Prions and prion diseases

Clinical Microbiology and Antimicrobial Chemotherapy. 2000; 2(2):12-19

Journal article


Prion diseases belong to the group of neurodegenerative diseases that are very rare in general population and are registered as sporadic, infectious and inherited forms. These diseases are caused by contagious prion protein that appears as the result of conformational changes of normal host protein on posttranslational stage. There is phenotypical heterogenesis of prion diseases is the result of interreaction of several factors. The most important of them seems to be the expression of the protein PrPres and polymorphism in codon 129. Lifetime diagnosis of prion diseases is insufficient and there is no reliable options for treatment of these disease as well as for specific prophylaxis.

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