Risk Factors for Development of Candidemia in Neonates with Gestational Age Less Than 32 Weeks

Clinical Microbiology and Antimicrobial Chemotherapy. 2005; 7(1):97-102

Journal article


The presend study is a retrospective case–control study included 218 infants with gestation age less than 32 weeks hospitalised in the neonatal ICU during 1999–2002. Frequency of the candidemia was 5%. Mortality in newborns with candidemia was 91%. Statistical analysis demonstrated the following significant risk factors for candidemia, including gestation age <29 weeks, birth weight <1000 gram, use of carbapenems (p<0,05). Apgar <5, duration of the parenteral nutrition, duration of the intubation, use of steroids, theophylline, diuretics, aminoglycosides, cephalosporins, penicillins, fluoroquinolones, metronidazole, gastrointestinal tract colonization, were not independent risk factors.

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