Pharmacoepidemiology of antimicrobial agents in pregnant women: a non-interventional retrospective study | CMAC

Pharmacoepidemiology of antimicrobial agents in pregnant women: a non-interventional retrospective study

Clinical Microbiology and Antimicrobial Chemotherapy. 2017; 19(1):67-72

​ Kolbin A.S., Sidorenko S.V., Zagorodnikova K.A., Lobzin Yu.V., Ivanov D.O., Shabalov N.P., Mikhailov A.V., Klimko N.N., Dolgov G.V., Shmidt A.A., Galankin T.L., Kurylyov A.A., Malikova E.A.
pregnant women antimicrobial agents infectious agents
Section
Personal Experience
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2017; 19(1):67-72

Abstract

The present study was conducted within the framework of Saint Petersburg’s multi-purpose programmes initiated in 2014 to restrain antimicrobial resistance. The study was observational and retrospective. The analysis included three maternity hospitals; 484 medical records of women were collected, the vast majority of them were women after childbirth (90.3%). The results showed that the antimicrobial agents were administered mainly for the prophylaxis of suspected (unclear) infections (42.9% cases). The second most frequent indication was treatment or prophylaxis of pelvic infection (35.8% of cases). Microbiological examinations were conducted only in 54% of patients. On average, each woman received 1.7 courses of antimicrobials, usually for the prophylaxis of infection (67.2%). Three antimicrobial agents were used in 90% of cases: metronidazole, cefazolin and ceftriaxone. Antimicrobial agents prescribed to pregnant women were considered safe for a long-term use in 54%, the rest of them were safe only for a short-term use. The authors provide recommendations to improve current practices.

Alexey S. Kolbin

First Saint-Petersburg State Medical University named after I.P. Pavlov, Saint-Petersburg, Russia
Saint-Petersburg State University, Saint-Petersburg, Russia

Sergey V. Sidorenko

Research Institute of Children’s Infections, Saint-Petersburg, Russia

Ksenia A. Zagorodnikova

North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia

Yuriy V. Lobzin

Research Institute of Children’s Infections, Saint-Petersburg, Russia

Ivanov D.O.

Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russia

Shabalov N.P.

S.M. Kirov Military Medical Academy, Saint-Petersburg, Russia

Mikhailov A.V.

North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia

Nikolay N. Klimko

North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia

Dolgov G.V.

S.M. Kirov Military Medical Academy, Saint-Petersburg, Russia

Shmidt A.A.

S.M. Kirov Military Medical Academy, Saint-Petersburg, Russia

Galankin T.L.

First Saint-Petersburg State Medical University named after I.P. Pavlov, Saint-Petersburg, Russia

Kurylyov A.A.

First Saint-Petersburg State Medical University named after I.P. Pavlov, Saint-Petersburg, Russia

Malikova E.A.

First Saint-Petersburg State Medical University named after I.P. Pavlov, Saint-Petersburg, Russia

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