Antimicrobial Resistance

Objective. Objectives. To analyze etiology and antimicrobial resistance of pathogens causing complicated community-acquired urinary tract infections (cUTI) in adult patients in different regions of Russia. Materials and Methods. Uropathogens isolated from urine samples of patients of both gender older than 18 years of age with community-acquired UTI were collected in 21 centers of 17 cities in Russia during 2010–2011 and included in the «DARMIS» study. Results. Among the collected 518 strains isolated from adult patients 282 strains (54,4%) were isolated from urine of patients with cUTI.

Antimicrobial susceptibility testing is an important and one of the most time-consuming and expensive procedures in microbiological laboratory. Use of appropriate panel of antibiotics along with correct identification of isolated pathogen make it …

Objective. To determine the most effective antibiotics for therapy of infectious complications of prosthetic joint implantation caused by S. aureus and S. epidermidis. Materials and Methods. The antibiotic resistance profiles were determined for 535 clinical S. aureus and 211 S. epidermidis isolates. All the strains were isolated from the removed prosthesis and biological samples from patients with prosthetic joint infection (PJI). Susceptibility of clinical isolates was determined to 14 antibiotics according to EUCAST guidelines.

Objective. To determine bacterial pathogens causing ocular infections and their antimicrobial susceptibility patterns. Materials and Methods. This prospective microbiological study included a total of 235 isolates of aerobic microorganisms obtained from 235 patients in 10 Russian regions. Susceptibility to the following antimicrobials (ampicillin, amoxicillin, amoxicillin/clavulanate, oxacillin, penicillin, ciprofloxacin, levofloxacin, moxifloxacin, ofloxacin, norfloxacin, tobramycin, gentamicin, chloramphenicol, polymyxin B, tetracycline, and erythromycin) was determined using serial dilution method. Results. The most predominant pathogens in ocular infections were S.

Objective. Objectives. To study incidence and changes of fluoroquinolone resistance among Mycobacterium tuberculosis in Novosibirsk region, and to determine fluoroquinolone contribution to drug resistance selection in M. tuberculosis population. Materials and Methods. A total of 344 clinical isolates of M. tuberculosis obtained from patients with newly diagnosed tuberculosis during the periods of 2000–2002 and 2006–2010 were tested for susceptibility to fluoroquinolones. This study included 141 isolates susceptible to first-line drugs and 83 isolates resistant to isoniazid and rifampicin (multi-drug resistance [MDR]), and 120 isolates resistant to one or more anti-TB drugs, but without MDR.

Objective. Objectives. To evaluate the level, structure and phenotypes of antimicrobial resistance in clinical respiratory strains of Streptococcus pyogenes in different regions of Russia during 1999–2009. Materials and Methods. In total 804 respiratory strains of S. pyogenes from different regions of Russia were included in the study. Susceptibility to 18 antimicrobials was evaluated by the standard broth microdilution method according to EUCAST 2012 recommendations. Results. β-Lactams remaine highly active against all tested strains.

At the present article we evaluate a relatively new method of the evaluation of activity of antimicrobials against bacterial biofilms. This method combines the possibilities of simultaneous evaluation of bacterial survival in biofilm in the presence …

Objective. Objectives. To investigate etiology and susceptibility of pathogens causing community-acquired urinary tract infections (UTIs) in different regions of Russia in various patients’ subsets to the most clinically used antimicrobials. Materials and Methods. A total of 903 uropathogens isolated from urine samples of children and adults of all age groups with acute (and recurrence of chronic) community-acquired UTIs, including pregnant women with asymptomatic bacteriuria were collected in 26 centers of 18 cities in Russia during 2010–2011 and included in the «DARMIS» study.

Currently, there is an ever-increasing consumption of probiotics contained in foods, food supplements, and medicinal products. A number of studies to determine efficacy of those products in different medical conditions is also increasing. Meanwhile, …

Here we report on a high incidence of quinolone resistance (43,1%) among nosocomial CTX-M-5 ESBLproducing S. Typhimurium isolates belonging to a single clonal group isolated in Russia, Belarus, and Kazakhstan. The resistance mechanism in all cases …