Antimicrobials

This article describes clinical development stages for the novel anti-TB drug «Perchlozone®», which has been approved in Russian Federation in 2012. Based on the phase I–III clinical studies results, efficacy and safety of the drug were assessed, and …

Objective. Objectives. To investigate etiology and in vitro susceptibility of the most common pathogens causing community-acquired urinary tract infections (UTIs) in Russia. Materials and Methods. A total of 182 uropathogens isolated from urine samples of patients with communityacquired UTI were collected in Russia during 2013–2014 and included in the study. Results. Among the identified microorganisms the most prevalent uropathogens were Enterobacteriaceae (87,9%) and E. coli (68,1%). Drugs active against more than 90% of all Enterobacteriaceae isolates were fosfomycin (98,1%) and ceftibuten (93,1%).

Development of new antimicrobial agents is one of the main directions to combat the problem of antimicrobial resistance. The article is an overview of innovative antibiotics for systemic use that are under non-clinical and clinical development …

This article describes the factors contributing reduced efficacy of antimicrobial agents in elderly patients, as well as the factors and mechanisms compromising safety of this drug class. Specific aspects of the administration of different …

This review describes known mechanisms, possible causes of cardiac toxicity of macrolides antibiotics and the incidence of this adverse effect.

Antibacterial agents take a first place among causes of non-acetaminophen (paracetamol) associated druginduced liver injury (DILI) and fulminant liver failure in European countries and the US. The leading hepatotoxic antibiotic is …

Due to increased use of antibiotics in current clinical practice it is very important to evaluate all risks of antimicrobial therapy. Pharmacovigilance plays a vital role in ensuring that doctors, together with the patient, have enough information …

Telavancin is a first marketed representative of semisinthetic lipoglycopeptides — new generation of glycopeptide antimicrobials. Telavancin is registered for the treatment of nosocomial pneumonia and skin and soft tissue infections caused by Gram(+) …

This paper presents current issues with the oral thirdgeneration cephalosporins in outpatient clinical practice. These data are based on the principles of appropriate antimicrobial therapy, national antimicrobial susceptibility data, and …

Honey is a traditional topical treatment for infected wounds was rediscovered in recent years. There are now many published reports describing the effectiveness of honey in rapidly clearing infection from wounds, with no adverse effects. In …