Antimicrobials

This article presents data of multicenter open-label randomized clinical trial of clinical and microbiological efficacy and safety of 7- and 10-day courses of new formulation («Solutab») of josamycin in the treatment of acute streptococcal …

There are many antibiotics from various chemical classes available in drug armamentarium for the treatment of community-acquired infections at out-patient basis. In such cases safety and tolerability of administered treatment is of no less importance …

Surgical site infections (SSI) currently remain a significant medical problem due to their high incidence, severity, social consequences, and healthcare costs. An advanced approach to prevent SSI which considers surgical suture material as an implant …

Aminoglycosides is one of the main antimicrobial drug classes and continue to play a role in the treatment of several infections, although their relatively high rate of specific adverse reactions. Tobramycin is a typical antibiotic of this class …

Generic drugs account for 78 to 95% of drug products on the Russian pharmaceutical market and represent a common way of decreasing treatment cost. The main problem of generic drugs is a pharmaceutical quality and comparability between generic and …

Daptomycin is the first approved member of a cyclic lipopeptides class of antibiotics with anti-Gram(+) activity. In contrast to majority of other antimicrobials daptomycin has rapid bactericidal activity against not only rapidly growing, but also …

Collateral damage concept describes an adverse ecological effect associated with the use of antimicrobial agents. The main point is a selection of multidrug-resistant strains and subsequent colonization and infections caused by those microorganisms. …

Ciprofloxacin is the most known member of second generation quinolones, which is more active against gram-negative microorganisms and has broad antimicrobial spectrum compared to first generation quinolones. This article presents the main indications …

Beta-lactams remain one of the most commonly used antimicrobial classes in the treatment of community-acquired respiratory tract infections worldwide. Among them, cephalosporins take one of the main places because of their broad spectrum of activity …

The emergence and spread of resistance to multiple classes of antimicrobials is a growing threat, especially in microorganisms causing severe nosocomial infections in hospital settings. Tigecycline, the first in a new class of antimicrobials …