Инфекции, вызванные гипервирулентными изолятами Klebsiella pneumoniae: актуальность проблемы | КМАХ

Инфекции, вызванные гипервирулентными изолятами Klebsiella pneumoniae: актуальность проблемы

Клиническая микробиология и антимикробная химиотерапия. 2025; 27(3):289-303

​ Ларин Е.С., Рачина С.А., Федина Л.В., Зайналабидова Х.Г., Агеевец В.А., Сидоренко С.В., Авдеева А.А.
10.36488/cmac.2025.3.289-303
Klebsiella pneumoniae гипервирулентность антибиотикорезистентность плазмиды вирулентности
Раздел
Болезни и возбудители
Тип
Обзор
Публикация
Клиническая микробиология и антимикробная химиотерапия. 2025; 27(3):289-303

Аннотация

Klebsiella pneumoniae относятся к одним из частых возбудителей внебольничных и нозокомиальных инфекций у госпитализированных пациентов. Среди двух известных патотипов все большее внимание привлекает гипервирулентный (hvKp), т.к. такие изоляты могут вызывать необычные по локализации и течению инфекции у ранее здоровых лиц. В настоящее время инфекции, вызванные hvKp выявляются повсеместно. Наибольшую угрозу для здравоохранения представляет конвергенция у K. pneumoniae гипервирулентности и множественной резистентности к антибиотикам. В данном обзоре представлены эпидемиологические данные по распространенности hvKp, дается характеристика гипервирулентного патотипа в сравнении с классическим с точки зрения экспрессии факторов патогенности, клинических проявлений. Обсуждаются современные подходы к диагностике инфекций, вызванных hvKp, особенности и перспективные направления терапии, возможности специфической профилактики.

Ларин Е.С.

ГБУЗ «Госпиталь для ветеранов войн № 3 Департамента здравоохранения города Москвы», Москва, Россия

Рачина Светлана Александровна

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России, Москва, Россия

Федина Л.В.

ГБУЗ «Городская клиническая больница им. С.С. Юдина Департамента здравоохранения города Москвы», Москва, Россия

Хадижат Гасановна Зайналабидова

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России, Москва, Россия

Владимир Андреевич Агеевец

ФГБУ «Детский научно-клинический центр инфекционных болезней» ФМБА России, Санкт-Петербург, Россия

Сидоренко Сергей Владимирович

ФГБУ «Детский научно-клинический центр инфекционных болезней» ФМБА России, Санкт-Петербург, Россия

Авдеева А.А.

ФГБУ «Детский научно-клинический центр инфекционных болезней» ФМБА России, Санкт-Петербург, Россия

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