fluoroquinolones

What Generation of Fluoroquinolones should be Levofloxacin Put In?

Translated and Reprinted with permission from «Chemotherapy Journal» (Chemother J. 2005; 14:22-27)

Rational choice of fluoroquinolones in community-acquired urinary tract infections

Urinary tract infections are one of the most prevalent community-acquired diseases. One of the crucial moments in the therapy of these infections is the usage of antibacterial drugs. This article shows the results of systematic review the goal of …

Quinolones in Childhood and Pregnancy. Is There a Rationale for Their Use?

The usage of quinolones and fluoroquinolones (FQ) in children and adolescents as well as in pregnant women is considered in this paper. Based on joint toxicity of FQ observed in immature animals this class of antimicrobial agents is officially …

Prevention of the Selection of Resistant Staphylococci in an in vitro Dynamic Model that Simulates Fluoroquinolone Pharmacokinetics

To study the hypothesis of the mutant selection window (MSW) in a pharmacodynamic context, the susceptibility of a clinical isolate of methicillin-resistant Stap. hylococcus aureus exposed to moxifloxacin (MOX), levofloxacin (LEV) and ciprofloxacin …

Moxifloxacin: the Present and the Future in the Sequential Therapy

Moxifloxacin is a new broad spectrum 8-meth-oxiquinolon with high activity against both Gram(+) and Gram(–) microorganisms as well as against anaerobes and intracellular pathogens. It is also active against microorganisms that are resistant to other …

The Anthrax

Anthrax, along with smallpox and plague, is considered one of the most potential biological warfare agents. It has been proved during the recent bioterroristic events in the USA in the fall last year. This article presents the questions of etiology, …

Moxifloxacin – the New Fluoroquinolone with Broad Spectrum of Activity

Moxifloxacin – new broad spectrum 8-methoxyquinolon with high activity against Gram(+) and Gram(-) microorganisms as well as against anaerobes and intracellular pathogens. It is also active against microorganisms that are resistant to other classes …