Potential for the use of macrolides in the antimicrobial therapy of severe community-acquired pneumonia in adults | CMAC

Potential for the use of macrolides in the antimicrobial therapy of severe community-acquired pneumonia in adults

Clinical Microbiology and Antimicrobial Chemotherapy. 2019; 21(3):217-223

​ Sinopalnikov A.I., Rachina S.A., Zakharenkov I.A.
10.36488/cmac.2019.3.217-223
community-acquired pneumonia antibacterial therapy macrolides immunomodulatory effects
Section
Antimicrobials
Type
Review
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2019; 21(3):217-223

Abstract

This paper presents mechanism of action and antimicrobial spectrum of macrolides as well as the known acquired resistance mechanisms in the common pathogens causing community-acquired pneumonia, such as Streptococcus pneumoniae and Mycoplasma pneumoniae. Non-antimicrobial (anti-inflammatory and immunomodulatory) effects of macrolides that have been found in experimental and clinical studies are described in detail. Results of clinical studies and current practice guidelines which determine potential benefits and a role of macrolides in the antibacterial therapy of severe community-acquired pneumonia in adults are reviewed.

Alexander I. Sinopalnikov

Russian Medical Academy of Continuous Professional Education, Moscow, Russia

Svetlana A. Rachina

RUDN University, Moscow, Russia

Zakharenkov I.A.

Bryansk City Hospital #1, Bryansk, Russia

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