Clonal dissemination of CTX-M-5-producing nosocomial strains of Salmonella Typhimurium in Russia, Belarus, and Kazakhstan | CMAC

Clonal dissemination of CTX-M-5-producing nosocomial strains of Salmonella Typhimurium in Russia, Belarus, and Kazakhstan

Clinical Microbiology and Antimicrobial Chemotherapy. 2012; 14(1):38-50

​ Kozyreva V.K., Edelstein M.V., Tapalskiy D.V., Azyzov I.S., Romanov A.V., Kozlov R.S.
Salmonella Typhimurium nosocomial infection clonal dissemination antimicrobial resistance
Section
Antimicrobial Resistance
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2012; 14(1):38-50

Abstract

In this paper, the evidence of broad geographic dissemination of Salmonella enterica serovar Typhimurium strains belonging to a single genetic lineage is presented. The isolates described possess resistance to oxiiminocephalosporines due to production of CTX-M-5 extended-spectrum b-lactamase. The genetic relatedness of the strains isolated during multiple outbreaks of nosocomial salmonellosis in various parts of Russia, Belarus and Kazakhstan was established by pulsed-field gel electrophoresis (PFGE) and multi-locus tandem repeat analysis (MLVA). Circulation of the clone was first noticed in 1994 and is currently ongoing according to the data presented. The resistance to multiple antibiotics including penicillininhibitor combinations and various non-b-lactam drugs is mediated by large conjugative plasmids, while blaCTX-M-5 gene is associated with ISEcp1 element and carried by small non-conjugative plasmid. Some isolates express resistance to nalidixic acid owing to mutations in QRDR of gyrA gene.

  • 1. Nakaya H., Yasuhara A., Yoshimura K., Oshihoi Y., Izumiya H.,Watanabe H. Life-threatening infantile diarrhea from fluoroquinolone-resistant Salmonella enterica typhimurium with mutations in both gyrA and parC. Emerg Infect Dis 2003; 9(2):255-7.
  • 2. Lan R., Reeves P.R.,Octavia S. Population structure, origins and evolution of major Salmonella enterica clones. Infect Genet Evol 2009; 9(5): 996-1005.
  • 3. Velge P., Cloeckaert A., Barrow P. Emergence of Salmonella epidemics: the problems related to Salmonella enterica serotype Enteritidis and multiple antibiotic resistance in other major serotypes. Vet Res 2005; 36(3):267-88.
  • 4. Foley S.L., Lynne A.M. Food animal-associated Salmonella challenges: pathogenicity and antimicrobial resistance. J Anim Sci 2008; 86(14 Suppl):E173-87.
  • 5. Акимкин В.Г., Покровский В.И. Нозокомиальный сальмонеллез взрослых. Издательство РАМН 2002:35-72.
  • 6. Акимкин В.Г. Нозокомиальный сальмонеллез как самостоятельная нозологическая форма инфекционной патологии человека. Журнал микробиологии, эпидемиологии и иммунобиологии 1998; (4):106-110.
  • 7. Edelstein M., Pimkin M., Dmitrachenko T., et al. Multiple outbreaks of nosocomial salmonellosis in Russia and Belarus caused by a single clone of Salmonella enterica serovar Typhimurium producing an extended-spectrum beta-lactamase. Antimicrob Agents Chemother 2004; 48(8):2808-15.
  • 8. Tapalski D., Hendriksen R.S., Hasman H., Ahrens P., Aarestrup F.M. Molecular characterisation of multidrugresistant Salmonella enterica serovar Typhimurium isolates from Gomel region, Belarus. Clin Microbiol Infect 2007; 13(10):1030-3.
  • 9. Orman B.E., Pineiro S.A., Arduino S., et al. Evolution of multiresistance in nontyphoid salmonella serovars from 1984 to 1998 in Argentina. Antimicrob Agents Chemother 2002; 46(12): 3963-70.
  • 10. Yan J.J., Ko W.C., Chiu C.H., Tsai S.H., Wu H.M., Wu J.J. Emergence of ceftriaxone-resistant Salmonella isolates and rapid spread of plasmid-encoded CMY-2- like cephalosporinase, Taiwan. Emerg Infect Dis 2003; 9(3):323-8.
  • 11. Yu F., Chen Q., Yu X., et al. High prevalence of extendedspectrum beta lactamases among Salmonella enterica Typhimurium isolates from pediatric patients with diarrhea in China. PLoS One 2011; 6(3):e16801.
  • 12. Clinical and Laboratory Standards Institute, Performance standards for antimicrobial susceptibility testing (21st informational supplement). Wayne, PA, USA; 2011
  • 13. Dionisi A.M., Graziani C., Lucarelli C., et al. Molecular characterization of multidrug-resistant strains of Salmonella enterica serotype Typhimurium and Monophasic variant (S. 4,[5],12:i:-) isolated from human infections in Italy. Foodborne Pathog Dis 2009; 6(6):711-7.
  • 14. Targant H., Ponsin C., Brunet C., et al. Characterization of resistance genes in multidrug-resistant Salmonella enterica serotype Typhimurium isolated from diseased cattle in France (2002 to 2007). Foodborne Pathog Dis 2010; 7(4):419-25.
  • 15. dos Reis E.M., Rodrigues Ddos P., de Freitas-Almeida A.C., Hofer E. Prevalence of R-type ACSSuT in strains of Salmonella serovar Typhimurium DT193 isolated from human infections in Brazil. Rev Panam Salud Publica 2011; 29(6):387-92.
  • 16. Butaye P., Michael G.B., Schwarz S., Barrett T.J., Brisabois A.,White D.G. The clonal spread of multidrugresistant non-typhi Salmonella serotypes. Microbes Infect 2006; 8(7):1891-7.
  • 17. Arlet G., Barrett T.J., Butaye P., Cloeskaert A., Mulvey M.R.> White D.G. Salmonella resistant to extendedspectrum cephalosporins: prevalence and epidemiology. Microbes Infect 2006; 8(7):1945-54.
  • 18. Rodriguez I., Barownick W., Helmuth R., et al. Extendedspectrum {beta}-lactamases and AmpC {beta}-lactamases in ceftiofur-resistant Salmonella enterica isolates from food and livestock obtained in Germany during 2003-07. J Antimicrob Chemother 2009; 64(2):301-9.
  • 19. Heisig P. High-level fluoroquinolone resistance in a Salmonella typhimurium isolate due to alterations in both gyrA and gyrB genes. J Antimicrob Chemother 1993; 32(3):367-77.
  • 20. Aarestrup F.M., Wiuff C., Molbak K., Threlfall E.J. Is it time to change fluoroquinolone breakpoints for Salmonella spp.? Antimicrob Agents Chemother 2003; 47(2):827-9.
  • 21. Cloeckaert A., Chaslus-Dancla E. Mechanisms of quinolone resistance in Salmonella. Vet Res 2001; 32(3- 4):291-300.
  • 22. Martinez-Martinez L., Eliecer Cano M., Manuel Rodriguez-Martinez J., Calvo J., Pascual A. Plasmidmediated quinolone resistance. Expert Rev Anti Infect Ther 2008; 6(5):685-711.
  • 23. Martinez-Martinez L., Pascual A., Jacoby G.A. Quinolone resistance from a transferable plasmid. Lancet 1998; 351(9105):797-9.
  • 24. Robicsek A., Strahilevitz J., Jacoby G.A., et al. Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. Nat Med 2006; 12(1):83-8.
  • 25. Lindstedt B.A., Vardund T., Aas L.,Kapperud G. Multiple-locus variable-number tandem-repeats analysis of Salmonella enterica subsp. enterica serovar Typhimurium using PCR multiplexing and multicolor capillary electrophoresis. J Microbiol Methods 2004; 59(2):163- 72.
  • 26. Tenover F.C., Arbeit R.D., Goering R.V. How to select and interpret molecular strain typing methods for epidemiological studies of bacterial infections: a review for healthcare epidemiologists. Molecular Typing Working Group of the Society for Healthcare Epidemiology of America. Infect Control Hosp Epidemiol 1997; 18(6):426- 39.
  • 27. Swaminathan B., Barrett T.J., Hunter S.B., Tauxe R.V. PulseNet: the molecular subtyping network for foodborne bacterial disease surveillance, United States. Emerg Infect Dis 2001; 7(3):382-9.
  • 28. Hopkins K.L., Peters T.M., de Pinna E., Wain J. Standardisation of multilocus variable-number tandem-repeat analysis (MLVA) for subtyping of Salmonella enterica serovar Enteritidis. Euro Surveill 2011; 16(32).
  • 29. Tamamura Y., Uchida I., Tanaka K., et al. Molecular epidemiology of Salmonella enterica serovar typhimurium isolates from cattle in hokkaido, Japan: evidence of clonal replacement and characterization of the disseminated clone. Appl Environ Microbiol 2011; 77(5): 1739-50.
  • 30. Torpdahl M., Sorensen G., Ethelberg S., Sando G., Gammelgard K., Porsbo L.J. A regional outbreak of S. Typhimurium in Denmark and identification of the source using MLVA typing. Euro Surveill 2006; 11(5):134-6.
  • 31. Bauernfeind A., Casellas J.M., Goldberg M., et al. A new plasmidic cefotaximase from patients infected with Salmonella typhimurium. Infection 1992; 20(3):158-63.
  • 32. European Committee on Antimicrobial Susceptibility Testing, Breakpoint tables for interpretation of MICs and zone diameters (v 2.0.2012-01-01). www.eucast.org.
  • 33. Nuesch-Inderbinen M.T., Kayser F.H., Hachler H. Survey and molecular genetics of SHV beta-lactamases in Enterobacteriaceae in Switzerland: two novel enzymes, SHV-11 and SHV-12. Antimicrob Agents Chemother 1997; 41(5):943-9.
  • 34. Степанова М.Н. Мутационная изменчивость CTX-M b-лактамаз и формирование устойчивости к цефтазидиму у клинических и лабораторных штаммов Escherichia coli [диссертация на соискание уч. степ. к.б.н.]. Смоленск: СГМА 1-119.
  • 35. Kholodii G., Yurieva O., Mindlin S., Gorlenko Z., Rubochkin V., Nikiforov V. Tn5044, a novel Tn3 family transposon coding for temperature-sensitive mercury resistance. Res Microbiol 2000; 151(4):291-302.
  • 36. Struelens M.J., Rost F., Deplano A., et al. Pseudomonas aeruginosa and Enterobacteriaceae bacteremia after biliary endoscopy: an outbreak investigation using DNA macrorestriction analysis. Am J Med 1993; 95(5):489-98.
  • 37. Tenover F.C., Arbeit R.D., Goering R.V., et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995; 33(9):2233-9.
  • 38. Bradford P.A., Yang Y., Sahm D., Grope I., Gardovska D., Storch G. CTX-M-5, a novel cefotaxime-hydrolyzing beta-lactamase from an outbreak of Salmonella typhimurium in Latvia. Antimicrob Agents Chemother 1998; 42(8):1980-4.
  • 39. Livermore D.M. beta-Lactamases in laboratory and clinical resistance. Clin Microbiol Rev 1995; 8(4):557-84.
  • 40. Wasyl D., Sandvang D., Skov M.N., Baggesen D.L. Epidemiological characteristics of Salmonella Typhimurium isolated from animals and feed in Poland. Epidemiol Infect 2006; 134(1):179-85.
  • 41. Акимкин В.Г. Современные клинико-эпидемические аспекты нозокомиального сальмонеллеза. Медицинский алфавит. Эпидемиология и санитария 2010; (3):4-9.
  • 42. Tassios P.T., Gazouli M., Tzelepi E., et al. Spread of a Salmonella typhimurium clone resistant to expandedspectrum cephalosporins in three European countries. J Clin Microbiol 1999; 37(11):3774-7.
  • 43. Zirnstein G.W., Swaminathan B., Angulo F., Tenover F., Rasheed J. Plasmid-Mediated CTX-M-5 b-lactamase Conferring Resistance to Ceftriaxone and Cefotaxime in a Salmonella serotype Typhimurium var. Copenhagen Isolate from an Infant Adopted from Russia. 2nd International Conference on Emerging Infectious Diseases; 2000 July; Atlanta, GA, US.
  • 44. Fabre L., Delaune A., Espie E., et al. Chromosomal integration of the extended-spectrum beta-lactamase gene blaCTX-M-15 in Salmonella enterica serotype Concord isolates from internationally adopted children. Antimicrob Agents Chemother 2009; 53(5):1808-16.
  • 45. Sun Y., Zeng Z., Chen S., Ma J., He L., Liu Y., et al. High prevalence of bla(CTX-M) extended-spectrum betalactamase genes in Escherichia coli isolates from pets and emergence of CTX-M-64 in China. Clin Microbiol Infect 2010; 16(9):1475-81.
  • 46. Mendonca N., Leitao J., Manageiro V., Ferreira E., Canica M. Spread of extended-spectrum beta-lactamase CTX-M-producing Escherichia coli clinical isolates in community and nosocomial environments in Portugal. Antimicrob Agents Chemother 2007; 51(6):1946-55.
  • 47. Hopkins K.L., Batchelor M.J., Liebana E., DeheerGraham A.P., Threlfall E.J. Characterisation of CTX-M and AmpC genes in human isolates of Escherichia coli identified between 1995 and 2003 in England and Wales. Int J Antimicrob Agents 2006; 28(3):180-92.
  • 48. Streit J.M., Jones R.N., Toleman M.A., Stratchounski L.S., Fritsche T.R. Prevalence and antimicrobial susceptibility patterns among gastroenteritis-causing pathogens recovered in Europe and Latin America and Salmonella isolates recovered from bloodstream infections in North America and Latin America: report from the SENTRY Antimicrobial Surveillance Program (2003). Int J Antimicrob Agents 2006; 27(5):367-75.
  • 49. Kay R.S., Vandevelde A.G., Fiorella P.D., et al. Outbreak of healthcare-associated infection and colonization with multidrug-resistant Salmonella enterica serovar Senftenberg in Florida. Infect Control Hosp Epidemiol 2007; 28(7):805-11.
  • 50. Olsen S.J., DeBess E.E., McGivern T.E., Marano N., Eby T., Mauvais S., et al. A nosocomial outbreak of fluoroquinolone-resistant salmonella infection. N Engl J Med 2001; 344(21):1572-9.
  • 51. Tzouvelekis L.S., Gazouli M., Markogiannakis A., Paraskaki E., Legakis N.J., Tzelepi E. Emergence of resistance to third-generation cephalosporins amongst Salmonella typhimurium isolates in Greece: report of the first three cases. J Antimicrob Chemother 1998; 42(2):273-5.
Views
0 Abstract
0 PDF
0 Crossref citations
Shared