Матрикс микробных биоплёнок | КМАХ

Матрикс микробных биоплёнок

Клиническая Микробиология и Антимикробная Химиотерапия. 2016; 18(1):9-19

​ Чеботарь И.В., Маянский А.Н., Маянский Н.А.
бактерии микроскопические грибы биоплёнки внеклеточный матрикс антибиоплёночная терапия
Раздел
Болезни и возбудители
Тип
Журнальная статья
Публикация
Клиническая Микробиология и Антимикробная Химиотерапия. 2016; 18(1):9-19

Аннотация

Обзор литературы посвящён обобщению информации, касающейся системообразующего атрибута микробных биоплёнок — внеклеточного матрикса. Проанализированы структурно-биохимические характеристики матрикса, формируемого актуальными видами патогенов. Детально описаны функции матрикса, включая его патогенетическую значимость в эволюции инфекционного процесса. Матрикс рассматривается в качестве индикатора биоплёночного процесса и имеет диагностическую ценность. В связи с этим в обзоре концентрируется внимание на методах обнаружения и изучения матрикса. Предложены фармацевтические и немедикаментозные пути контроля патогенетически значимых биоплёнок через дезорганизацию их матрикса. Обсуждается возможность использования матриксных структур в качестве компонентов вакцинных препаратов.

Чеботарь Игорь Викторович

ФГАУ «Научный центр здоровья детей», Москва, Россия

Маянский А.Н.

ГБОУ ВПО НижГМА Минздрава России, Нижний Новгород, Россия

Маянский Николай Андреевич

ФГАУ «Научный центр здоровья детей», Москва, Россия

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