Antimicrobials

Invasive fungal infections are an actual problem of the modern medicine. This is due to the widening population of the affected patients and the increasing number of fungal strains that are resistant to the previously extensively used antifungal …

Bacterial infections in orthopedic and reconstructive surgery are associated with significant morbidity and poor functional outcomes. Surgical management (excision of infected and devascularized tissues, obliteration of dead space, restoration of …

Objective. Aim. To evaluate the comparable solubility of original levofloxacin (Tavanic, Sanofi–Aventis, France) and its generics. Materials and Methods. The resolution kinetics of the original drug and two generics was studied in different рН levels. The choice of рН levels was done according to the US pharmacopeia. Results. The original levofloxacin has shown the stable parameters important for bioavailability independently from рН level. At the same time resolution kinetics of two generic products significantly varied depending on рН.

Introduction. Azithromycin is still one of the most frequently administered antimicrobials. In conditions of counterfeited generic drugs number steady growth in Russia, there is an obvious necessity of their pharmaceutical equivalence study. Objectives. Objective. Comparison of quantitative amount and stability of azithromycin, detection of impurities and insoluble particle contamination in original Sumamed product (Pliva, Croatia) and two generic drugs (Azithral, Alembic Ltd, India, and Azinort, Neon Laboratories Ltd, India).

Infections caused by resistant microorganisms are of particular concern for both healthcare providers and public health authorities due to associated significant social and economic losses. Improper use of antimicrobial agents, selective pressure, …

Infectious complications of pancreatic cysts (PC) is one of the problem of modern medicine due to insufficient data on pharmacokinetic of majority of antimicrobials resulting to the lack of standards for antimicrobial therapy and prophylaxis of this …

This article presents data of multicenter open-label randomized clinical trial of clinical and microbiological efficacy and safety of 7- and 10-day courses of new formulation («Solutab») of josamycin in the treatment of acute streptococcal …

There are many antibiotics from various chemical classes available in drug armamentarium for the treatment of community-acquired infections at out-patient basis. In such cases safety and tolerability of administered treatment is of no less importance …

Surgical site infections (SSI) currently remain a significant medical problem due to their high incidence, severity, social consequences, and healthcare costs. An advanced approach to prevent SSI which considers surgical suture material as an implant …

Aminoglycosides is one of the main antimicrobial drug classes and continue to play a role in the treatment of several infections, although their relatively high rate of specific adverse reactions. Tobramycin is a typical antibiotic of this class …