Диагностика, терапия и профилактика внебольничного бактериального менингита: обзор практических рекомендаций Европейского общества по клинической микробиологии и инфекционным болезням и специализированных научных обществ Великобритании

Клиническая Микробиология и Антимикробная Химиотерапия. 2017; 19(2):102-115

​ Соловей Н.В., Карпов И.А., Давыдов А.В., Щерба В.В., Данилов Д.Е., Анисько Л.А., Решетник В.В., Рогачева Т.А., Жлобович И.Н.
внебольничные инфекции бактериальный менингит цереброспинальная жидкость антибактериальная терапия глюкокортикостероиды
Раздел
Болезни и возбудители
Тип
Журнальная статья
Публикация
Клиническая Микробиология и Антимикробная Химиотерапия. 2017; 19(2):102-115

Аннотация

Внебольничный бактериальный менингит является одним из наиболее тяжёлых инфекционных поражений центральной нервной системы, способных быстро привести к летальному исходу даже ранее здоровых пациентов при неадекватной тактике ведения. В статье приведён обзор современных принципов диагностики, терапии и профилактики внебольничного бактериального менингита, основанных на последних практических рекомендациях Европейского общества по клинической микробиологии и инфекционным болезням и специализированных научных обществ Великобритании, а также личном опыте авторов.

Соловей Н.В.

УО «Белорусский государственный медицинский университет», Минск, Республика Беларусь

Карпов Игорь Александрович

УО «Белорусский государственный медицинский университет», Минск, Республика Беларусь

Давыдов Александр Владимирович

УО «Белорусский государственный медицинский университет», Минск, Республика Беларусь

Щерба В.В.

УЗ «Городская инфекционная клиническая больница», Минск, Республика Беларусь

Данилов Д.Е.

УО «Белорусский государственный медицинский университет», Минск, Республика Беларусь

Анисько Л.А.

УО «Белорусский государственный медицинский университет», Минск, Республика Беларусь
УЗ «Городская инфекционная клиническая больница», Минск, Республика Беларусь

Решетник В.В.

УО «Белорусский государственный медицинский университет», Минск, Республика Беларусь

Рогачева Т.А.

УО «Белорусский государственный медицинский университет», Минск, Республика Беларусь
УЗ «Городская инфекционная клиническая больница», Минск, Республика Беларусь

Жлобович И.Н.

УО «Международный государственный экологический институт имени А.Д. Сахарова» БГУ, Минск, Республика Беларусь

  • 1. Viallon A., Botelho-Nevers E., Zeni F. Clinical decision rules for acute bacterial meningitis: current insights. Open access emergency medicine: OAEM. 2016;8:7-16.
  • 2. Wall E., Cartwright K., Scarborough M., et al. High Mortality amongst Adolescents and Adults with Bacterial Meningitis in Sub-Saharan Africa: An Analysis of 715 Cases from Malawi. PLoS One. 2013;8(7):e69783.
  • 3. Busl K., Bleck T. Bacterial infections of the central nervous system. Curr Infect Dis Rep. 2013;15(6):612-630.
  • 4. van de Beek D., Cabellos C., Dzupova O., et al. ESCMID guideline: diagnosis and treatment of acute bacterial meningitis. Clin Microbiol Infect. 2016;22(Suppl 3):S37-62.
  • 5. McGill F., Heyderman R., Michael B., et al. The UK joint specialist societies guideline on the diagnosis and management of acute meningitis and meningococcal sepsis in immunocompetent adults. J Infect. 2016;72(4):405- 438.
  • 6. Mace S. Acute bacterial meningitis. Emerg Med Clin North Am. 2008;26(2):281-317.
  • 7. Thigpen M., Whitney C., Messonnier N., et al. Bacterial meningitis in the United States, 1998-2007. N Engl J Med. 2011;364(21):2016-2025.
  • 8. van de Beek D., Brouwer M., Thwaites G., Tunkel A. Advances in treatment of bacterial meningitis. Lancet. 2012;380(9854):1693-1702.
  • 9. McIntyre P., O’Brien K., Greenwood B., van de Beek D. Effect of vaccines on bacterial meningitis worldwide. Lancet. 2012;380(9854):1703-1711.
  • 10. Schuchat A., Robinson K., Wenger J., et al. Bacterial meningitis in the United States in 1995. Active Surveillance Team. N Engl J Med. 1997;337(14):970- 976.
  • 11. Bijlsma M., Bekker V., Brouwer M., et al. Epidemiology of invasive meningococcal disease in the Netherlands, 1960-2012: an analysis of national surveillance data. Lancet Infect Dis. 2014;14(9):805-812.
  • 12. Koopmans M., Brouwer M., Bijlsma M., et al. Listeria monocytogenes sequence type 6 and increased rate of unfavorable outcome in meningitis: epidemiologic cohort study. Clin Infect Dis. 2013;57(2):247-253.
  • 13. Brouwer M., Tunkel A., van de Beek D. Epidemiology, diagnosis, and antimicrobial treatment of acute bacterial meningitis. Clin Microbiol Rev. 2010;23:467-492.
  • 14. Adriani K., Brouwer M., van der Ende A., van de Beek D. Bacterial meningitis in adults after splenectomy and hyposplenic states Mayo Clin Proc. 2013;88(6):571-578.
  • 15. Cabellos C., Viladrich P., Ariza J., et al. Community-acquired bacterial meningitis in cirrhotic patients. Clin Microbiol Infect. 2008;14(1):35-40.
  • 16. Domingo P., Suarez-Lozano I., Torres F., et al. Bacterial meningitis in HIV-1- infected patients in the era of highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2009;51(5):582-587.
  • 17. Brouwer M., de Gans J., Heckenberg S., et al. Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and metaanalysis. Lancet Infect Dis. 2009;9(1):31-44.
  • 18. Bodilsen J., Dalager-Pedersen M., Schønheyder H., Nielsen H. Dexamethasone treatment and prognostic factors in community-acquired bacterial meningitis: a Danish retrospective population-based cohort study. Scand J Infect Dis. 2014;46(6):418-425.
  • 19. van de Beek D., de Gans J., Spanjaard L., et al. Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med. 2004;351(18):1849-1859.
  • 20. Dauchy F., Gruson D., Chêne G., et al. Prognostic factors in adult communityacquired bacterial meningitis: a 4-year retrospective study. Eur J Clin Microbiol Infect Dis. 2007;26(10):743-746.
  • 21. Domingo P., Pomar V., Benito N., Coll P. The changing pattern of bacterial meningitis in adult patients at a large tertiary university hospital in Barcelona, Spain (1982-2010). J Infect. 2013;66(2):147-154.
  • 22. Sigurdardóttir B., Björnsson O., Jónsdóttir K., Erlendsdóttir H., Gudmundsson S. Acute bacterial meningitis in adults. A 20-year overview. Arch Intern Med. 1997;157(4):425-430.
  • 23. Brouwer M., Thwaites G., Tunkel A., van de Beek D. Dilemmas in the diagnosis of acute community-acquired bacterial meningitis. Lancet. 2012;380(9854):1684-1692.
  • 24. Hasbun R., Bijlsma M., Brouwer M., et al. Risk score for identifying adults with CSF pleocytosis and negative CSF Gram stain at low risk for an urgent treatable cause. J Infect. 2013;67(2):102-110.
  • 25. Østergaard C., Konradsen H., Samuelsson S. Clinical presentation and prognostic factors of Streptococcus pneumoniae meningitis according to the focus of infection. BMC Infect Dis. 2005;5:93.
  • 26. Heckenberg S., de Gans J. Brouwer M., et al. Clinical features, outcome, and meningococcal genotype in 258 adults with meningococcal meningitis: a prospective cohort study. Medicine (Baltimore). 2008;87(4):185-192.
  • 27. Georget-Bouquinet E., Bingen E., Aujard Y., et al. [Group B streptococcal meningitis’clinical, biological and evolutive features in children]. Arch Pediatr. 2008;15(Suppl 3):S126-132.
  • 28. Garges H., Moody M., Cotten C., et al. Neonatal meningitis: what is the correlation among cerebrospinal fluid cultures, blood cultures, and cerebrospinal fluid parameters? Pediatrics. 2006;117(4):1094-1100.
  • 29. Huy N., Thao N., Diep D., et al. Cerebrospinal fluid lactate concentration to distinguish bacterial from aseptic meningitis: a systemic review and metaanalysis. Crit Care. 2010;14(6):R240.
  • 30. Sakushima K., Hayashino Y., Kawaguchi T., Jackson J., Fukuhara S. Diagnostic accuracy of cerebrospinal fluid lactate for differentiating bacterial meningitis from aseptic meningitis: a meta-analysis. J Infect. 2011;62(4):255-262.
  • 31. Büttner T., Dorndorf W. [Viral encephalitis. Experiences with 53 patients in Middle Hessia]. Fortschr Neurol Psychiatr. 1988;56(10):315-325.
  • 32. Chow S., Rooney Z., Cleary M., Clayton P., Leonard J. The significance of elevated CSF lactate. Arch Dis Child. 2005;90(11):1188-1189.
  • 33. Nigrovic L., Malley R., Macias C., et al. Effect of antibiotic pretreatment on cerebrospinal fluid profiles of children with bacterial meningitis. Pediatrics. 2008;122(4):726-730.
  • 34. Dunbar S., Eason R., Musher D., Clarridge J. 3rd. Microscopic examination and broth culture of cerebrospinal fluid in diagnosis of meningitis. J Clin Microbiol. 1998;36(6):1617-1620.
  • 35. Bohr V., Rasmussen N., Hansen B., et al. 875 cases of bacterial meningitis: diagnostic procedures and the impact of preadmission antibiotic therapy. Part III of a three-part series. J Infect. 1983;7(3):193-202.
  • 36. Bryan J., de Silva H., Tavares A., Rocha H., Scheld W. Etiology and mortality of bacterial meningitis in northeastern Brazil. Rev Infect Dis. 1990;12(1):128- 135.
  • 37. Kanegaye J., Soliemanzadeh P., Bradley J. Lumbar puncture in pediatric bacterial meningitis: defining the time interval for recovery of cerebrospinal fluid pathogens after parenteral antibiotic pretreatment. Pediatrics. 2001;108(5):1169-1174.
  • 38. Kaplan S. Antigen detection in cerebrospinal fluid--pros and cons. Am J Med. 1983;75(1B):109-118.
  • 39. Nigrovic L., Kuppermann N., McAdam A., Malley R. Cerebrospinal latex agglutination fails to contribute to the microbiologic diagnosis of pretreated children with meningitis. Pediatr Infect Dis J. 2004;23(8):786-788.
  • 40. Tarafdar K., Rao S., Recco R., Zaman M. Lack of sensitivity of the latex agglutination test to detect bacterial antigen in the cerebrospinal fluid of patients with culture-negative meningitis. Clin Infect Dis. 2001;33(3):406- 408.
  • 41. Perkins M., Mirrett S., Reller L. Rapid bacterial antigen detection is not clinically useful. J Clin Microbiol. 1995;33(6):1486-1491.
  • 42. Saha S., Darmstadt G., Yamanaka N., et al. Rapid diagnosis of pneumococcal meningitis: implications for treatment and measuring disease burden. Pediatr Infect Dis J. 2005;24(12):1093-1098.
  • 43. Moïsi J., Saha S., Falade A., et al. Enhanced diagnosis of pneumococcal meningitis with use of the Binax NOW immunochromatographic test of Streptococcus pneumoniae antigen: a multisite study. Clin Infect Dis. 2009;48(Suppl 2):S49-56.
  • 44. Parent du Châtelet I., Traore Y., Gessner BD., et al. Bacterial meningitis in Burkina Faso: surveillance using field-based polymerase chain reaction testing. Clin Infect Dis. 2005;40(1):17-25.
  • 45. Heinsbroek E., Ladhani S., Gray S., et al. Added value of PCR-testing for confirmation of invasive meningococcal disease in England. J Infect. 2013;67(5):385-390.
  • 46. Munoz-Almagro C., Rodriguez-Plata M., Marin S., et al. Polymerase chain reaction for diagnosis and serogrouping of meningococcal disease in children. Diagn Microbiol Infect Dis. 2009;63(2):148-154.
  • 47. Sormunen P., Kallio M., Kilpi T., Peltola H. C-reactive protein is useful in distinguishing Gram stain-negative bacterial meningitis from viral meningitis in children. J Pediatr. 1999;134(6):725-729.
  • 48. Dubos F., Korczowski B., Aygun D., et al. Serum procalcitonin level and other biological markers to distinguish between bacterial and aseptic meningitis in children: a European multicenter case cohort study. Arch Pediatr Adolesc Med. 2008;162(12):1157-1163.
  • 49. Vikse J., Henry B., Roy J., et al. The role of serum procalcitonin in the diagnosis of bacterial meningitis in adults: a systematic review and metaanalysis. Int J Infect Dis. 2015;38:68-76.
  • 50. Wei T., Hu Z., Qin B., et al. Diagnostic Accuracy of Procalcitonin in Bacterial Meningitis Versus Nonbacterial Meningitis: A Systematic Review and MetaAnalysis. Medicine (Baltimore). 2016;95(11):e3079.
  • 51. Hasbun R., Abrahams J., Jekel J., Quagliarello V. Computed tomography of the head before lumbar puncture in adults with suspected meningitis. N Engl J Med. 2001;345(24):1727-1733.
  • 52. Aronin S., Peduzzi P., Quagliarello V. Community-acquired bacterial meningitis: risk stratification for adverse clinical outcome and effect of antibiotic timing. Ann Intern Med. 1998;129(11):862-869.
  • 53. Proulx N., Fréchette D., Toye B., Chan J., Kravcik S. Delays in the administration of antibiotics are associated with mortality from adult acute bacterial meningitis. QJM. 2005;98(4):291-298.
  • 54. Glimåker M., Johansson B., Grindborg Ö., et al. Adult bacterial meningitis: earlier treatment and improved outcome following guideline revision promoting prompt lumbar puncture. Clin Infect Dis. 2015;60(8):1162-1169.
  • 55. Kozlov R.S., Sivaja O.V., Krechikova O.I., Ivanchik N.V. Antimicrobial Resistance of Streptococcus pneumoniae in Russia over the 1999- 2009: Results of Multicenter Prospective Study PEHASus. Klinicheskaja mikrobiologija i antimikrobnaja himioterapija. 2010;12(4):329-341. Russian. (Козлов Р.С., Сивая О.В., Кречикова О.И., Иванчик Н.В. Динамика антибиотикорезистентности Streptococcus pneumoniae к антибиотикам в России за период 1999-2009 гг. (результаты многоцентрового проспективного исследования ПеГАС). Клиническая микробиология и антимикробная химиотерапия. 2010;12(4):329-341.).
  • 56. Vázquez J., Enriquez R., Abad R., et al. Antibiotic resistant meningococci in Europe: any need to act? FEMS Microbiol Rev. 2007;31(1):64-70.
  • 57. Fangio P., Desbouchages L., Lachérade J., et al. Neisseria meningitidis C:2b:P1.2,5 with decreased susceptibility to penicillin isolated from a patient with meningitis and purpura fulminans. Eur J Clin Microbiol Infect Dis. 2005;24(2):140-141.
  • 58. Wall R. Meningococcal disease - some issues in treatment. J Infect. 2001;42(2):87-99.
  • 59. Luaces Cubells C., García García J., Roca Martínez J., Latorre Otín C. Clinical data in children with meningococcal meningitis in a Spanish hospital. Acta Paediatr. 1997;86(1):26-29.
  • 60. Tunkel A., Hartman B., Kaplan S., et al. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis. 2004;39(9):1267- 1284.
  • 61. Karageorgopoulos D., Valkimadi P., Kapaskelis A., Rafailidis P., Falagas M. Short versus long duration of antibiotic therapy for bacterial meningitis: a meta-analysis of randomised controlled trials in children. Arch Dis Child. 2009;94(8):607-614.
  • 62. Pelkonen T., Roine I., Cruzeiro M., et al. Slow initial β-lactam infusion and oral paracetamol to treat childhood bacterial meningitis: a randomised, controlled trial. Lancet Infect Dis. 2011;11(8):613-621.
  • 63. Mook-Kanamori B., Geldhoff M., van der Poll T., van de Beek D. Pathogenesis and pathophysiology of pneumococcal meningitis. Clin Microbiol Rev. 2011;24(3):557-591.
  • 64. Brouwer M., McIntyre P., Prasad K., van de Beek D. Corticosteroids for acute bacterial meningitis. Cochrane Database Syst Rev. 2015;(9):CD004405.
  • 65. Mathur N., Garg A., Mishra T. Role of dexamethasone in neonatal meningitis: a randomized controlled trial. Indian J Pediatr. 2013;80(2):102-107.
  • 66. de Gans J., van de Beek D. and European Dexamethasone in Adulthood Bacterial Meningitis Study Investigators. Dexamethasone in adults with bacterial meningitis. N Engl J Med. 2002;347(20):1549-1556.
  • 67. Nguyen T., Tran T., Thwaites G., et al. Dexamethasone in Vietnamese adolescents and adults with bacterial meningitis. N Engl J Med. 2007;357(24):2431-2440.
  • 68. van de Beek D., Farrar J., de Gans J., et al. Adjunctive dexamethasone in bacterial meningitis: a meta-analysis of individual patient data. Lancet Neurol. 2010;9(3):254-263.
  • 69. Heckenberg S., Brouwer M., van der Ende A., van de Beek D. Adjunctive dexamethasone in adults with meningococcal meningitis. Neurology. 2012;79(15):1563-1569.
  • 70. Zalmanovici Trestioreanu A., Fraser A., Gafter-Gvili A., Paul M., Leibovici L. Antibiotics for preventing meningococcal infections. Cochrane Database Syst Rev. 2013;(10):CD004785.
  • 71. Adriani K., van de Beek D., Brouwer M., Spanjaard L., de Gans J. Community-acquired recurrent bacterial meningitis in adults. Clin Infect Dis. 2007;45(5):e46-51.
  • 72. Tebruegge M., Curtis N. Epidemiology, etiology, pathogenesis, and diagnosis of recurrent bacterial meningitis. Clin Microbiol Rev. 2008;21(3):519-537.
  • 73. Simmons R., Kirwan P., Beebeejaun K., et al. Risk of invasive meningococcal disease in children and adults with HIV in England: a population-based cohort study. BMC Med. 2015;13:297.
  • 74. Edmond K., Dieye Y., Griffiths U., et al. Prospective cohort study of disabling sequelae and quality of life in children with bacterial meningitis in urban Senegal. Pediatr Infect Dis J. 2010;29(11):1023-1029.
  • 75. Fortnum H., Davis A. Hearing impairment in children after bacterial meningitis: incidence and resource implications. Br J Audiol. 1993;27(1):43-52.
  • 76. Heckenberg S., Brouwer M., van der Ende A., Hensen E., van de Beek D. Hearing loss in adults surviving pneumococcal meningitis is associated with otitis and pneumococcal serotype. Clin Microbiol Infect. 2012;18(9):849-855.
  • 77. Worsøe L., Cayé-Thomasen P., Brandt C., Thomsen J., Østergaard C. Factors associated with the occurrence of hearing loss after pneumococcal meningitis. Clin Infect Dis. 2010;51(8):917-924.
  • 78. Hoogman M., van de Beek D., Weisfelt M., de Gans J., Schmand B. Cognitive outcome in adults after bacterial meningitis. J Neurol Neurosurg Psychiatry. 2007;78(10):1092-1096.
  • 79. Schmand B., de Bruin E., de Gans J., van de Beek D. Cognitive functioning and quality of life nine years after bacterial meningitis. J Infect. 2010;61(4):330-334.
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