Abstract
Minimal inhibitory concentrations (MIC) was used to describe the activity of 8 systemic antimicrobials and antiseptic hexetidine against clinical strains of Streptococcus pyogenes. All tested agents showed high activity against Group A streptococci, except tetracycline and chloramphenicol. Time-killing curves showed stable bactericidal effect of hexetidine against strains with both low (4 mg /l) and high (16 mg /l) MICs.
-
1.
Kapić E., Becić F. Hexetidine - an oral antiseptic. Med Arh 2002; 56(1):43-8.
-
2.
Pilloni A.P., Buttini G., Giannarelli D., et al. Antimicrobial action of Nitens mouthwash (cetyltrimethylammonium naproxenate) on multiple isolates of pharyngeal microbes: a controlled study against chlorhexidine, benzydamine, hexetidine, amoxicillin, amoxicillin-clavulanate, clarithromycin, and cefaclor. Chemotherapy 2002; 48(4):168- 73.
-
3.
NCCLS. (1999). National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial susceptibility testing (6th ed.). Methods for Determining Bactericidal Activity of Antimicrobial Agents. Approved Standards. M26-A.
-
4.
National Committee for Clinical Laboratory Standards. (2000). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically. – Fifth Edition Approved Standard M7-A5 NCCLS, Wayne, PA.