Бронхиальная астма, ассоциированная с Chlamydophila pneumoniae-инфекцией

Клиническая Микробиология и Антимикробная Химиотерапия. 2007; 9(3):233-243

​ Белоцерковская Ю.Г., Казаков С.П., Синопальников А.И.
бронхиальная астма Chlamydophila pneumoniae макролиды азитромицин
Раздел
Болезни и возбудители
Тип
Журнальная статья
Публикация
Клиническая Микробиология и Антимикробная Химиотерапия. 2007; 9(3):233-243

Аннотация

В открытом рандомизированном сравнительном исследовании эффективности 8-недельной терапии азитромицином участвовал 71 пациент с нетяжёлой стабильной бронхиальной астмой. Диагностика хронической инфекции, вызванной Chlamydophila pneumoniae, осуществлялась серологическими методами. Затем пациенты распределялись в 4 группы: 2 лечебные (серопозитивная и серонегативная) и 2 группы контроля (серопозитивная и серонегативная). В определённые временные точки (до и после лечения; через 4 и 16 нед после окончания лечения) у пациентов оценивались дневные и ночные симптомы, ОФВ1, утренняя ПСВ и частота использования вентолина по требованию. По окончании лечения было выявлено достоверное улучшение ОФВ1 и ПСВ только в группе серопозитивных пациентов. В то же время не было выявлено достоверного изменения дневных и ночных симптомов и частоты приёма вентолина. По результатам исследования был сделан вывод о том, что лёгкое течение заболевания в меньшей степени ассоциируется с феноменом серопозитивности (IgA + IgG), нежели среднетяжёлое, а терапия азитромицином может быть эффективной только у пациентов с подтверждённой инфекцией.

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