Clinical Microbiology and Antimicrobial Chemotherapy. 2025; 27(2):134-139
To characterize spectrum of S. pneumoniae serotypes isolated from patients with invasive pneumococcal infection in the Russian Federation.
The serotype identification of 93 S. pneumoniae isolates obtained from blood and cerebrospinal fluid of patients with various forms of invasive pneumococcal disease was performed using whole-genome sequencing. PCV-13, PCV-15, PCV-20 and PPV-23 coverage of circulated serotypes was estimated using descriptive statistics.
The study included 93 S. pneumoniae isolates obtained from blood and cerebrospinal fluid of patients diagnosed with bacterial meningitis (n = 66, 65.6%), pneumonia (n = 19, 25.8%), bacteremia (n = 7, 7.5%), and infectious endocarditis (n = 1, 1.1%). The most frequent S. pneumoniae serotypes responsible for the development of invasive pneumococcal infections in this study were: 3 (n = 15, 16.1%), 19F (n = 6, 6.5%), 9N, 18C, and 23A (n = 5, 5.4%), 8, 14, 17F, and 20 (n = 4, 4.3%), 4, 5, 23F, and 28A (n = 3, 3.2%). Vaccine coverage analysis showed that PCV-13 covers 48.4% (CI 38.2%– 58.6%) of the identified S. pneumoniae serotypes, PCV-15 – 49.5% (CI 39.3%–59.7%), PCV-20 – 57.0% (CI 46.9%–67.1%), and PPSV-23 – 71.0% (CI 61.8%–80.2%).
The analysis of the spectrum of S. pneumoniae serotypes isolated from patients with invasive pneumococcal infections revealed a wide diversity. Serotypes included in PCV-13, which is part of the National Immunization Schedule of the Russian Federation, were identified in only 48.4% of cases.