Candidemia In Hospitalized Patients In Saint-Petersburg

Clinical Microbiology and Antimicrobial Chemotherapy. 2002; 4(1):15-21

Journal article


During prospective study carried out in 1998–2000 risk factors, spectrum of pathogens, treatment options and mortality in 45 episodes of candidemia in 45 patients from 16 Saint-Petersburg’s hospitals have been analyzed. Majority (84%) of patients with candidemia were hospitalized in intensive care units (ICU), 13% – in therapeutic wards and 3% – in surgical one. The main reasons for admission in ICU were operations (36%), neoplasms (33%) and traumas (13%). Etiologic agents of candidemia were Candida parapsilosis (32%), C.albicans (28%), C.tropicalis (10%), C.glabrata (8%), С.guilliermondii (2%), C.famata (2%), C.zeylanoides (2%), C.rugosa (2%), С.krusei (2%), C.lusitaniae (2%), Candida sp. (10%). Two and more species of Candida spp. has been isolated from blood in 9% of patients. Localized lesions in different organs have been found in 38% of patients. Antifungal therapy was administered to 60% of patients; intravenous catheters were removed in 68%. Total mortality within 30 days after diagnosis of candidemia was 49%. Mortality in patients who received antifungal therapy was 37%, in patients without specific therapy – 72%. Mortality after removal of intravenous catheter was 35%, without removal – 92%.

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