Clinical Microbiology and Antimicrobial Chemotherapy. 2003; 5(3):259-274
The present in vitro study of antimicrobial susceptibility of nosocomial Gram,negative pathogens to cefepime and other antimicrobials has been performed by the ROSNET study group in 28 medical institutions in Russia. The most active agent against Enterobacteriaceae among cefalosporins was cefepime. The rates of non,susceptibility to cefepime in E. coli, Klebsiella spp., Enterobacter spp., Serratia spp., Proteus spp. were 4.9, 13.6, 5.1, 9.4 and 4.2%, respectively. The penicillins, including antipseudomonal and inhibitor,protected, have shown poor activity against Enterobacteriaceae. All enterobacteria strains with the exception of Providencia spp. were susceptible to imipenem. Amikacin was significantly more active than gentamicin. The most active against nosocomial P. aeruginosa were cefepime, ceftazidime and amikacin with rates of resistance 2.2, 4.3 and 5.9%, respectively. Taking into account the high activity of cefepime agains nosocomial Gram,negative bacteria it can be considered as one of drugs of choice in the treatment of nosocomial infections.