Antimicrobials

Minimal inhibitory concentrations (MIC) was used to describe the activity of 8 systemic antimicrobials and antiseptic hexetidine against clinical strains of Streptococcus pyogenes. All tested agents showed high activity against Group A streptococci, …

This paper describes a multicenter, randomized study to compare clinical and microbiological efficacy, and safety of azithromycin (Sumamed®, Teva) and cefixime (Suprax®, Gedeon-Richter) in the treatment of acute infectious invasive diarrhea in …

Infectious complications are constitute a serious challenge for patients receiving hemodialysis. With regard to the broad spread of S. aureus isolates with lost susceptibility to β-lactams (MRSA) vancomycin is key option for treatment of these …

Cefditoren is a 3rd generation, broad-spectrum oral cephalosporin recently approved for the treatment of acute sinusitis, streptococcal pharyngitis/tonsillitis, bacterial exacerbation of chronic bronchitis, community-acquired pneumonia, and …

The changes in carbapenem consumption during 6 consecutive years have been studied in retrospective trial. 88% of carbapenems have been administered in the ICU’s and hematology department. The 3-fold increase of the total consumption during …

Infections caused by drug resistant pathogens are ever-increasing problem in hospital and outpatient settings. Nosocomial infections are associated with treatment failures, prolonged length of hospital stay and increased mortality. Chlorhexidine …

Bacteriological and clinical data on the novel cephalosporin antibiotic ceftarolin fosamil is reviewed. Ceftarolin may be considered as promising drug in Russia due to potent anti-MRSA and antipneumococcal activity, broad spectrum and low toxicity.

Objective. To assess clinical efficacy and safety of topical combination of bacitracin and neomycin in comparison to topical chloramphenicol in the treatment of uncomplicated mild to moderate surgical skin and soft tissue infections (SSTI) in adult out-patients. Materials and Methods. A total of 309 adult patients with mild to moderate SSSTI were randomized to receive either topical powder and/or ointment of bacitracin+neomycin (n=156) or topical 0.75% chloramphenicol ointment (n=153) BID.

Ceftaroline fosamil is a novel cephalosporin antibiotic that has a high activity against multiple bacterial pathogens, including important drug-resistant microorganisms. The main benefit of the ceftaroline fosamil compared to other beta-lactams is an …

«Respiratory» fluoroquinolones, unlike previous generations, have higher activity against Gram-positive pathogens causing important infections in humans. Broad antimicrobial spectrum, ability to overwhelm some bacterial resistance mechanisms, absence …