics is well established and often recommended for use in the treatment of community-acquired respiratory tract infections (RTI). The newer agents clarithromycin and azithromycin are frequently prescribed as firstor …