Pseudomonas aeruginosa in the etiology of infections in hospitalized patients | CMAC

Pseudomonas aeruginosa in the etiology of infections in hospitalized patients

Clinical Microbiology and Antimicrobial Chemotherapy. 2018; 20(4):387-392

​ Lyamin A.V., Petrovskaya E.V., Ketsko Yu.L., Nenyaykin S.S., Ismatullin D.D., Nikiforova F.I., Kondratenko O.V., Kozlov A.V., Zhestkov A.V.
10.36488/cmac.2018.4.387-392
Pseudomonas aeruginosa antimicrobial resistance infection control
Section
Personal Experience
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2018; 20(4):387-392

Objective.

To study the etiological role and antimicrobial susceptibility of Pseudomonas aeruginosa in one tertiary care hospital with analysis of the influence of antimicrobial stewardship implementation.

Materials and Methods.

In 2013 primary microbiological evaluation was performed. In 2014 antimicrobial stewardship program was implemented. The impact of the introduction of microbiological monitoring system and antimicrobial stewardship program was evaluated.

Results.

In total, 461 P. aeruginosa strains were isolated during the study period. Rates of P. aeruginosa isolation from clinical samples during 2013-2017 were: 4.8%, 2.9%, 2.8%, 2.4% and 3.5%, respectively. Rates of antimicrobial resistance in 2013 and 2017 were: ceftazidime – 67.7% and 28.7%, piperacillin/ tazobactam – 58.1% and 55.2%, meropenem – 41.9% and 39.8%, imipenem – 58.1% and 33.1%, gentamicin – 67.7% and 44.2%, ciprofloxacin – 67.7% and 49.2%. Carbapenemase production rates decreased during 2013-2017 from 48.4% to 13.3% overall in the hospital and from 68.4% to 29.2% in the ICU.

Conclusions.

Implementation of the infection control and antimicrobial stewardship leaded to decrease of the number of infections caused by P. aeruginosa in our tertiary care hospital with concomitant decrease of antimicrobial resistance rates in P. aeruginosa isolates.

Artem V. Lyamin

Samara State Medical University, Samara, Russia

Petrovskaya E.V.

Samara State Medical University, Samara, Russia

Ketsko Yu.L.

Samara State Medical University, Samara, Russia

Nenyaykin S.S.

Samara State Medical University, Samara, Russia

Ismatullin D.D.

Samara State Medical University, Samara, Russia

Nikiforova F.I.

Samara State Medical University, Samara, Russia

Kondratenko O.V.

Samara State Medical University, Samara, Russia

Kozlov A.V.

Samara State Medical University, Samara, Russia

Zhestkov A.V.

Samara State Medical University, Samara, Russia

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