Burden of resistant infections caused by S. aureus, E. coli, K. pneumoniae in Russian Federation

Clinical Microbiology and Antimicrobial Chemotherapy. 2018; 20(4):310-318

Type
Journal article

Abstract

The burden of bacterial resistance was assessed for the first time in Russia. The analysis was based on the results of bacteriological studies in multi-field hospitals provided by the St. Petersburg Medical Information and analytical Center. The number of patients with infections caused by strains of methicillin-resistant S. aureus (MRSA); K. pneumoniae, are not sensitive to 3rd generation cephalosporins and carbapenems; E. coli, are not sensitive to 3rd generation cephalosporins was calculated on the basis of the obtained data. The data are extrapolated to all multi-profile hospitals of the Russian Federation with regard to known levels of resistance. The total cost of treatment of patients with infections caused by three pathogens in multi-field hospitals in St. Petersburg for the year amounted to 250 887 292 rubles, in Russia – 12 413 309 939 rubles. The main costs are associated with antimicrobial therapy (90% in St. Petersburg, 88 – in Russia). The costs associated with additional beds, temporary disability, epidemiological control measures are 10% and 12%, respectively. Mathematical modeling has shown that these costs can increase by at least 10% due to the death of patients of working age.

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