Clinical Microbiology and Antimicrobial Chemotherapy. 2006; 8(1):18-32
Discovery and introduction into the clinical practice of macrolide antibiotics is one of the major advances in the history of antimicrobial therapy. The most prescribed macrolide is azithromycin, which is due to a number of its unique pharmacokinetic and pharmacodynamic properties. This allowed azithromycin to be one of the most commonly used macrolides in different types of infections over the last 10 years. This review describes azithromycin characteristics from the viewpoints of evidence-based medicine, clinical pharmacology, and clinical microbiology. Results of its clinical use in variety of the diseases, including pediatric infections, are presented.