Antimicrobial Prophylaxis in Colorectal Surgery | CMAC

Antimicrobial Prophylaxis in Colorectal Surgery

Clinical Microbiology and Antimicrobial Chemotherapy. 2007; 9(3):244-252

​ Golub A.V., Kozlov R.S.
antimicrobial prophylaxis colorectal surgery
Section
Diseases and Pathogens
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2007; 9(3):244-252

Abstract

Development of the surgical site infections is one the important causes of morbidity and mortality in surgical patients. Surgical site infections significantly prolong the length of hospital stay and increase the cost of hospitalization. Abdominal surgical operations that involve the incision of the wall of large intestine and rectum are the strict indication for antimicrobial prophylaxis. In this group of patients antimicrobial prophylaxis is significantly reducing the rate of surgical site infections. At the same time there are some reports on the not optimal efficacy of some prophylactic regimens in the patients undergoing abdominal surgery. So, the main aim of this article is to review the evidence based data on antimicrobial prophylaxis in colorectal surgery and to suggest the optimal prophylactic regimens for the real practice.

  • 1. Cruse P.J., Foord R. The epidemiology of wound infection. A 10-year prospective study of 62,939 wounds. Surg Clin North Am 1980; 60:27-40.
  • 2. Woods R.K., Dellinger E.P. Current guidelines for antibiotic prophylaxis of surgical wounds. Am Fam Physician 1998; 57:2731-40.
  • 3. Mangram A.J., Horan T.C., Pearson M.L. et al. Guideline for prevention of surgical site infection, 1999. Hospital Infection Control Practices Advisory Committee. Infect Control Hosp Epidemiol 1999; 20:247-80.
  • 4. Burke J.P. Infection control – a problem for patient safety. N Engl J Med 2003; 348:651-6.
  • 5. Solomkin J.S. Antibiotic resistance in postoperative infections. Crit Care Med 2001; 29(4):97-9.
  • 6. Kirkland K.B., Briggs J.P., Trivette S.L., et al. The impact of surgical-site infection in the 1990s: attributable mortality, excess length of hospitalization, and extra costs. Infect Control Hosp Epidemiol 1999; 20:725-30.
  • 7. Gorbach S.L., Condon R.E., Conte J.E., et al. Evaluation of new anti-infective drugs for surgical prophylaxis. Clin Infect Dis 1992; 15 (Suppl 1):313-38.
  • 8. Burton R.C. Postoperative wound infections in colon and rectal surgery. Br J Surg 1973; 60:363-8.
  • 9. Kaiser A.B., Herrington J.L., Jacobs J.K., et al. Cefoxitin versus erythromycin, neomycin and cefazolin in colorectal operations. Importance of the duration of the surgical procedures. Ann Surg 1983; 198:525-30.
  • 10. Clarke J.S., Condon R.E., Bartlett J.G., et al. Preoperative oral antibiotics reduce septic complications of colon operations: results of prospective, randomized, doubleblind clinical study. Ann Surg 1977; 186(3):251-9.
  • 11. Baum M.L., Anish D.S., Chalmers T.C., et al. A survey of clinical trials of antibiotic prophylaxis in colon surgery: evidence against further use of no-treatment controls. N Engl J Med 1981; 305:795-9.
  • 12. Smith R.L., Bohl J.K., McElearney S.T., et al. Wound infection after elective colorectal resections. Ann Surg 2004; 239:599-607.
  • 13. Horan T.C., Gaynes R.P., Martone W.J., et al. CDC definitions of nosocomial surgical infection: analyses to evaluate false-positive diagnoses. Infect Control Hosp Epidemiol 1995; 16(12):712-6.
  • 14. Itani K.M.F., Wilson S.E., Awad S.S., et al. Ertapenem versus cefotetan prophylaxis in elective colorectal surgery. N Engl J Med 2006; 355:2640-51.
  • 15. Brown S.M., Eremin S.R., Shlyapnikov S.A., et al. Prospective surveillance for surgical site infections in St. Petersburg, Russian federation. Infect Control Hosp Epidemiol 2007; 28:319-25.
  • 16. Беденков А.В., Базаров А.С., Страчунский Л.С. и др. Рутинная практика периоперационного назначения антибиотиков при абдоминальных операциях в России: результаты многоцентрового исследования. Клин микробиол антимикроб химиотер 2003; 5:12.
  • 17. Плешков В.Г., Голуб А.В., Москалев А.П., и др. Влияние инфекций области хирургического вмешательства на длительность госпитализации пациентов хирургических отделений многопрофильных стационаров. Альманах клинической медицины 2007; 16:158-64.
  • 18. Quality of care - what is it? N Engl J Med 1996; 335:891-4.
  • 19. Measuring quality of care. N Engl J Med 1996; 335:966-70.
  • 20. Weingarten S. Assessing and improving quality of care. In: Williams S.J., Torrens P.R., editors. Introduction to health care. Thomson Learning; 2002:373-91.
  • 21. Pronovost P.J., Nolan T., Zeger S., et al. How can clinicians measure safety and quality in acute care? Lancet 2004; 363:1061-7.
  • 22. Jencks S.F., Guerdon T., Burwen D.R., et al. Quality of medical care delivered to medicare beneficiaries. JAMA 2000; 284:1670-6.
  • 23. Политика применения антибиотиков в хирургии 2003. Клин микробиол антимикроб химиотер 2003; 5:302-17.
  • 24. American Society of Health-System Pharmacists. ASHP therapeutic guidelines on antimicrobial prophylaxis in surgery. Am J Health-Sys. Pharm 1999; 56:1839-88.
  • 25. Dellinger E.P., Gross P.A., Barrett T.L., et al. Quality standard for antimicrobial prophylaxis in surgical procedures. Clin Infect Dis 1994; 18:422-7.
  • 26. О состоянии заболеваемости внутрибольничными инфекционными болезнями и мерах по их предупреждению. Решение коллегии МЗ РФ от 26.11.2002 г. №16. Дезинфекц. дело 2003; 1:65.
  • 27. Семина Н.А., Ковалева Е.П., Акимкин В.Г. и др. Особенности эпидемиологии и эпидемиологического надзора за внутрибольничными инфекциями на современном этапе. Эпидемиология и инфекционные болезни 2006; 4:22-6.
  • 28. Pons-Busom M., Aguas-Compaired M., Delas J., EguileorPartearroyo B. Compliance with local guidelines for antibiotic prophylaxis in surgery. Infect Control Hosp Epidemiol 2004; 25:308-12.
  • 29. Gindre S., Carles M., Aknouch N., et al. Antimicrobial prophylaxis in surgical procedures: assessment of the guidelines application and validation of antibiotic prophylaxis kits. Ann Fr Anesth Reanim 2004; 23:116-23.
  • 30. Van Kasteren M.E.E., Kullberg B.J., Boer A.S., Mintjesde Groot J., Gyssens I.C. Adherence to hospital guidelines for surgical antimicrobial prophylaxis: a multicentre audit in Dutch hospitals. J Antimicrob Chemother 2003; 51:1389-96.
  • 31. Silver A., Eichorn A., Kral J. Timeliness and use of antibiotic prophylaxis in selected inpatient surgical procedures. Am J Surg 1996; 171:548-52.
  • 32. Finkelstein R., Reinhertz G., Embom A. Surveillance of the use of antibiotic prophylaxis in surgery. Isr J Med Sci 1996; 32:1093-7.
  • 33. Плешков В.Г., Голуб А.В., Москалев А.П. и др. Антибактериальная профилактика и качество ее проведения в абдоминальной хирургии. Инфекции в хирургии 2007; 2:20-7.
  • 34. Stellato T., Danziger L., Gordon N., et al. Antibiotics in elective colon surgery: a randomized trial of oral, systemic, and oral/systemic antibiotics for prophylaxis. Am Surg 1990; 56:251-4.
  • 35. Petrelli N., Contre D.C., Herrera L., et al. A prospective randomized trial of perioperative prophylactic cefamandole in elective colorectal surgery for malignancy. Dis Colon Rectum 1988; 31:427-9.
  • 36. Kling P.A., Dahlgren S., Oral prophylaxis with neomycin and erythromycin in colorectal surgery; more proof for efficacy than failure. Arch Surg 1989; 124:705-7.
  • 37. Song F., Glenny A.M. Antimicrobial prophylaxis in colorectal surgery: a systematic review of randomized controlled trials. Br J Surg 1998; 85:1232-41.
  • 38. Gyssens I.C. Preventing postoperative infections: current treatment recommendations. Drugs 1999; 57:175-85.
  • 39. Antibiotic prophylaxis in surgery. A national clinical guideline SIGN. ULR: http://www.sign.ac.uk
  • 40. Wenzel R.P. Preoperative antibiotic prophylaxis. N Engl J Med 1992; 326:337-9.
  • 41. Tonelli F, Mazzei T, Novelli A, et al. Italian Cooperative Group. Amoxicillin/clavulanic acid versus cefotaxime for antimicrobial prophylaxis in abdominal surgery: a randomized trial. J Chemother 2002; 14(4):366-72.
  • 42. Arnaud J.P., Bellissant E., Boissel P., Carlet J. et al. Single-dose amoxycillin-clavulanic acid vs. cefotetan for prophylaxis in elective colorectal surgery: a multicentre, prospective, randomized study. The PRODIGE Group. J Hosp Infect 1992; 22(A):23-32.
  • 43. Mosimann F, Cornu P, N’Ziya Z. Amoxycillin/clavulanic acid prophylaxis in elective colorectal surgery: a prospective randomized trial. Hosp Infect 1997; 37(1):55-64.
  • 44. Wilson A.P., Shrimpton S., Jaderberg M. A meta-analysis of the use of amoxycillin/clavulanic acid in surgical prophylaxis. J Hosp Infect 1992; 22(A):9-21.
  • 45. Davey P.G., Parker S.E., Crombie I.K., et al. The cost effectiveness of amoxicillin/clavulanic acid as antibacterial prophylaxis in abdominal and gynaecological surgery. Pharmacoeconomics 1995; 7(4):347-56.
  • 46. Zelenitsky S.A., Ariano R.E., Harding G.K.M., Silverman R.E. Antibiotic pharmacodinamics in surgical prophylaxis: an association between intraoperative antibiotic concentrations and efficacy. Antimicrob Agents Chemother 2002; 46:3026-30.
  • 47. Burke J. The effective period of preventive antibiotic action in experimental incision and dermal lesions. Surgery 1961; 50:161-8.
  • 48. Classen D.C., Evans R.S., Pestotnik S.L., Horn S.D., Menlove R.L., Burke J.P. The timing of prophylactic administration of antibiotics and the risk of surgicalwound infection. N Engl J Med 1992; 326:337-9.
  • 49. Голуб А.В. Показатели качества и пути улучшения антибактериальной профилактики в абдоминальной хирургии. Дисс. канд. мед. наук. Смоленск: 2006. 110 с.
  • 50. Bates T., Roberts J.V., Smith K., German K.A. A randomized trial of one versus three doses of augmentin as wound prophylaxis in at risk abdominal surgery. Postgrad Med J 1992; 68:811-6.
  • 51. Harbarth S., Samore M.H., Lichtenberg D., Carmeli Y. Prolonged antibiotic prophylaxis after cardiovascular surgery and its effect on surgical site infections and antimicrobial resistance. Circulation 2000; 101:2916-21.
  • 52. Juul P., Klaaborg K.E., Kronborg O. Single or multiple doses of metronidazole and ampicillin in elective colorectal surgery. A randomized trial. Dis Colon Rectum 1987; 30:526-8.
  • 53. Meijer W.S., Schmitz P.I. Prophylactic use of cefuroxime in biliary tract surgery: randomized controlled trial of single versus multiple dose in high-risk patients. Galant Trial Study Group. Br J Surg 1993; 80:917-21.
  • 54. Bozorgzadeh A., Pizzi W.F., Barie P.S., et al. The duration of antibiotic administration in penetrating abdominal trauma. Am J Surg 1999; 177:125-31.
  • 55. Eggimann P., Pittet D. Infection control in the ICU. Chest 2001; 120:2059-93.
  • 56. Hecker M.T., Aron D.C., Patel N.P., et al. Unnecessary use of antimicrobials in hospitalized patients: current patterns of misuse with an emphasis on the antianaerobic spectrum of activity. Arch Intern Med 2003; 163:972-8.
  • 57. Jimenez J.C., Wilson S.E. Prophylaxis of infection for elective colorectal surgery. Surg Infect 2003; 4:273-80.
  • 58. Kirton O.C., O’Neill P.A., Kestner M., Tortella B.J. Perioperative antibiotic use in high-risk penetrating hollow viscus injury: a prospective randomized, doubleblind, placebo-control trial of 24 hours versus 5 days. J Trauma 2000; 49:822-32.
  • 59. В.Д. Федоров, В.Г. Плешков, Л.С. Страчунский. Периоперационная антибиотикопрофилактика в абдоминальной хирургии. Пособие для врачей. Клин микробиол антимикроб химиотер 2004; 6:186-92.
  • 60. Gerckens L., Motyl M., Mixon L., et al. Comparative in vitro activities of ertapenem against clinical isolates of enterobacteriaceae. Proceedings of 13th ECCMID, Glasgow, UK, 2003. Abstr. #P786.
  • 61. Pelak B.A., Woods G.L., Teppler H., et al. Comparative in vitro activities of ertapenem against aerobic bacterial pathogens isolated from patient with complicated intraabdominal infections. J Chemother 2002; 14:227-33.
  • 62. Solomkin J.S., Yellin A.E., Rotstein O.D., et al. Ertapenem versus piperacillin/tazobactam in the treatment of complicated intraabdominal infections. An Surg 2003; 237:235-45.
  • 63. Yellin A.E., Hassett J.M., Fernandes A., et al. Ertapenem monotherapy versus combination therapy with ceftriaxone plus metronidasole for treatment of complicated intra-abdominal infections in adults. Int J Antimicrob Agents 2002; 20:165-73.
  • 64. Dela Pena A.S., Asperger W., Köckerling F., et al. Ertapenem versus piperacillin/tazobactam for the treatment on intra-abdominal infections requiring surgical interventions (OASIS-1): results of prospective, randomized, open-label study. Proceedings of 14th ECCMID, Prague, Czech Republic, 2004. Abstr. #P1686.
  • 65. Teppler H., Gesser R., Meibohm A., et al. Ertapenem once a day is highly effective for treatment of generalized peritonitis. Proceedings of 13th ECCMID, Glasgow, UK, 2003. Abstr. #P781.
  • 66. Mixson L., Shungu D., Motyl M., et al. Comparative in vitro activities of ertapenem against aerobic and anaerobic bacteria from Europe. Proceedings of 13th ECCMID, Glasgow, UK, 2003. Abstr. #P784.
  • 67. Citron D.M., Mixson L., Goldstein E.C.L., et al. In vitro activities of ertapenen and other agents against clinical isolates of anaerobes. Proceedings of 13th ECCMID, Glasgow, UK, 2003. Abstr. #P780.
  • 68. Paterson D.L., Rossi F., Baquero F., et al. In vitro susceptibilities of aerobic and facultative gram-negative bacilli isolates from patient with intra-abdominal infections worldwide: tre 2003 study for monitoring antimicrobial resistance trends (SMART). J Antimicrob Chemoter 2005; 55:965-73.
  • 69. Livermore D.M., Carter M.W., Bagel S., et al. In vitro activities of ertapenem (MK-0826) against recent clinical bacteria collected in Europe and Australia. Antimicrob Agents Chemother 2001; 45:1860-7.
  • 70. Borbone S., Cascone C., Santagati M., et al. Bactericidal activity of ertapenem against major intra-abdominal pathogens. Int J Antimicrob Agents 2006; 28:396-401.
  • 71. Majumdar A.K., Musson D.G., Birk K.L., et al. Pharmacokinetics of ertapenem in healthy young volunteers. Antimicrob Agents Chemother 2002; 46:3506-11.
  • 72. Wittau M., Wagner E., Kaever V., et al. Intraabdominal tissue concentration of ertapenem. J Antimicrob Chemoter 2006; 57:312-6.
  • 73. Friedland I., Mixson L.A., Majumdar A., et al. In vitro activity of ertapenem against common clinical isolates in relation to human pharmacokinetics. J Chemother 2002; 14:483-91.
  • 74. Sexton D. Carbapenems for surgical prophylaxis? N Engl J Med 2006; 355:2693-5.
  • 75. Antimicrobial prophylaxis for surgery. Treatment Guidelines from the medical. Letter 2006; 4:83-8.
  • 76. National Nosocomial Infections Surveillance (NNIS) report, data summary from October 1986-April 1996. Am J Infect Control 1996; 24: 380-8.
  • 77. DiNubile M.J., Friedland I., Chan C.Y., et al. Bowel colonization with resistant gram-negative bacilli after antimicrobial therapy of intra-abdominal infections: observations from two randomized comparative clinical trials of ertapenem therapy. Eur J Clin Microbiol Infect Dis 2005; 24:443-9.
  • 78. DiNubile M.J., Chow J.W., Satishchandran V., et al. Acquisition of resistant bowel flora during a double-blind randomized clinical trial of ertapenem versus piperacillin-tazobactam therapy for intraabdominal infections. Antimicrob Agents Chemother 2005; 49:3217-21.
  • 79. Беденков А.В. Фармакоэпидемиологическая и фармакоэкономическая оценка периоперационной антибиотикопрофилактики в абдоминальной хирургии. Автореф. дис. канд. мед. наук. Смоленск, 2003. 22 с.
  • 80. Муконин А.А. Оптимизация режимов периоперационной антибиотикопрофилактики. Автореф. дис. канд. мед. наук. Смоленск, 2000. 23 с.
  • 81. Розенсон О.Л. Фармакоэкономическая оптимизация применения антибиотиков в хирургии. Автореф. дис. канд. мед. наук. Смоленск, 2000. 22 с.
  • 82. Забросаев В.С., Зузова А.П., Антропов В.К. Антибиотикотерапия и антибиотикопрофилактика в хирургии. Методические рекомендации. Смоленск.: СГМИ; 1994. с. 14-25.
  • 83. Практическое руководство по антиинфекционной химиотерапии. Под ред. Страчунского Л.С., Белоусова Ю.Б., Козлова С.Н. М.: Боргес; 2002. с. 276-8.
  • 84. Страчунский Л.С., Козлов Р.С. Антибиотико­профилактика в хирургии: взгляд клинического фармаколога. Рациональные подходы к профилактике инфекционных осложнений в хирургии. М.: Универсум паблишинг; 1997. с. 12-21.
  • 85. Страчунский Л.С., Козлов С.Н. Современная антимикробная химиотерапия. Руководство для врачей. М.: Боргес; 2002. с. 395-404.
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