Pharmacoepidemiology of antimicrobial agents in pregnant women: a non-interventional retrospective study

Clinical Microbiology and Antimicrobial Chemotherapy. 2017; 19(1):67-72

Journal article


The present study was conducted within the framework of Saint Petersburg’s multi-purpose programmes initiated in 2014 to restrain antimicrobial resistance. The study was observational and retrospective. The analysis included three maternity hospitals; 484 medical records of women were collected, the vast majority of them were women after childbirth (90.3%). The results showed that the antimicrobial agents were administered mainly for the prophylaxis of suspected (unclear) infections (42.9% cases). The second most frequent indication was treatment or prophylaxis of pelvic infection (35.8% of cases). Microbiological examinations were conducted only in 54% of patients. On average, each woman received 1.7 courses of antimicrobials, usually for the prophylaxis of infection (67.2%). Three antimicrobial agents were used in 90% of cases: metronidazole, cefazolin and ceftriaxone. Antimicrobial agents prescribed to pregnant women were considered safe for a long-term use in 54%, the rest of them were safe only for a short-term use. The authors provide recommendations to improve current practices.

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