Clinical Microbiology and Antimicrobial Chemotherapy. 2006; 8(4):383-388
Invasive aspergillosis is a common complication in children with hemoblastosis. This type of mycosis characterized with severe clinical presentations and high attributive mortality. Monotherapy with one of the systemic antimycotics is often using to treat invasive aspergillosis. During last years several reports concerning efficacy of combined therapy with different antifungal agents were published. The authors analyze their own experience of treating invasive aspergillosis with caspofungin and voriconazole combination in child with hemoblastosis, and also review a literature data.