Vancomycin Dosing in Hemodialysis Patients | CMAC

Vancomycin Dosing in Hemodialysis Patients

Clinical Microbiology and Antimicrobial Chemotherapy. 2014; 16(2):130-136

​ Ivanov A.S.
hemodyalisis vancomycin antimicrobial therapy MRSA dosing protocol
Section
Antimicrobials
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2014; 16(2):130-136

Abstract

Infectious complications are constitute a serious challenge for patients receiving hemodialysis. With regard to the broad spread of S. aureus isolates with lost susceptibility to β-lactams (MRSA) vancomycin is key option for treatment of these infections. However, conventional dosing protocol in this patients population is not sufficiently effective at present. It does not allow to achieve necessary trough serum vancomycin concentrations and to ensure pharmacodynamic conditions for successful eradication of MRSA with MIC of vancomycin ≥1 mg/l. New dosing protocol was developed and clinically validated recently

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