Почему *Klebsiella pneumoniae* становится лидирующим оппортунистическим патогеном

Игорь Викторович Чеботарь; Ю.А.  Бочарова; И.В.  Подопригора; Д.А.  Шагин

doi:10.36488/cmac.2020.1.4-19

Почему Klebsiella pneumoniae становится лидирующим оппортунистическим патогеном

Клиническая микробиология и антимикробная химиотерапия. 2020; 22(1):4-19

Чеботарь И.В., Бочарова Ю.А., Подопригора И.В., Шагин Д.А.

10.36488/cmac.2020.1.4-19

клебсиеллы Klebsiella pneumoniae вирулентность антибиотикорезистентность

Раздел

Болезни и возбудители

Тип

Обзор

Публикация

Клиническая микробиология и антимикробная химиотерапия. 2020; 22(1):4-19

Аннотация Авторы Литература PDF Статистика Репринты

Аннотация

В настоящем обзоре рассматриваются причины, которые привели к тому, что Klebsiella pneumoniae становится самым опасным оппортунистическим патогеном для человека. Кратко описаны история открытия K. pneumoniae и ее микробиологические свойства. Перечислены формы патологии, которые может вызывать K. pneumoniae. Детально проанализированы молекулярно-генетические основы вирулентности и антибиотикорезистентности K. pneumoniae. Сделан вывод о том, что главной причиной опасности клебсиелл является их способность формировать устойчивость к представителям всех классов антибиотиков.

Чеботарь Игорь Викторович

nizarnn@yandex.ru

ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия

Бочарова Ю.А.

Подопригора И.В.

ФГАОУ ВО «Российский университет дружбы народов», Москва, Россия

Шагин Д.А.

ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия
ФБУН «ЦНИИ эпидемиологии» Роспотребнадзора, Москва, Россия

1. Boucher H.W., Talbot G.H., Bradley J.S., Edwards J.E., Gilbert D., Rice L.B., et al. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis. 2009;48:1-12. DOI: 10.1086/595011
2. World Health Organization. Global Priority List of AntibioticResistance Bacteria to Guide Research, Discovery, and Development of New Antibiotics. Geneva: World Health Organization, 2017. Available at: http://apps.who.int/medicinedocs/en/m/abstract/Js23171en/. Accessed August 2019.
3. Magill S.S., Edwards J.R., Bamberg W., Beldavs Z.G., Dumyati G., Kainer M.A., et al. Multistate point prevalence survey of health care-associated infections. N Engl J Med. 2014;370:11981208. DOI: 10.1056/NEJMoa1306801
4. Cubero M., Grau I., Tubau F., Pallares R., Dominguez M.A., Linares, J., et al. Molecular epidemiology of Klebsiella pneumoniae strains causing bloodstream infections in adults. Microb Drug Resist. 2018;24(7):949-957. DOI: 10.1089/mdr.2017.0107
5. Martin R.M., Bachman M.A. Colonization, infection, and the accessory genome of Klebsiella pneumoniae. Front Cell Infect Microbiol. 2018;8:4. DOI: 10.3389/fcimb.2018.00004
6. Friedlaender C. Ueber die Schizomyceten bei der acuten fibrösen Pneumonie. Archiv F Pathol Anat. 1882;87:319-324. DOI: 10.1007/BF01880516
7. von Frisch A. Zur Atiologie des Rhinoskleroms. Wien Med Wochenschr. 1882;32:969-972.
8. Abel R. Bakteriologische Studien uber Ozaena simplex. Zentralbl Bakteriol Parazitenk Infektionskr Hyg Abt I Orig. 1893;13:161173.
9. Etiology of ozena. [No authors listed] Cal State J Med. 1916;14(8):308-309.
10. Krieg N.R., Holt J.G. Bergey’s manual of Systematic Bacteriology. Baltimore-London: Williams & Wilkins; 1984. Volume 1, 461465 pp.
11. Brill W.J. Biochemical genetics of nitrogen fixation. Microbiol Rev. 1980;44(3):449-467.
12. Orskov I., Orskov F. Serotyping of Klebsiella. In: Methods in Microbiology; 1984. Volume 14, 143-164 pp.
13. Hansen D.S., Mestre F., Alberti S., Hernandez-Alles S., Alvarez D., Domenech-Sanchez A., et al. Klebsiella pneumoniae lipopolysaccharide O typing: revision of prototype strains and O-group distribution among clinical isolates from different sources and countries. J Clin Microbiol. 1999;37(1):56-62. PMID: 9854064
14. Labrie S., Samson J., Moineau S. Bacteriophage resistance mechanisms. Nat Rev Microbiol. 2010;8:317-327. DOI: 10.1038/nrmicro2315
15. Davis T.J., Matsen J.M. Prevalence and characteristics of Klebsiella species: relation to association with a hospital environment. J Infect Dis. 1974;130:402-405. DOI: 10.1093/infdis/130.4.402
16. Podschun R., Ullmann U. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev. 1998;11(4):589-603. PMID: 9767057
17. Bagley S.T. Habitat association of Klebsiella species. Infect Control. 1985;6:52-58. DOI: 10.1017/S0195941700062603
18. Podschun R., Pietsch S., Höller C., Ullmann U. Incidence of Klebsiella species in surface waters and their expression of virulence factors. Appl Environ Microbiol. 2001;67:3325-3327. DOI: 10.1128/AEM.67.7.3325-3327.2001
19. Podschun R. Phenotypic properties of Klebsiella pneumoniae and K. oxytoca isolated from different sources. Zentralbl Hyg Umweltmed. 1990;189(6):527-535. PMID: 2200423
20. Salzman T.C., Clark J.J., Klemm L. Hand contamination of personnel as a mechanism of cross-infection in nosocomial infections with antibiotic-resistant Escherichia coli and KlebsiellaAerobacter. Antimicrob Agents Chemother. 1967;(7):97-100. PMID: 4876096
21. Jarvis W.R., Munn V.P., Highsmith A.K., Culver D.H., Hughes J.M. The epidemiology of nosocomial infections caused by Klebsiella pneumoniae. Infect Control. 1985;6:68-74. DOI: 10.1017/S0195941700062639
22. Casewell M., Phillips I. Hands as route of transmission for Klebsiella species. Br Med J. 1977;2:1315-1317. DOI: 10.1136/bmj.2.6098.1315
23. Bodena D., Teklemariam Z., Balakrishnan S., Tesfa T. Bacterial contamination of mobile phones of health professionals in Eastern Ethiopia: antimicrobial susceptibility and associated factors. Trop Med Health. 2019;47:15. DOI: 10.1186/s41182-019-0144-y
24. Gupta A., Della-Latta P., Todd B., San Gabriel P., Haas, J., Wu F., et al. Outbreak of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit linked to artificial nails. Infect Control Hosp Epidemiol. 2004;25(3):210215. DOI: 10.1086/502380
25. Lazarus B., Paterson D.L., Mollinger J.L., Rogers B.A. Do human extraintestinal Escherichia coli infections resistant to expandedspectrum cephalosporins originate from food-producing animals? A systematic review. Clin Infect Dis. 2015;60:439-452. DOI: 10.1093/cid/ciu785
26. Xu L., Sun X., Ma X. Systematic review and meta-analysis of mortality of patients infected with carbapenem-resistant Klebsiella pneumoniae. Ann Clin Microbiol Antimicrob. 2017;16(1):18. DOI: 10.1186/s12941-017-0191-3
27. Doebbeling B.N. Epidemics: identification and management. In: Prevention and control of nosocomial infections. 2nd Ed. The Williams & Wilkins Co., Baltimore, Md; 1993. 177-206 pp.
28. Ulrich N., Gastmeier P., Vonberg R.P. Effectiveness of healthcare worker screening in hospital outbreaks with gram-negative pathogens: a systematic review. Antimicrob Resist Infect Control. 2018;7:36. DOI: 10.1186/s13756-018-0330-4
29. Lery L.M., Frangeul L., Tomas A., Passet V., Almeida A.S., BialekDavenet S., et al. Comparative analysis of Klebsiella pneumoniae genomes identifies a phospholipase D family protein as a novel virulence factor. BMC Biol. 2014;12:41. DOI: 10.1186/17417007-12-41
30. Cortes G., de Astorza B., Benedi V.J., Alberti S. Role of the htrA gene in Klebsiella pneumoniae virulence. Infect Immun. 2002;70(9):4772-4776. DOI: 10.1128/iai.70.9.47724776.2002
31. Zamze S., Martinez-Pomares L., Jones H., Taylor P.R., Stillion R.J., Gordon S., et al. Recognition of bacterial capsular polysaccharides and lipopolysaccharides by the macrophage mannose receptor. J Biol Chem. 2002;277(44):41613-41623. DOI: 10.1074/jbc.M207057200
32. Arakawa Y., Wacharotayankun R., Nagatsuka T., Ito H., Kato N., Ohta M. Genomic organization of the Klebsiella pneumoniae cps region responsible for serotype K2 capsular polysaccharide synthesis in the virulent strain Chedid. J Bacteriol. 1995;177(7):1788-1796. DOI: 10.1128/jb.177.7.17881796.1995
33. Bushell S.R., Mainprize I.L., Wear M.A., Lou H., Whitfield C., Naismith J.H. Wzi is an outer membrane lectin that underpins group 1 capsule assembly in Escherichia coli. Structure. 2013;21(5):844-853. DOI: 10.1016/j.str.2013.03.010
34. Brisse S., Passet V., Haugaard A.B., Babosan A., KassisChikhani N., Struve C., et al. wzi gene sequencing, a rapid method for determination of capsular type for Klebsiella strains. J Clin Microbiol. 2013;51:4073-4078. DOI: 10.1128/JCM.01924-13
35. Yu V.L., Hansen D.S., Ko W.C., Sagnimeni A., Klugman K.P., von Gottberg A., et al. Virulence characteristics of Klebsiella and clinical manifestations of K. pneumoniae bloodstream infections. Emerg Infect Dis. 2007;13(7):986-993. DOI: 10.3201/eid1307.070187
36. Swartz E.P., Rohde P.A. Klebsiella (Friedländer’s Bacillus) infections in an army hospital. Am J Clin Pathol. 1946;16(2):8897. DOI: 10.1093/ajcp/16.2.88
37. Hsu C.R., Lin T.L., Chen Y.C., Chou H.C., Wang J.T. The role of Klebsiella pneumoniae rmpA in capsular polysaccharide synthesis and virulence revisited. Microbiology. 2011;157:3446-3457. DOI: 10.1099/mic.0.050336-0
38. Wacharotayankun R., Arakawa Y., Ohta M., Tanaka K., Akashi T., Mori M., et al. Enhancement of extracapsular polysaccharide synthesis in Klebsiella pneumoniae by RmpA2, which shows homology to NtrC and FixJ. Infect Immun. 1993;61:3164-3174. PMID: 8335346
39. Su K., Zhou X., Luo M., Xu X., Liu P., Li X., et al. Genome-wide identification of genes regulated by RcsA, RcsB, and RcsAB phosphorelay regulators in Klebsiella pneumoniae NTUH-K2044. Microb Pathog. 2018;123:36-41. DOI: 10.1016/j.micpath.2018.06.036
40. Fang C.T., Lai S.Y., Yi W.C., Hsueh P.R., Liu K.L. The function of wzy_K1 (magA), the serotype K1 polymerase gene in Klebsiella pneumoniae cps gene cluster. J Infect Dis. 2010;201:12681269. DOI: 10.1086/652183
41. Guo X.P., Sun Y.C. New insights into the non-orthodox two component Rcs phosphorelay system. Front Microbiol. 2017;8:2014. DOI: 10.3389/fmicb.2017.02014
42. Yu W.L., Ko W.C., Cheng K.C., Lee C.C., Lai C.C., Chuang Y.C. Comparison of prevalence of virulence factors for Klebsiella pneumoniae liver abscesses between isolates with capsular K1/K2 and non-K1/K2 serotypes. Diagn Microbiol Infect Dis. 2008;62(1):1-6. DOI: 10.1016/j.diagmicrobio.2008.04.007
43. Regueiro V., Campos M.A., Pons J., Alberti S., Bengoechea J.A. The uptake of a Klebsiella pneumoniae capsule polysaccharide mutant triggers an inflammatory response by human airway epithelial cells. Microbiology. 2006;152:555-566. DOI: 10.1099/mic.0.28285-0
44. Merino S., Camprubi S., Alberti S., Benedi V.J., Tomas J.M. Mechanisms of Klebsiella pneumoniae resistance to complementmediated killing. Infect Immun. 1992;60(6):2529-2535. PMID: 1587619
45. Alvarez D., Merino S., Tomas J.M., Benedi V.J., Alberti S. Capsular polysaccharide is a major complement resistance factor in lipopolysaccharide O side chain-deficient Klebsiella pneumoniae clinical isolates. Infect Immun. 2000;68(2):953955. DOI: 10.1128/iai.68.2.953-955.2000
46. Kabha K., Schmegner J., Keisari Y., Parolis H., SchlepperSchaeffer J., Ofek I. SP-A enhances phagocytosis of Klebsiella by interaction with capsular polysaccharides and alveolar macrophages. Am J Physiol. 1997;272(2):L344-L352. DOI: 10.1152/ajplung.1997.272.2.L344
47. Ofek I., Mesika A., Kalina M., Keisari Y., Podschun R., Sahly H., et al. Surfactant protein D enhances phagocytosis and killing of unencapsulated phase variants of Klebsiella pneumoniae. Infect Immun. 2001;69(1):24-33. DOI: 10.1128/IAI.69.1.2433.2001
48. Campos M.C., Vargas M.A., Regueiro V., Llompart C.M., Alberti S., Bengoechea J.A. Capsule polysaccharide mediates bacterial resistance to antimicrobial peptides. Infect Immun. 2004;72(12):7107-7114. DOI: 10.1128/IAI.72.12.71077114.2004
49. Domenico P., Tomas J.M., Merino S., Rubires X., Cunha B.A. Surface antigen exposure by bismuth dimercaprol suppression of Klebsiella pneumoniae capsular polysaccharide. Infect Immun. 1999;67(2):664-669. PMID: 9916074
50. Doorduijn D.J., Rooijakkers S.H., van Schaik W., Bardoel B.W. Complement resistance mechanisms of Klebsiella pneumoniae. Immunobiology. 2016;221(10):1102-1109. DOI: 10.1016/j.imbio.2016.06.014
51. Sahly H., Keisari Y., Ofek I. Manno(rhamno)biose-containing capsular polysaccharides of Klebsiella pneumoniae enhance opsono-stimulation of human polymorphonuclear leukocytes. J Innate Immun. 2009;1(2):136-144. DOI: 10.1159/000154812
52. Mamat U., Skurnik M., Bengoechea J.A. Lipopolysaccharide core oligosaccharide biosynthesis and assembly. In: Knirel Y., Valvano M. (Eds.) Bacterial Lipopolysaccharides. Springer; 2011. Chapter 1, 237-273 pp.
53. Raetz C.R., Guan Z., Ingram B.O., Six D.A., Song F., Wang X., et al. Discovery of new biosynthetic pathways: the lipid A story. J Lipid Res. 2009;50:S103-S108. DOI: 10.1194/jlr.R800060JLR200
54. Follador R., Heinz E., Wyres K.L., Ellington M.J., Kowarik M., Holt K.E., et al. The diversity of Klebsiella pneumoniae surface polysaccharides. Microb Genom. 2016;2(8):e000073. DOI: 10.1099/mgen.0.000073
55. Hsieh P.F., Lin T.L., Yang F.L., Wu M.C., Pan Y.J., Wu S.H., et al. Lipopolysaccharide O1 antigen contributes to the virulence in Klebsiella pneumoniae causing pyogenic liver abscess. PLoS One. 2012;7(3):e33155. DOI: 10.1371/journal.pone.0033155
56. Regue M., Izquierdo L., Fresno S., Pique N, Corsaro M.M., Naldi T., et al. A second outer-core region in Klebsiella pneumoniae lipopolysaccharide. J Bacteriol. 2005;187(12):4198-4206. DOI: 10.1128/JB.187.12.4198-4206.2005
57. Alexander C., Rietschel E.T. Bacterial lipopolysaccharides and innate immunity. J Endotoxin Res. 2001;7(3):167-202. PMID: 11581570
58. Adams P.G., Lamoureux L., Swingle K.L., Mukundan H., Montano G.A. Lipopolysaccharide-induced dynamic lipid membrane reorganization: tubules, perforations, and stacks. Biophys J. 2014;106(11):2395-2407. DOI: 10.1016/j.bpj.2014.04.016
59. Klein G., Lindner B., Brabetz W., Brade H., Raina S. Escherichia coli K-12 suppressor-free mutants lacking early glycosyltransferases and late acyltransferases: minimal lipopolysaccharide structure and induction of envelope stress response. J Biol Chem. 2009;284(23):15369-15389. DOI: 10.1074/jbc.M900490200
60. Mills G., Dumigan A., Kidd T., Hobley L., Bengoechea J.A. Identification and characterization of two Klebsiella pneumoniae lpxL Lipid A late acyltransferases and their role in virulence. Infect Immun. 2017;85(9):e00068-17. DOI: 10.1128/IAI.00068-17
61. Klein G., Raina S. Regulated assembly of LPS, its structural alterations and cellular response to LPS defects. Int J Mol Sci. 2019;20(2):356. DOI: 10.3390/ijms20020356
62. Cheng H.Y., Chen Y.F., Peng H.L. Molecular characterization of the PhoPQ-PmrD-PmrAB mediated pathway regulating polymyxin B resistance in Klebsiella pneumoniae CG43. J Biomed Sci. 2010;17(1):60. DOI: 10.1186/1423-0127-17-60
63. Llobet E., Campos M.A., Gimenez P., Moranta D., Bengoechea J.A. Analysis of the networks controlling the antimicrobial-peptidedependent induction of Klebsiella pneumoniae virulence factors. Infect Immun. 2011;79(9):3718-3732. DOI: 10.1128/IAI.05226-11
64. Gunn J.S. Bacterial modification of LPS and resistance to antimicrobial peptides. J Endotoxin Res. 2001;7(1):57-62. PMID: 11521084
65. Schrol C., Barken K.B., Krogfelt K.A., Struve C. Role of type 1 and type 3 fimbriae in Klebsiella pneumoniae biofilm formation. BMC Microbiol. 2010;10:179. DOI: 10.1186/1471-2180-10-179
66. Alcantar-Curiel M.D., Blackburn D., Saldana Z., GayossoVazquez C., Iovine N.M., De la Cruz M.A., et al. Multi-functional analysis of Klebsiella pneumoniae fimbrial types in adherence and biofilm formation. Virulence. 2013;4(2):129-138. DOI: 10.4161/viru.22974
67. Cubero M., Marti S., Dominguez M.A., Gonzalez-Diaz A., Berbel D., Ardanuy C. Hypervirulent Klebsiella pneumoniae serotype K1 clinical isolates form robust biofilms at the air-liquid interface. PLoS One. 2019;14(9):e0222628. DOI: 10.1371/journal.pone.0222628
68. Bryers J.D. Medical biofilms. Biotechnol Bioeng. 2008;100(1):118. DOI: 10.1002/bit.21838
69. Bandeira M., Borges V., Gomes J.P., Duarte A., Jordao L. Insights on Klebsiella pneumoniae biofilms assembled on different surfaces using phenotypic and genotypic approaches. Microorganisms. 2017;5(2):16. DOI: 10.3390/microorganisms5020016
70. Goncalves M.S., Delattre C., Balestrino D., Charbonnel N., Elboutachfaiti R., Wadouachi A., et al. Anti-biofilm activity: a function of Klebsiella pneumoniae capsular olysaccharide. PLoS One. 2014;9(6):e99995. DOI: 10.1371/journal.pone.0099995
71. Johnson J.G., Murphy C.N., Sippy J., Johnson T.J., Clegg S. Type 3 fimbriae and biofilm formation are regulated by the transcriptional regulators MrkHI in Klebsiella pneumoniae. J Bacteriol. 2011;193(14):3453-3460. DOI: 10.1128/JB.00286-11
72. Huertas M.G., Za´rate L., Acost I.C., Posada L., Cruz D.P., Lozano M., et al. Klebsiella pneumoniae yfiRNB operon affects biofilm formation, polysaccharide production and drug susceptibility. Microbiology. 2014;160:2595-2606. DOI: 10.1099/mic.0.081992-0
73. Cadavid E., Robledo S.M., Quinones W., Echeverri F. Induction of biofilm formation in Klebsiella pneumoniae ATCC 13884 by several drugs: the possible role of quorum sensing modulation. Antibiotics (Basel). 2018;7(4):103. DOI: 10.3390/antibiotics7040103
74. Bullen J.J., Rogers H.J., Griffiths E. Iron binding proteins and infection. Br J Haematol. 1972;23:389-392. DOI: 10.1111/j.1365-2141.1972.tb07073.x
75. Lin C.T., Wu C.C., Chen Y.S., Lai Y.C., Chi C., Lin J.C., et al. Fur regulation of the capsular polysaccharide biosynthesis and iron-acquisition systems in Klebsiella pneumoniae CG43. Microbiology. 2011;157(2):419-429. DOI: 10.1099/mic.0.044065-0
76. Palacios M., Broberg C.A., Walker K.A., Miller V.L. A serendipitous mutation reveals the severe virulence defect of a Klebsiella pneumoniae fepB mutant. mSphere. 2017;2(4):e00341-17. DOI: 10.1128/mSphere.00341-17
77. Bachman M.A., Oyler J.E., Burns S.H., Caza M., Lepine F, Dozois C.M., et al. Klebsiella pneumoniae yersiniabactin promotes respiratory tract infection through evasion of lipocalin 2. Infect Immun. 2011;79(8):3309-3316. DOI: 10.1128/IAI.05114-11
78. Hsieh P.F., Lin T.L., Lee C.Z., Tsai S.F., Wang J.T. Serum-induced iron-acquisition systems and TonB contribute to virulence in Klebsiella pneumoniae causing primary pyogenic liver abscess. J Infect Dis. 2008;197(12):1717-1727. DOI: 10.1086/588383
79. Bachman M.A., Lenio S., Schmidt L., Oyler J.E., Weiser J.N. Interaction of lipocalin 2, transferrin, and siderophores determines the replicative niche of Klebsiella pneumoniae during pneumonia. MBio. 2012;3(6). pii: e00224-11. DOI: 10.1128/mBio.00224-11
80. Chen Y.T., Chang H.Y., Lai Y.C., Pan C.C., Tsai S.F., Peng H.L. Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella pneumoniae CG43. Gene. 2004;337:189-198. DOI: 10.1016/j.gene.2004.05.008
81. Cuevas-Ramos G., Petit C.R., Marcq I., Boury M., Oswald E., Nougayrede J.P. Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells. Proc Natl Acad Sci U S A. 2010;107(25):11537-11542. DOI: 10.1073/pnas.1001261107
82. Nougayrede J.P., Homburg S., Taieb F., Boury M., Brzuszkiewicz E., Gottschalk G., et al. Escherichia coli induces DNA double-strand breaks in eukaryotic cells. Science. 2006;313(5788):848-851. DOI: 10.1126/science.1127059
83. Tronnet S., Garcie C., Brachmann A.O., Piel J., Oswald E., Martin P. High iron supply inhibits the synthesis of the genotoxin colibactin by pathogenic Escherichia coli through a non-canonical Fur/RyhB-mediated pathway. Pathog Dis. 2017;75(5). DOI: 10.1093/femspd/ftx066
84. Garcie C., Tronnet S., Garenaux A., McCarthy A.J., Brachmann A.O., Penary M., et al. The bacterial stress-responsive Hsp90 Chaperone (HtpG) is required for the production of the genotoxin colibactin and the siderophore yersiniabactin in Escherichia coli. J Infect Dis. 2016;214(6):916-924. DOI: 10.1093/infdis/jiw294
85. Chen Y.T., Lai Y.C., Tan M.C., Hsieh L.Y., Wang J.T., Shiau Y.R., et al. Prevalence and characteristics of pks genotoxin gene clusterpositive clinical Klebsiella pneumoniae isolates in Taiwan. Sci Rep. 2017;7:43120. DOI: 10.1038/srep43120
86. Tsai Y.K., Fung C.P., Lin J.C., Chen J.H., Chang F.Y., Chen T.L., et al. Klebsiella pneumoniae outer membrane porins OmpK35 and OmpK36 play roles in both antimicrobial resistance and virulence. Antimicrob Agents Chemother. 2011;55(4):14851493. DOI: 10.1128/AAC.01275-10
87. Wise M.G., Horvath E., Young K., Sahm D.F., Kazmierczak K.M. Global survey of Klebsiella pneumoniae major porins from ertapenem non-susceptible isolates lacking carbapenemases. J Med Microbiol. 2018;67(3):289-295. DOI: 10.1099/jmm.0.000691
88. Sukhorukova M.V., Edelstein M.V., Ivanchik N.V., Skleenova E.Yu., Shajdullina E.R., Azyzov I.S.; «MARATHON» study group. Antimicrobial resistance of nosocomial Enterobacterales isolates in Russia: results of multicenter epidemiological study “MARATHON 2015-2016”. Klinicheskaja mikrobiologija i antimikrobnaja himioterapija. 2019;21(2):147-159. Russian. (Сухорукова М.В., Эйдельштейн М.В., Иванчик Н.В., Склеенова Е.Ю., Шайдуллина Э.Р., Азизов И.С.; исследовательская группа «МАРАФОН». Антибиотикорезистентность нозокомиальных штаммов Enterobacterales в стационарах России: результаты многоцентрового эпидемиологического исследования «МАРАФОН 2015-2016». Клиническая микробиология и антимикробная химиотерапия. 2019;21(2):147159.) DOI: 10.36488/cmac.2019.2.147-159
89. Navon-Venezia S., Kondratyeva K., Carattoli A. Klebsiella pneumoniae: a major worldwide source and shuttle for antibiotic resistance. FEMS Microbiol Rev. 2017;41(3):252-275. DOI: 10.1093/femsre/fux013
90. Wendel A.F., Brodner A.H., Wydra S., Ressina S., Henrich B., Pfeffer K., et al. Genetic characterization and emergence of the metallo-β-lactamase GIM-1 in Pseudomonas spp. and Enterobacteriaceae during a long-term outbreak. Antimicrob Agents Chemother. 2013;57(10):5162-5165. DOI: 10.1128/AAC.00118-13
91. Lu Y., Zhao S., Liang H., Zhang W., Liu J., Hu H. The first report of a novel IncHI1B blaSIM-1-carrying megaplasmid pSIM-1-BJ01 from a clinical Klebsiella pneumoniae isolate. Infect Drug Resist. 2019;12:2103-2112. DOI: 10.2147/IDR.S212333
92. Liakopoulos A., Mevius D., Ceccarelli D. A review of SHV extended-spectrum β-lactamases: neglected yet ubiquitous. Front Microbiol. 2016;7:1374. DOI: 10.3389/fmicb.2016.01374
93. Bush K., Jacoby G.A., Medeiros A.A. A functional classification scheme for beta-lactamases and its correlation with molecular structure. Antimicrob Agents Chemother. 1995;39(6):12111233. DOI: 10.1128/aac.39.6.1211
94. Sirot D., Sirot J., Labia R., Morand A., Courvalin P., DarfeuilleMichaud A., et al. Transferable resistance to third-generation cephalosporins in clinical isolates of Klebsiella pneumoniae: identification of CTX-1, a novel β-lactamase. J Antimicrob Chemother. 1987;20(3):323-334. DOI: 10.1093/jac/20.3.323
95. Dubois V., Poirel L., Demarthe F., Arpin C., Coulange L., Minarini L.A., et al. Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant β-lactamase from Klebsiella pneumoniae. Antimicrob Agents Chemother. 2008;52(10):37923794. DOI: 10.1128/AAC.00387-08
96. Manageiro V., Ferreira E., Cougnoux A., Albuquerque L., Canica M., Bonnet R. Characterization of the inhibitor-resistant SHV β-lactamase SHV-107 in a clinical Klebsiella pneumoniae strain coproducing GES-7 enzyme. Antimicrob Agents Chemother. 2012;56(2):1042-1046. DOI: 10.1128/AAC.01444-10
97. Gutmann L., Ferre B., Goldstein F.W., Rizk N., Pinto-Schuster E., Acar J.F., et al. SHV-5, a novel SHV-type beta-lactamase that hydrolyzes broad-spectrum cephalosporins and monobactams. Antimicrob Agents Chemother. 1989;33:951-956. DOI: 10.1128/AAC.33.6.951
98. Nüesch-Inderbinen M.T., Kayser F.H., Hächler H. Survey and molecular genetics of SHV beta-lactamases in Enterobacteriaceae in Switzerland: two novel enzymes, SHV-11 and SHV-12. Antimicrob Agents Chemother. 1997;41(5):943-949. PMID: 9145849
99. Kliebe C., Nies B. A., Meyer J.F., Tolxdorff-Neutzling R.M., Wiedemann B. Evolution of plasmid-coded resistance to broadspectrum cephalosporins. Antimicrob Agents Chemother. 1985;28(2):302-307. DOI: 10.1128/aac.28.2.302
100. Podbielski A., Schönling J., Melzer B., Warnatz K., Leusch H.G. Molecular characterization of a new plasmid-encoded SHV-type β-lactamase (SHV-2 variant) conferring high-level cefotaxime resistance upon Klebsiella pneumoniae. J Gen Microbiol. 1991;137(3):569-578. DOI: 10.1099/00221287-137-3-569
101. Poirel L., Heritier C., Podglajen I., Sougakoff W., Gutmann L., Nordmann P. Emergence in Klebsiella pneumoniae оf a chromosome-encoded SHV b-Lactamase that compromises the efficacy of imipenem. Antimicrob Agents Chemother. 2003;47:755-758. DOI: 10.1128/AAC.47.2.755758.2003
102. Woodford N., Dallow J.W., Hill R.L., Palepou M.F., Pike R., Ward M.E., et al. Ertapenem resistance among Klebsiella and Enterobacter submitted in the UK to a reference laboratory. Int J Antimicrob Agents. 2007;29(4):456-459. DOI: 10.1016/j.ijantimicag.2006.11.020
103. Pulzova L., Navratilova L., Comor L. Alterations in outer membrane permeability favor drug-resistant phenotype of Klebsiella pneumoniae. Microbi Drug Resist. 2017;23(4):413-420. DOI: 10.1089/mdr.2016.0017
104. Chen F.J., Lauderdale T.L., Ho M., Lo H.J. The roles of mutations in gyrA, parC, and ompK35 in fluoroquinolone resistance in Klebsiella pneumoniae. Microb Drug Resist. 2003;9(3):265271. DOI: 10.1089/107662903322286472
105. Heidary M., Bahramian A., Hashemi A., Goudarzi M., Omrani V.F., Eslami G., et al. Detection of acrA, acrB, aac (6′)-Ib-cr, and qepA genes among clinical isolates of Escherichia coli and Klebsiella pneumoniae. Acta Microbiol Immunol Hung. 2017;64(1):63-69. DOI: 10.1556/030.63.2016.011
106. Wang M., Tran J.H., Jacoby G.A., Zhang Y., Wang F., Hooper D.C. Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai, China. Antimicrob Agents Chemother. 2003;47:2242-2248. DOI: 10.1128/aac.47.7.2242-2248.2003
107. Tran J.H., Jacoby G.A. Mechanism of plasmid-mediated quinolone resistance. Proc Natl Acad Sci U S A. 2002;99(8):5638-5642. DOI: 10.1073/pnas.082092899
108. Aathithan S., French G.L. Prevalence and role of efflux pump activity in ciprofloxacin resistance in clinical isolates of Klebsiella pneumoniae. Eur J Clin Microbiol Infect Dis. 2011;30(6):745752. DOI: 10.1007/s10096-010-1147-0
109. Rodriguez-Martinez J.M., Diaz de Alba P., Briales A., Machuca J., Lossa M., Fernandez-Cuenca F., et al. Contribution of OqxAB efflux pumps to quinolone resistance in extended-spectrumβ-lactamase-producing Klebsiella pneumoniae. J Antimicrob Chemother. 2013;68(1):68-73. DOI: 10.1093/jac/dks377
110. Garneau-Tsodikova S., Labby K.J. Mechanisms of resistance to aminoglycoside antibiotics: overview and perspectives. Medchemcomm. 2016;7(1):11-27. DOI: 10.1039/C5MD00344J
111. Xiaoliang W., Huiming H., Chunlei C., Beiwen Z. Genomic characterisation of a colistin-resistant Klebsiella pneumoniae ST11 strain co-producing KPC-2, FloR, CTX-M-55, SHV-12, FosA and RmtB causing a lethal infection. J Glob Antimicrob Resist. 2019;19:78-80. DOI: 10.1016/j.jgar.2019.08.023
112. Srinivasan V.B., Venkataramaiah M., Mondal A., Vaidyanathan V., Govil T., Rajamohan G. Functional characterization of a novel outer membrane porin KpnO, regulated by PhoBR two-component system in Klebsiella pneumoniae NTUH-K2044. PLoS One. 2012;7(7):e41505. DOI: 10.1371/journal.pone.0041505
113. Markley J.L., Wencewicz T.A. Tetracycline-inactivating enzymes. Front Microbiol. 2018;9:1058. DOI: 10.3389/fmicb.2018.01058
114. Villa L., Feudi C., Fortini D., Garcia-Fernandez A., Carattoli A. Genomics of KPC-producing Klebsiella pneumoniae sequence type 512 clone highlights the role of RamR and ribosomal S10 protein mutations in conferring tigecycline resistance. Antimicrob Agents Chemother. 2014;58(3):1707-1712. DOI: 10.1128/AAC.01803-13
115. Li L., Ye L., Zhang S., Meng H. Isolation and identification of aerobic bacteria carrying tetracycline and sulfonamide resistance genes obtained from a meat processing plant. J Food Sci. 2016;81(6):M1480-M1484. DOI: 10.1111/17503841.13318
116. Ruzin A., Visalli M.A., Keeney D., Bradford P. A. Influence of transcriptional activator RamA on expression of multidrug efflux pump AcrAB and tigecycline susceptibility in Klebsiella pneumoniae. Antimicrob Agents Chemother. 2005;49(3):10171022. DOI: 10.1128/AAC.49.3.1017-1022.2005
117. He F., Fu Y., Chen Q., Ruan Z., Hua X., Zhou H., et al. Tigecycline susceptibility and the role of efflux pumps in tigecycline resistance in KPC-producing Klebsiella pneumoniae. PLoS One. 2015;10(3):e0119064. DOI: 10.1371/journal.pone.0119064
118. Ogawa W., Onishi M., Ni R., Tsuchiya T., Kuroda T. Functional study of the novel multidrug efflux pump KexD from Klebsiella pneumoniae. Gene. 2012;498(2):177-182. DOI: 10.1016/j.gene.2012.02.008
119. Wang W., Guo Q., Xu X., Sheng Z.K., Ye X., Wang M. High-level tetracycline resistance mediated by efflux pumps Tet (A) and Tet (A)-1 with two start codons. J Med Microbiol. 2014;63(11):14541459. DOI: 10.1099/jmm.0.078063-0
120. Chiu S.K., Huang L.Y., Chen H., Tsai Y.K., Liou C.H., Lin J.C., et al. Roles of ramR and tet (A) mutations in conferring tigecycline resistance in carbapenem-resistant Klebsiella pneumoniae clinical isolates. Antimicrob Agents Chemother. 2017;61(8):e0039117. DOI: 10.1128/AAC.00391-17
121. Domenech-Sanchez A., Martinez-Martinez L., HernandezAlles S., del Carmen Conejo M., Pascual A., Tomas J.M., et al. Role of Klebsiella pneumoniae OmpK35 porin in antimicrobial resistance. Antimicrob Agents Chemother. 2003;47(10):33323335. DOI: 10.1128/aac.47.10.3332-3335.2003
122. Gaffney D.F., Foster T.J., Shaw W.V. Chloramphenicol acetyltransferases determined by R plasmids from Gramnegative bacteria. J Gen Microbiol. 1978;109:351-358. DOI: 10.1099/00221287-109-2-351
123. Vester B., Garrett R.A. The importance of highly conserved nucleotides in the binding region of chloramphenicol at the peptidyl transfer centre of Escherichia coli 23S ribosomal RNA. EMBO J. 1988;7(11):3577-3587. PMID: 3061800
124. Schwarz S., Kehrenberg C., Doublet B., Cloeckaert A. Molecular basis of bacterial resistance to chloramphenicol and florfenicol. FEMS Microbiol Rev. 2004;28(5):519-542. DOI: 10.1016/j.femsre.2004.04.001
125. Cloeckaert A., Baucheron S., Chaslus-Dancla E. Nonenzymatic chloramphenicol resistance mediated by IncC plasmid R55 is encoded by a floR gene variant. Antimicrob Agents Chemother. 2001;45(8):2381-2382. DOI: 10.1128/AAC.45.8.23812382.2001
126. Lu P.L., Hsieh Y.J., Lin J.E., Huang J.W., Yang T.Y., Lin L., et al. Characterisation of fosfomycin resistance mechanisms and molecular epidemiology in extended-spectrum β-lactamase-producing Klebsiella pneumoniae isolates. Int J Antimicrob Agents. 2016;48(5):564-568. DOI: 10.1016/j.ijantimicag.2016.08.013
127. Bernat B.A., Laughlin L.T., Armstrong R.N. Fosfomycin resistance protein (FosA) is a manganese metalloglutathione transferase related to glyoxalase I and the extradiol dioxygenases. Biochemistry. 1997;36:3050-3055. DOI: 10.1021/bi963172a
128. Ito R., Mustapha M., Tomich A.D., Callaghan J.D., McElheny C.L., Mettus R.T., et al. Widespread fosfomycin resistance in Gramnegative bacteria attributable to the chromosomal fosA gene. mBio. 2017;8(4):e00749-17. DOI: 10.1128/mBio.00749-17
129. Xu Q., Jiang J., Zhu Z., Xu T., Sheng Z. K., Ye M., et al. Efflux Pumps AcrAB and OqxAB contribute to nitrofurantoin resistance in an uropathogenic Klebsiella pneumoniae isolate. Int J Antimicrob Agents. 2019;54(2):223-227. DOI: 10.1016/j.ijantimicag.2019.06.004
130. Soge O.O., Adeniyi B.A., Roberts M.C. New antibiotic resistance genes associated with CTX-M plasmids from uropathogenic Nigerian Klebsiella pneumoniae. J Antimicrob Chemother. 2006;58(5):1048-1053. DOI: 10.1093/jac/dkl370
131. Tang Y., Shen P., Liang W., Jin J., Jiang X. A putative multireplicon plasmid co-harboring beta-lactamase genes blaKPC-2, blaCTX-M-14 and blaTEM-1 and trimethoprim resistance gene dfrA25 from a Klebsiella pneumoniae sequence type (ST) 11 strain in China. PLoS One. 2017;12(2):e0171339. DOI: 10.1371/journal.pone.0171339
132. Nishida S., Ono Y. Genomic analysis of a pan-resistant Klebsiella pneumoniae sequence type 11 identified in Japan in 2016. Int J Antimicrob Agents. 2019 Nov 23:105854. DOI: 10.1016/j.ijantimicag.2019.11.011
133. Liu Y.Y., Wang Y., Walsh T.R., Yi L.X., Zhang R., Spencer J., et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis. 2016;16(2):161168. DOI: 10.1016/S1473-3099(15)00424-7
134. Tchebotar I.V., Mayanskiy A.N., Mayanskiy N.A. Matrix of microbial biofilms. Klinicheskaja mikrobiologija i antimikrobnaja himioterapija. 2016;18(1):9-19. Russian. (Чеботарь И.В., Маянский А.Н., Маянский Н.А. Матрикс микробных биопленок. Клиническая микробиология и антимикробная химиотерапия. 2016;18(1):9-19.)
135. Anderl J.N., Franklin M.J., Stewart P.S. Role of antibiotic penetration limitation in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin. Antimicrob Agents Chemother. 2000;44(7):1818-1824. DOI: 10.1128/aac.44.7.18181824.2000
136. Singla S., Harjai K., Chhibber S. Susceptibility of different phases of biofilm of Klebsiella pneumoniae to three different antibiotics. J Antibiot. 2013;66(2):61-66. DOI: 10.1038/ja.2012.101
137. Carpenter J.L. Klebsiella pulmonary infections: occurrence at one medical center and review. Rev Infect Dis. 1990;12(4):672-682. DOI: 10.1093/clinids/12.4.672
138. Reid J.M., Barclay R.S., Stevenson J.G., Welsh T.M., McSwan N. Empyema due to Klebsiella pneumoniae. Thorax. 1967;22(2):170-175. DOI: 10.1136/thx.22.2.170
139. Yeh C.F., Li W.Y., Hsu Y.B. Klebsiella pneumoniae pharyngitis mimicking malignancy: a diagnostic dilemma. Infection. 2014;42(6):1047-1050. DOI: 10.1007/s15010-014-0643-z
140. Flores-Mireles A.L., Walker J.N., Caparon M., Hultgren S.J. Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nat Rev Microbiol. 2015;13(5):269284. DOI: 10.1038/nrmicro3432
141. Hyun M., Lee J.Y., Kim H.A., Ryu S.Y. Comparison of Escherichia coli and Klebsiella pneumoniae acute pyelonephritis in korean patients. Infect Chemother. 2019;51(2):130-141. DOI: 10.3947/ic.2019.51.2.130
142. Daikos G.L., Markogiannakis A., Souli M., Tzouvelekis L.S. Bloodstream infections caused by carbapenemase-producing Klebsiella pneumoniae: a clinical perspective. Expert Rev Anti Infect Ther. 2012;10(12):1393-1404. DOI: 10.1586/eri.12.138
143. Tumbarello M., Spanu T., Sanguinetti M., Citton R., Montuori E., Leone F., et al. Bloodstream infections caused by extendedspectrum-β-lactamase-producing Klebsiella pneumoniae: risk factors, molecular epidemiology, and clinical outcome. Antimicrob Agents Chemother. 2006;50(2):498-504. DOI: 10.1128/AAC.50.2.498-504.2006
144. Holland C.W. Friedlander’s bacillus meningitis. Can Med Assoc J. 1950;63(2):131-134.
145. Bakar B., Sungur C., Tekkok I.H. Bilateral chronic subdural hematoma contaminated with Klebsiella pneumoniae: an unusual case. J Korean Neurosurg Soc. 2009;45(6):397-400. DOI: 10.3340/jkns.2009.45.6.397
146. Liliang P.C., Lin Y.C., Su T.M., Rau C.S., Lu C.H., Chang W.N., et al. Klebsiella brain abscess in adults. Infection. 2001;29(2):8186. DOI: 10.1007/s15010-001-0069-2
147. Wang B., Zhang P., Li Y., Wang Y. Klebsiella pneumoniaeinduced multiple invasive abscesses: A case report and literature review. Medicine. 2019;98(39):e17362. DOI: 10.1097/MD.0000000000017362
148. Jun J.B. Klebsiella pneumoniae liver abscess. Infect Chemother. 2018;50(3):210-218. DOI: 10.3947/ic.2018.50.3.210
149. Tugal D., Lynch M., Hujer A.M., Rudin S., Perez F., Bonomo R.A. Multi-drug-resistant Klebsiella pneumoniae pancreatitis: a new challenge in a serious surgical infection. Surg Infect (Larchmt). 2015;16(2):188-193. DOI: 10.1089/sur.2012.175
150. Virgilio E., Castaldo P., Catta F., Tarantino G., Cavallini M. Abdominal surgical site infection due to Klebsiella pneumoniae carbapenemase-producing K. pneumoniae. Int Wound J. 2016;13(5):1075-1076. DOI: 10.1111/iwj.12528
151. Krapp F., Morris A.R., Ozer E.A., Hauser A.R. Virulence characteristics of carbapenem-resistant Klebsiella pneumoniae strains from patients with necrotizing skin and soft tissue infections. Sci Rep. 2017;7(1):13533. DOI: 10.1038/s41598017-13524-8
152. Tomczak H., Danczak-Pazdrowska A., Polanska A., OsmolaMankowska A., Pazdrowski J., Blazejewska-Gasior W., et al. Microbiological analysis of acute infections of the nail fold on the basis of bait thread test. Postepy Dermatol Alergol. 2017;34(2):110-115. DOI: 10.5114/ada.2017.67072
153. de Sanctis J., Teixeira L., van Duin D., Odio C., Hall G., Tomford J.W., et al. Complex prosthetic joint infections due to carbapenemase-producing Klebsiella pneumoniae: a unique challenge in the era of untreatable infections. Int J Infect Dis. 2014;25:73-78. DOI: 10.1016/j.ijid.2014.01.028
154. Ikeda Y., Shigemura K., Nomi M., Tabata C., Kitagawa K., Arakawa S., et al. Infection control following an outbreak of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated from catheter-associated urinary tract infection. Jpn J Infect Dis. 2018;71(2):158-161. DOI: 10.7883/yoken.JJID.2017.330
155. Foresti S., Di Bella S., Rovelli A., Sala A., Verna M., Bisi L., et al. Catheter-related bloodstream infection caused by KPC-producing Klebsiella pneumoniae in two pediatric hematological patients. Antimicrob Agents Chemother. 2015;59(12):7919-7920. DOI: 10.1128/AAC.01855-15
156. Yu W.L., Cheng C.C., Chuang Y.C. First report of acute purulent pericarditis by capsule genotype K1 Klebsiella pneumoniae in an alcoholic patient. Diagn Microbiol Infect Dis. 2009;63(3):346347. DOI: 10.1016/j.diagmicrobio.2008.12.003
157. Pai R.K., Wall T.S., Macgregor J.F., Abedin M., Freedman R.A. Klebsiella pneumoniae: a rare cause of device-associated endocarditis. Pacing Clin Electrophysiol. 2006;29(5):540-542. DOI: 10.1111/j.1540-8159.2006.00390.x
158. Yang T.H., Kuo S.T., Young Y.H. Necrotizing external otitis in a patient caused by Klebsiella pneumoniae. Eur Arch Otorhinolaryngol. 2006;263(4):344-346. DOI: 10.1007/s00405-005-0998-y
159. Ang L.P., Lee H.M., Au Eong K.G., Yap E.Y., Lim A.T. Endogenous Klebsiella endophthalmitis. Eye (Lond). 2000;14(6):855-860. DOI: 10.1038/eye.2000.236
160. Lin C.T., Tsai Y.Y. Klebsiella pneumoniae orbital cellulitis. Zhonghua Yi Xue Za Zhi (Taipei). 2001;64(9):551-554. PMID: 11768288
161. Walcher D.N. Klebsiella pneumoniae associated with infantile diarrhea. Am J Dis Child. 1949;78(1):61-64. DOI: 10.1001/archpedi.1949.02030050070004
162. Gregersen N., Van Nierop W., Von Gottberg A., Duse A., Davies V., Cooper P. Klebsiella pneumoniae with extended spectrum beta-lactamase activity associated with a necrotizing enterocolitis outbreak. Pediatr Infect Dis J. 1999;18(11):963967. DOI: 10.1097/00006454-199911000-00005
163. Gabida M., Gombe N.T., Chemhuru M., Takundwa L., Bangure D., Tshimanga M. Foodborne illness among factory workers, Gweru, Zimbabwe, 2012: a retrospective cohort study. BMC Res Notes. 2015;8:493. DOI: 10.1186/s13104-015-1512-2
164. Yu W.Y., Zhu K.J., Li Q.P., Lou C., He D.W. Successful medical drainage and surgical treatment for vertebral osteomyelitis and bilateral psoas abscess with gas formation caused by Klebsiella pneumoniae in a diabetic patient. Rev Assoc Med Bras. 2019;65(5):678-681. DOI: 10.1590/1806-9282.65.5.678
165. Dutt S. N., Kameswaran M. The aetiology and management of atrophic rhinitis. J Laryngol Otol. 2005;119(11):843-852. DOI: 10.1258/00222150577478337
166. Miller R.H., Shulman J.B., Canalis R.F., Ward P.H. Klebsiella rhinoscleromatis: a clinical and pathogenic enigma. Otolaryngol Head Neck Surg. 1979;87(2):212-221. DOI: 10.1177/019459987908700211
167. Kuo P.H., Huang K.H., Lee C.W., Lee W.J., Chen S.J., Liu K.L. Emphysematous prostatitis caused by Klebsiella pneumoniae. J Formos Med Assoc. 2007;106(1):74-77. DOI: 10.1016/S0929-6646(09)60219-9
168. Wakabayashi Y., Jubishi D., Okamoto K., Ikeda M., Tatsuno K., Mizoguchi M., et al. A rare case of a prostatic abscess, bacteremia and chronic granulomatous disease associated with Klebsiella pneumoniae. J Infect Chemother. 2019;25(5):365-367. DOI: 10.1016/j.jiac.2018.11.015
169. Tsai Y.J., Lin Y.C., Harnnd D.J., Chiang R.P., Wu H.M. A Lemierre syndrome variant caused by Klebsiella pneumoniae. J Formos Med Assoc. 2012;111(7):403-405. DOI: 10.1016/j.jfma.2012.03.012
170. Luo Y., Wang Y., Ye L., Yang J. Molecular epidemiology and virulence factors of pyogenic liver abscess causing Klebsiella pneumoniae in China. Clin Microbiol Infect. 2014;20(11):O818-O824. DOI: 10.1111/1469-0691
171. Brisse S., Fevre C., Passet V., Issenhuth-Jeanjean S., Tournebize R., Diancourt L., Grimont P. Virulent clones of Klebsiella pneumoniae: identification and evolutionary scenario based on genomic and phenotypic characterization. PloS One. 2009;4(3):e4982. DOI: 10.1371/journal.pone.0004982
172. Chebotar I.V., Ponomarenko O.A., Lazareva A.V., Karaseva O.V., Gorelik A.L., Bocharova YU.A., et al. MALDI-TOF technique availability for identification of septic agents in pediatric practice. Sovremennye tehnologii v medicine. 2015;7(2):68-74. Russian. (Чеботарь И.В., Пономаренко О.А., Лазарева А.В., Карасева О.В., Горелик А.Л., Бочарова Ю.А. и соавт. Использование MALDI-TOF-технологии для идентификации возбудителей септических состояний в педиатрической практике. Современные технологии в медицине. 2015;7(2):68-74.) DOI: 10.17691/stm2015.7.2.09
173. Brisse S., Verhoef J. Phylogenetic diversity of Klebsiella pneumoniae and Klebsiella oxytoca clinical isolates revealed by randomly amplified polymorphic DNA, gyrA and parC genes sequencing and automated ribotyping. Int J Syst Evol Microbiol. 2001;51:915-924. DOI: 10.1099/00207713-51-3-915
174. Maatallah M., Vading M., Kabir M.H., Bakhrouf A., Kalin M., Naucler P., et al. Klebsiella variicola is a frequent cause of bloodstream infection in the Stockholm area, and associated with higher mortality compared to K. pneumoniae. PLoS One. 2014;9:e113539. DOI: 10.1371/journal.pone.0113539
175. Berrazeg M., Diene S.M., Drissi M., Kempf M., Richet H., Landraud L., et al. Biotyping of multidrug-resistant Klebsiella pneumoniae clinical isolates from France and Algeria using MALDI-TOF MS. PloS One. 2013;8(4):e61428. DOI: 10.1371/journal.pone.0061428
176. Rodrigues C., Novais A., Sousa C., Ramos H., Coque T.M., Canton R., et al. Elucidating constraints for differentiation of major human Klebsiella pneumoniae clones using MALDI-TOF MS. Eur J Clin Microbiol Infect Dis. 2017;36(2):379-386. DOI: 10.1007/s10096-016-2812-8
177. Rodrigues C., Passet V., Rakotondrasoa A., Brisse, S. Identification of Klebsiella pneumoniae, Klebsiella quasipneumoniae, Klebsiella variicola and related phylogroups by MALDI-TOF mass spectrometry. Front Microbiol. 2018;9:3000. DOI: 10.3389/fmicb.2018.03000
178. Yanovich Yu.A., Rachina S.A., Sukhorukova M.V., Savochkina Yu.A., Vatsik M.V., Petrov A.A. Hospital-acquired pneumonia in adults: the structure of pathogens and new features of etiological diagnosis. Farmateka. 2019;26(5):39-46. Russian. (Янович Ю.А., Рачина С.А., Сухорукова М.В., Савочкина Ю.А., Вацик М.В., Петров А.А. Нозокомиальная пневмония у взрослых: структура возбудителей и новые возможности этиологической диагностики. Фарматека. 2019;26(5):39-46.) DOI: 10.18565/pharmateca.2019.539-46
179. Goering R.V. Pulsed field gel electrophoresis: a review of application and interpretation in the molecular epidemiology of infectious disease. Infect Genet Evol. 2010;10(7):866-875. DOI: 10.1016/j.meegid.2010.07.023.

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