invasive pneumococcal disease

Objective. To characterize spectrum of S. pneumoniae serotypes isolated from patients with invasive pneumococcal infection in the Russian Federation. Materials and Methods. The serotype identification of 93 S. pneumoniae isolates obtained from blood and cerebrospinal fluid of patients with various forms of invasive pneumococcal disease was performed using whole-genome sequencing. PCV-13, PCV-15, PCV-20 and PPV-23 coverage of circulated serotypes was estimated using descriptive statistics. Results. The study included 93 S.

Objective. To estimate prevalence and antimicrobial susceptibility of circulated S. pneumoniae serotypes in adult population in different regions of the Russian Federation. Materials and Methods. A total of 500 isolates of S. pneumoniae obtained from patients with invasive pneumococcal disease (IPD), community-acquired pneumonia (CAP), sinusitis/acute otitis media (AOM) and healthy carriers from 29 centers were included in the study from 01 June 2019 to 15 January 2020. Re-identification, typing using real-time PCR with 27 primer pairs and antimicrobial susceptibility testing were performed in the central laboratory by standardized methods.