azithromycin

Comparison of in vitro activity of various macrolides against Helicobacter pylori

Objective. Compare the in vitro activity of clarithromycin, erythromycin, azithromycin and josamycin against the collection of H. pylori strains isolated in 2010–2017 in Smolensk. Materials and Methods. H. pylori strains were collected prospectively from biopsy specimens of the gastric mucosa. Antimicrobial susceptibility testing of H. pylori was performed by the agar dilution method. Interpretation of the results of the susceptibility determination for clarithromycin was carried out in accordance with the recommendations of EUCAST (v 8.

Comparative Efficacy of Azithromycin and Cefixime in the Treatment of Acute Infectious Invasive Diarrhea in Children

This paper describes a multicenter, randomized study to compare clinical and microbiological efficacy, and safety of azithromycin (Sumamed®, Teva) and cefixime (Suprax®, Gedeon-Richter) in the treatment of acute infectious invasive diarrhea in …

Efficacy and Safety of Azithromycin in the Treatment of Sexually Transmitted Diseases

This paper considers safety issues associated with medical therapy of sexually transmitted diseases (STDs). Data supporting safety of azithromycin as part of treatment regimens for infections due to chlamydia and mycoplasma are provided. Possible …

Comparative Clinical and Pharmacoeconomic Analysis of Different Antimicrobial Treatment Regimens in Hospitalized Patients with Community-Acquired Pneumonia

Objective. To conduct a cost-effectiveness analysis of combination of azithromycin with b-lactams (cefotaxime, ceftriaxone or amoxicillin/clavulanic acid) vs levofloxacin in hospitalized adults with community-acquired pneumonia (CAP). Materials and Methods. We performed standard search and meta-analysis of prospective clinical trials (CT) to compare clinical success rate and tolerability of regimens of antibacterial therapy (ABT) under the investigation. Direct medical costs (DC) including cost of ABT and hospital stay were calculated from the perspective of Smolensk Regional Clinical Hospital and Central Clinical Hospital of Russian Academy of Sciences.

Comparative Quality of Parenteral Formulations of Azithromycin Original and Generic Products

Introduction. Azithromycin is still one of the most frequently administered antimicrobials. In conditions of counterfeited generic drugs number steady growth in Russia, there is an obvious necessity of their pharmaceutical equivalence study. Objectives. Objective. Comparison of quantitative amount and stability of azithromycin, detection of impurities and insoluble particle contamination in original Sumamed product (Pliva, Croatia) and two generic drugs (Azithral, Alembic Ltd, India, and Azinort, Neon Laboratories Ltd, India).

Asthma associated with Chlamydophila pneumoniae-infection

The present open-label, randomized, comparative study of efficacy of 8-week Azithromycin therapy in mildto-moderate stable asthma included 71 patients. After evaluation for C. pneumoniae infection by serologic tests, patients where randomized into 4 …

New oral formulation for the Treatment of Community-Acquired Lower Respiratory Tract Infections

Azithromycin is one of the most commonly used macrolides in the treatment of respiratory tract infections. Azithromycin is a popular antimicrobial due to a number of its unique pharmacokinetic and pharmacodynamic properties. This review describes the …

Azithromycin: Current Clinical Use

Discovery and introduction into the clinical practice of macrolide antibiotics is one of the major advances in the history of antimicrobial therapy. The most prescribed macrolide is azithromycin, which is due to a number of its unique pharmacokinetic …

The Role of Newer Macrolides in the Treatment of Community-Acquired Respiratory Tract Infections: a Review of Experimental and Clinical Data

The macrolide class of antibiotics is well established and often recommended for use in the treatment of community-acquired respiratory tract infections (RTI). The newer agents clarithromycin and azithromycin are frequently prescribed as firstor …