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levofloxacin

Safety and efficacy of nemonoxacin versus levofloxacin in the treatment of community-acquired pneumonia: results of phase III, multicenter, randomized, double-blind, active-controlled, non-inferiority trial

Objective. To evaluate the efficacy and safety of a step-down strategy from intravenous to oral nemonoxacin versus a step-down strategy from intravenous to oral levofloxacin in the treatment of patients with community-acquired pneumonia. Materials and Methods. This was a phase III randomized, controlled, double-blind, double-dummy, parallel groups (2 groups), multicenter trial to evaluate the efficacy and safety of intravenous and oral nemonoxacin at a daily dose of 500 mg versus levofloxacin (Tavanic®) at a daily dose of 500 mg in the treatment of adult patients with community-acquired pneumonia.

Antimicrobial resistance of Helicobacter pylori in Smolensk

Objective. To study the antimicrobial resistance of H. pylori to clarithromycin, amoxicillin, metronidazole, levofloxacin, tetracycline in adult patients in the Smolensk region. Materials and Methods. Overall, 573 adult patients were included in 2015-2017 and 210 – in 20092010 with positive rapid urease test at the time of gastroscopy for dyspeptic complaints. Antimicrobial susceptibility testing of H. pylori isolates to clarithromycin, amoxicillin, metronidazole, levofloxacin and tetracycline was performed by the agar dilution method.

A Novel View on Common Antibiotics: How to Properly Use Pharmacodynamic Parameters

The efficacy of antibacterial therapy is determined by multiple factors, including pharmacokinetic (PK) parameters of the antimicrobial agent. The predictive value of PK parameters has been confirmed in a number of in vivo experiments and clinical …

«Respiratory» Fluoroquinolones – the Neoclassics of Antimicrobial Chemotherapy

«Respiratory» fluoroquinolones, unlike previous generations, have higher activity against Gram-positive pathogens causing important infections in humans. Broad antimicrobial spectrum, ability to overwhelm some bacterial resistance mechanisms, absence …

Levofloxacin in the Treatment of Community-Acquired Pneumonia: 20-Year Successful Clinical Experience

According to international post-marketing trials, levofloxacin now belongs to the antimicrobial agents being in a great demand in clinical practice. One of the main indications for its use is community-acquired pneumonia (CAP). This review article is …

Comparative Clinical and Pharmacoeconomic Analysis of Different Antimicrobial Treatment Regimens in Hospitalized Patients with Community-Acquired Pneumonia

Objective. To conduct a cost-effectiveness analysis of combination of azithromycin with b-lactams (cefotaxime, ceftriaxone or amoxicillin/clavulanic acid) vs levofloxacin in hospitalized adults with community-acquired pneumonia (CAP). Materials and Methods. We performed standard search and meta-analysis of prospective clinical trials (CT) to compare clinical success rate and tolerability of regimens of antibacterial therapy (ABT) under the investigation. Direct medical costs (DC) including cost of ABT and hospital stay were calculated from the perspective of Smolensk Regional Clinical Hospital and Central Clinical Hospital of Russian Academy of Sciences.

Questionable Efficacy of Generics in the Treatment of Severe Community-Acquired Pneumonia

The retrospective analysis of treatment of patients with severe community-acquired pneumonia has been performed. It has demonstrated that the results of therapy with generic preparations of ceftriaxone and levofloxacin were inferior to original drug …

Levofloxacin Efficacy – the Success Predictors

Objective. Aim. To evaluate the comparable solubility of original levofloxacin (Tavanic, Sanofi–Aventis, France) and its generics. Materials and Methods. The resolution kinetics of the original drug and two generics was studied in different рН levels. The choice of рН levels was done according to the US pharmacopeia. Results. The original levofloxacin has shown the stable parameters important for bioavailability independently from рН level. At the same time resolution kinetics of two generic products significantly varied depending on рН.

Treatment of Hospitalized Patients with Pneumonia: Levofloxacin vs. Other Treatment Options

Translated and reprinted with permission from «Chemotherapie Journal» 2007; 16:41-8.

The main objective of this study was to compare the efficacy of levofloxacin in hospitalized patients suffering from pneumonia to other antibiotic options by …

What Generation of Fluoroquinolones should be Levofloxacin Put In?

Translated and Reprinted with permission from «Chemotherapy Journal» (Chemother J. 2005; 14:22-27)