Clinical Microbiology and Antimicrobial Chemotherapy. 2010; 12(1):23-30
Central venous access is commonly used in clinical practice for a wide spectrum of procedures, such as hemodialysis, long-term chemotherapy, parenteral nutrition, etc. The main complications limiting the duration of use of central catheters and implantable (subcutaneous) ports include microbial contamination and possible catheter-related bloodstream infections. A novel approach to prophylaxis of the complications using specific antimicrobial solution (taurolidine) as a catheter lock and its possible benefits are reviewed in this paper. Based on the level of evidence for the taurolidine studies conducted to date and our data on antimicrobial susceptibility of pathogens causing bloodstream infections, authors provide pharmacokinetic and pharmacodynamic rationale for wide use of this catheter lock approach.