Аннотация
Различные защитные системы человеческого организма препятствуют развитию вирусной инфекции. Долгое время была известна способность некоторых клеток блокировать репликацию ВИЧ, однако никому не удавалось объяснить наблюдаемый феномен. Недавно в клетках человека был обнаружен белок APOBEC3G, способный угнетать репликацию вируса путём прямого воздействия на синтезированную ДНК ВИЧ в инфицированных клетках. В свою очередь, в геноме ВИЧ может присутствовать ген vif (viral infectivity protein), экспрессия которого позволяет вирусу реплицироваться даже при наличии APOBEC3G. Обнаруженный белок APOBEC3G можно отнести к механизмам противовирусной защиты, которые составляют «внутриклеточный иммунитет», действующий параллельно с иммунной системой организма в целом.
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