Antimicrobials

Ceftaroline fosamil is a novel cephalosporin antibiotic that has a high activity against multiple bacterial pathogens, including important drug-resistant microorganisms. The main benefit of the ceftaroline fosamil compared to other beta-lactams is an …

«Respiratory» fluoroquinolones, unlike previous generations, have higher activity against Gram-positive pathogens causing important infections in humans. Broad antimicrobial spectrum, ability to overwhelm some bacterial resistance mechanisms, absence …

According to international post-marketing trials, levofloxacin now belongs to the antimicrobial agents being in a great demand in clinical practice. One of the main indications for its use is community-acquired pneumonia (CAP). This review article is …

Invasive candidiasis is a common infectious complication in intensive care units and hematological malignancies chemotherapy units. This study presents data from the first-in-Russia health economics review of the anidulafungin use in the treatment of …

Invasive fungal infections are an actual problem of the modern medicine. This is due to the widening population of the affected patients and the increasing number of fungal strains that are resistant to the previously extensively used antifungal …

Bacterial infections in orthopedic and reconstructive surgery are associated with significant morbidity and poor functional outcomes. Surgical management (excision of infected and devascularized tissues, obliteration of dead space, restoration of …

Objective. Aim. To evaluate the comparable solubility of original levofloxacin (Tavanic, Sanofi–Aventis, France) and its generics. Materials and Methods. The resolution kinetics of the original drug and two generics was studied in different рН levels. The choice of рН levels was done according to the US pharmacopeia. Results. The original levofloxacin has shown the stable parameters important for bioavailability independently from рН level. At the same time resolution kinetics of two generic products significantly varied depending on рН.

Introduction. Azithromycin is still one of the most frequently administered antimicrobials. In conditions of counterfeited generic drugs number steady growth in Russia, there is an obvious necessity of their pharmaceutical equivalence study. Objectives. Objective. Comparison of quantitative amount and stability of azithromycin, detection of impurities and insoluble particle contamination in original Sumamed product (Pliva, Croatia) and two generic drugs (Azithral, Alembic Ltd, India, and Azinort, Neon Laboratories Ltd, India).

Infections caused by resistant microorganisms are of particular concern for both healthcare providers and public health authorities due to associated significant social and economic losses. Improper use of antimicrobial agents, selective pressure, …

Infectious complications of pancreatic cysts (PC) is one of the problem of modern medicine due to insufficient data on pharmacokinetic of majority of antimicrobials resulting to the lack of standards for antimicrobial therapy and prophylaxis of this …