Аннотация
Данный обзор литературы посвящен описанию микробиологических, патогенетических и резистентных характеристик Achromobacter spp. Являясь типичными оппортунистическими патогенами, ахромобактерии могут вызывать тяжелые и даже фатальные инфекции. Авторы акцентируют внимание на критическом анализе современных знаний о молекулярных основах клинически важных свойств ахромобактерий. Представления о факторах патогенности ахромобактерий во многом являются предсказательными, валидизация вирулентного потенциала многих факторов не подтверждалась в условиях классических экспериментов in vitro и in vivo. Ахромобактерии обладают широким спектром природной устойчивости к антибиотикам и быстро приобретают адаптивную резистентность к ним. При этом перечень антибиотиков, в отношении которых возможна интерпретация чувствительности для ахромобактерий, ограничивается лишь меропенемом, пиперациллином/тазобактамом и триметопримом/сульфаметоксазолом. Главный практический вывод заключается в том, что существует острая необходимость в разработке доступных и качественных методов быстрой видовой идентификации Achromobacter spp.
ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия
ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия
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