Antimicrobial Resistance

Acquired bacterial resistance is one of the leading causes of morbidity and mortality attributed to infectious diseases. Simulations may provide opportunity to predict further spread of resistance and, to some extent, manage it. The objective of this …

Carbapenem-resistant nosocomial K. pneumoniae isolates are a significant problem in clinical practice. Carbapenem resistance in K. pneumoniae isolated from hospitalized patients was 2.8% over the study period. NDM-1 carbapenemase-producing strains …

This study was aimed to determine isolation rate of H. pylori from gastric mucosal biopsies in 869 patients with chronic gastritis and gastric peptic ulcers in Republic of Tatarstan during the 2008–2013. A total of 45.5% of gastric biopsy samples …

The resistance of the systemic Candida infections causative agents is a cornerstone of the selection of an effective therapy. But if before the problem was limited to resistance to azole antifungals, then by now we have enough data about cases of …

Objective. To assess antimicrobial resistance of gram-negative microorganisms causing complicated intra-abdominal infections (IAI) in Russia. Materials and Methods. This was a multicenter (a total of 21 cities), prospective, microbiological study to collect Gram-negative pathogens from patients with complicated IAI. Identification was performed using MALDITOF mass spectrometry. Minimal inhibitory concentrations (MICs) of antibiotics were determined by dilution method according to the current CLSI and EUCAST guidelines. Results. A total of 1908 isolates of gram-negative pathogens was obtained (357 isolates in community-acquired IAI, and 1551 isolates in nosocomial IAI).

Background. Ceftaroline is a new broad-spectrum cephalosporin with in vitro activity against Gram-positive pathogens, including MRSA, and common Gram-negative pathogens. It is approved for the treatment of acute complicated bacterial skin and skin-structure infections (SSSIs) and community-acquired bacterial pneumonia. Objective. To determine in vitro activity of ceftaroline and other clinically available antimicrobials against major bacterial pathogens from different regions of Russian Federation. Materials and Methods. A total of 2778 consecutive, non-duplicate isolates were collected during multicentre microbiological in vitro study from 36 geographically distinct cities of Russia during 2008–2012.

This paper presents the study results of the representation relative level and drug resistance genes composition of intestinal microbiota in COPD patients with subsequent evaluation of the antibiotic therapy courses frequency effect on the risk of …

One of the main mechanisms of resistance of Gramnegative microorganisms to antibiotics is enzymatic hydrolysis by beta-lactamases (for example, metallobeta-lactamases). Searching of paths of strengthening of carbapenems action is possible due to …

Until now, mutational resistance to fluoroquinolones (FQs) that represent a second-line treatment option for chlamydial infections after macrolides and tetrxacyclines has not been described in clinical isolates of C. trachomatis. However, a …

In total 284 clinical nosocomial S. aureus strains isolated in 2011–2012 from patients hospitalized in 25 hospitals in 18 Russian cities were included in the study. Susceptibility to 19 antimicrobials was assessed by serial dilution method in …